Palmitic Acid Versus Stearic Acid: Effects of Interesterification and Intakes on Cardiometabolic Risk Markers—A Systematic Review

Rooijen, Merel A. van; Mensink, Ronald P.

doi:10.3390/nu12030615

Cited by 55 publications

(29 citation statements)

References 56 publications

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“…The role of interesterified fat on metabolism has been reported in previous studies [1] [10]. In a recent systematic review, the interesterification of palmitic or stearic acid-rich fats does not seem to affect fasting serum lipids and (apo) lipoproteins [13]. Other research suggests effects of the consumption of interesterified fat on lipoprotein metabolism, glycemic control, and serum liver enzymes [1] [14].…”

Section: Introductionmentioning

confidence: 74%

Effect of a Diet Rich in Interesterified, Non-Interesterified and Trans Fats on Biochemical Parameters and Oxidative Status of Balb-c Mice

Lima¹,

Castro²,

Grinevicius³

et al. 2020

FNS

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The aim of this study was to investigate the effects of different modified fats on the body weight, biochemical profile, and biomarkers of hepatic oxidative status in Balb-c mice. The animals were divided into four groups and fed for 75 days with a normolipidic (Control Group, CG) or hiperlipidic diets (40% kcal) containing a commercial interesterified fat (IFG) rich in palmitic acid (39%); a blend of non-interesterified fat (NIFG), with 2-fold less saturated fatty acids at the sn-2 position of triacylglycerols; or a partially hydrogenated vegetable oil (PHFG), source of trans fatty acid (20%) and of linolenic acid (6%). The mice of the IFG and NIFG presented similar results in all evaluated parameters. The serum biochemical profile and hepatic oxidative stress markers in mice of the PHFG were similar to CG, except for total cholesterol (TC) which was significantly higher (p < 0.05

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Section: Introductionmentioning

confidence: 74%

Effect of a Diet Rich in Interesterified, Non-Interesterified and Trans Fats on Biochemical Parameters and Oxidative Status of Balb-c Mice

Lima¹,

Castro²,

Grinevicius³

et al. 2020

FNS

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“…Important MUFAs are the palmitoleic (16:1) and oleic (18:1) acids [ 37 ]. It has been found that palmitic and stearic acids, as well as MUFAs, may reduce low-density lipoprotein (LDL) cholesterol, which is a well-known risk factor for coronary heart disease [ 38 , 39 ]. PUFAs include (i) essential FAs (EFAs), namely FAs that humans and other animals must ingest to maintain their body in healthy conditions even if cannot synthesize them, such as n-6 PUFAs/ω-6 FAs (e.g., linoleic and arachidonic acids), and (ii) n-3 PUFAs/ω-3 FAs (e.g., α-linolenic, eicosapentaenoic, and docosahexaenoic acids), based on the distance of the first double bond from the carbon belonging to the methyl end [ 37 ].…”

Section: Profiling Of Main Vegetable Oil Bioactive Compounds With mentioning

confidence: 99%

Nutraceutical Vegetable Oil Nanoformulations for Prevention and Management of Diseases

Vergallo

2020

Nanomaterials

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The scientific community is becoming increasingly interested in identifying, characterizing, and delivering nutraceuticals, which constitutes a multi-billion-dollar business. These bioactive agents are claimed to exhibit several health benefits, including the prevention and treatment of diseases such as arthritis, cancer, osteoporosis, cataracts, Alzheimer’s, and Huntington’s diseases, heart, brain and metabolic disorders, etc. Nutraceuticals are typically consumed as part of a regular human diet and are usually present within foods, comprising vegetable oil, although at low levels and variable composition. Thus, it is difficult to control the type, amount and frequency of their ingestion by individuals. Nanoformulations about vegetable oil-based bioactive compounds with nutraceutical properties are useful for overcoming these issues, while improving the uptake, absorption, and bioavailability in the body. The purpose of this current study is to review papers on such nanoformulations, particularly those relevant for health benefits and the prevention and management of diseases, as well as bioactives extracted from vegetable oils enhancing the drug effectiveness, retrieved through bibliographic databases by setting a timespan from January 2000 to April 2020 (about 1758 records).

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“…Hyperlipidemia clinical diagnosis requires fasting lipemia, but individuals are in the postprandial state for most of the 24 h. Therefore, fasting lipemia cannot comprehensively and accurately reflect lipid metabolism ( 1 , 2 ). The viewpoint that atherosclerosis (AS) is a postprandial phenomenon was proposed by Zilversmit as early as 1979 ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Atherosclerosis Induced by Postprandial Lipemia

Zhao

Liu

Yang

et al. 2021

Front. Cardiovasc. Med.

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Postprandial lipemia plays an important role in the formation, occurrence, and development of atherosclerosis, and it is closely related to coronary heart disease and other diseases involving endothelial dysfunction, oxidative stress, inflammation, and other mechanisms. Therefore, it has become a focus area for further research. The studies on postprandial lipemia mainly include TG, TRL, VLDL, CM, and remnant cholesterol. Diurnal triglyceride patterns and postprandial hyperlipidemia are very relevant and are now insufficiently covered. The possible mechanisms between postprandial lipemia and cardiovascular disease have been reviewed in this article by referring to relevant literature in recent years. The research progress on the effects of postprandial lipemia on endothelial function, oxidative stress, and inflammation is highlighted. The intervention of postprandial lipemia is discussed. Non-medicinal intervention such as diet and exercise improves postprandial lipemia. As medicinal intervention, statin, fibrate, ezetimibe, omega-3 fatty acids, and niacin have been found to improve postprandial lipid levels. Novel medications such as pemafibrate, PCSK9, and apoCIII inhibitors have been the focus of research in recent years. Gut microbiota is closely related to lipid metabolism, and some studies have indicated that intestinal microorganisms may affect lipid metabolism as environmental factors. Whether intervention of gut microbiota can reduce postprandial lipemia, and therefore against AS, may be worthy of further study.

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Palmitic Acid Versus Stearic Acid: Effects of Interesterification and Intakes on Cardiometabolic Risk Markers—A Systematic Review

Cited by 55 publications

References 56 publications

Effect of a Diet Rich in Interesterified, Non-Interesterified and Trans Fats on Biochemical Parameters and Oxidative Status of Balb-c Mice

Effect of a Diet Rich in Interesterified, Non-Interesterified and Trans Fats on Biochemical Parameters and Oxidative Status of Balb-c Mice

Nutraceutical Vegetable Oil Nanoformulations for Prevention and Management of Diseases

Mechanisms of Atherosclerosis Induced by Postprandial Lipemia

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