Palmoplantar pustulosis associated with gastric <i>Helicobacter pylori</i>
 infection

Helicobacter pylori (H. pylori) is the main cause of chronic gastritis and a major risk factor for gastric cancer. This pathogen has also been considered a potential trigger of gastric autoimmunity, and in particular of autoimmune gastritis. However, a considerable number of reports have attempted to link H. pylori infection with the development of extra-gastrointestinal autoimmune disorders, affecting organs not immediately relevant to the stomach. This review discusses the current evidence in support or against the role of H. pylori as a potential trigger of autoimmune rheumatic and skin diseases, as well as organ specific autoimmune diseases. We discuss epidemiological, serological, immunological and experimental evidence associating this pathogen with autoimmune diseases. Although over one hundred autoimmune diseases have been investigated in relation to H. pylori, we discuss a select number of papers with a larger literature base, and include Sjögrens syndrome, rheumatoid arthritis, systemic lupus erythematosus, vasculitides, autoimmune skin conditions, idiopathic thrombocytopenic purpura, autoimmune thyroid disease, multiple sclerosis, neuromyelitis optica and autoimmune liver diseases. Specific mention is given to those studies reporting an association of anti-H. pylori antibodies with the presence of autoimmune disease-specific clinical parameters, as well as those failing to find such associations. We also provide helpful hints for future research.

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“…To this end, several studies have investigated a possible link between H. pylori and psoriasis [67][68][69][70][71][72][73][74] .…”

Section: Psoriasismentioning

confidence: 99%

Helicobacter pyloriand autoimmune disease: Cause or bystander

Smyk¹,

Κουτσουμπασ²,

Mytilinaiou³

et al. 2014

WJG

153

108

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“…Due to the patient’s history of dyspepsia and due to a recent report associating Helicobacter pylori infection with PPP, 3 a 13 C‐urea breath test was performed and the presence of H. pylori infection was confirmed. Consequently, standard treatment for H. pylori eradication, consisting of amoxycillin (1 g twice daily) and clarythromycin (500 mg twice daily) for 7 days, in association with omeprazole (20 mg twice daily) was started.…”

mentioning

confidence: 99%

Complete remission of palmoplantar psoriasis through Helicobacter pylori eradication: a case report

Hübner¹,

Tenbaum²

2008

Clin Exp Dermatol

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“…74 Tonsillectomy and eradication of Helicobacter pylori. 61,75,76 lead to improvement of the dermatosis and osteo-articular symptoms, if present. 75,76,77 The mechanism involved in the stimulation of cutaneous lesions in chronic infections is unknown.…”

Section: Palmoplantar Pustulosismentioning

confidence: 99%

“…61,75,76 lead to improvement of the dermatosis and osteo-articular symptoms, if present. 75,76,77 The mechanism involved in the stimulation of cutaneous lesions in chronic infections is unknown. 75.77 Studies evaluate the participation of T lymphocytes (CD4 and CD28), antigens (cutaneous lymphocyteassociated antigen -CLA) and proteins (heat shock proteins) that would lead to the formation of cytokines (interleukin 6 and 8 , C5a, platelet activating factor, interferon gamma and tumor necrosis factor alpha), which would be responsible for the chemotaxis of neutrophils, pustule formation and development of skin lesions.…”

Section: Palmoplantar Pustulosismentioning

confidence: 99%

Dermatoses neutrofílicas: parte II

Razera

Olm

Bonamigo

2011

An. Bras. Dermatol.

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This article addresses neutrophilic dermatoses, thus complementing the previous article (part I). The following dermatoses are introduced and discussed: subcorneal pustular dermatosis (Sneddon-Wilkinson disease), dermatitis cruris pustulosa et atrophicans, acute generalized exanthematous pustulosis, continuous Hallopeau acrodermatitis, palmoplantar pustulosis, infantile acropustulosis, Andrews' pustular bacteride and eosinophilic pustular folliculitis. A brief review of neutrophilic dermatoses in pediatric patients is also conducted. Keywords: Neutrophil infiltration; Pediatrics; Skin diseases Resumo: Neste artigo são abordadas as dermatoses neutrofílicas, complementando o artigo anterior (parte I). São apresentadas e comentadas as seguintes dermatoses: pustulose subcórnea de SneddonWilkinson, dermatite crural pustulosa e atrófica, pustulose exantemática generalizada aguda, acrodermatite contínua de Hallopeau, pustulose palmoplantar, acropustulose infantil, bacteride pustular de Andrews e foliculite pustulosa eosinofílica. Uma breve revisão das dermatoses neutrofílicas em pacientes pediátricos também é realizada. Palavras-chave: Dermatopatias; Infiltração de neutrófilos; Pediatria

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Palmoplantar pustulosis associated with gastric Helicobacter pylori infection

Cited by 17 publications

References 4 publications

Helicobacter pyloriand autoimmune disease: Cause or bystander

Helicobacter pyloriand autoimmune disease: Cause or bystander

Complete remission of palmoplantar psoriasis through Helicobacter pylori eradication: a case report

Dermatoses neutrofílicas: parte II

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