Pan-Cancer Analysis of the Mitophagy-Related Protein PINK1 as a Biomarker for the Immunological and Prognostic Role

Zhu, Lizhe; Wu, Wei; Jiang, Siyuan; Yu, Shibo; Yu, Yan; Wang, Ke; He, Jing; Ren, Yu; Wang, Bin

doi:10.3389/fonc.2020.569887

Cited by 30 publications

(24 citation statements)

References 52 publications

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“…Increasing studies have described the value of pan-cancer analysis and have revealed the important roles of some driver genes in the development of cancer. 33,34 FTO, a m6A demethylase, has been identified to as a factor able to regulate the occurrence, progression, and prognosis of some cancers,…”

Section: Discussionmentioning

confidence: 99%

Pan-Cancer Analysis of the N6-Methyladenosine Eraser FTO as a Potential Prognostic and Immunological Biomarker

Zhao

Liu

et al. 2021

IJGM

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Section: Discussionmentioning

confidence: 99%

Pan-Cancer Analysis of the N6-Methyladenosine Eraser FTO as a Potential Prognostic and Immunological Biomarker

Zhao

Liu

et al. 2021

IJGM

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“…Recently, mitophagy-related genes (MRGs) such as PINK1, Parkin, FUNDC1, PHB2, and BNIP3 have developed as a potential target for the development of novel therapeutic strategies for overcoming cancer resistance [ 6 ]. In 2020, Zhu et al demonstrated that the abnormal expression of PINK1 can serve well as biomarker for prognosis of patients with HCC by pancancer analysis [ 7 ]. Yan et al identified another novel mitophagy pathway, PHB2-PARL-PGAM5-PINK1 axis, involved in cancer proliferation and progression, which may become a promising target for the anticancer agent [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Novel Mitophagy-Related Gene Prognostic Signature for Hepatocellular Carcinoma Based on Immunoscore Classification of Tumor

Chen

Wang

Zeng

et al. 2021

Journal of Oncology

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Emerging evidence suggested that mitophagy may play an important role in the progression of hepatocellular carcinoma (HCC), whereas the association between mitophagy-related genes and HCC patients’ prognosis remains unknown. In this study, we aimed to investigate the potential prognostic values of mitophagy-related genes (MRGs) on HCC patients at the genetic level. According to median immunoscore, we categorized HCC patients from TCGA cohort into two immune score groups, while 39 differential expression MRGs were identified. By using univariate analysis, we screened out 18 survival-associated MRGs, and then, the least absolute shrinkage and selection operator (LASSO) analysis was applied to construct a prognosis model that consisted of 9 MRGs (ATG7, ATG9A, BNIP3L, GABARAPL1, HTRA2, MAP1LC3B2, TFE3, TIGAR, and TOMM70). In our prognostic model, overall survival in the high and low-risk groups was significantly different P < 0.001 , and the respective areas under the curve (AUC) of our prognostic model were 0.686 for 3-year survival in the TCGA cohort and 0.776 for 3-year survival in the ICGC cohort. Moreover, we identified the risk score as the independent factor for predicting the HCC patients’ prognosis by using single and multifactor analyses, and a nomogram was also constructed for future clinical application. Further functional analyses showed that the immune status between two risk groups was significantly different. Our findings may provide a novel mitophagy-related gene signature, and these will be better used for prognostic prediction in HCC, thus improving patient outcome.

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“…However, the role of BRIP1 in the pathogenesis of various cancers remains to be illuminated. Pan-cancer studies have recently emerged as a novel perspective for understanding the molecular mechanisms of tumorigenesis and development of human cancers (29)(30)(31)(32)(33)(34)(35), and we failed to obtain the pan-cancer analysis of BRIP1 across human tumors from literature search. Therefore, we used the multilevel data of human databases to analyze the expression, prognostic potential, mutation, methylation, genomic characteristics, activation or inhabitation of cancer-related pathways, and immune in ltration of BRIP1 gene in 33 TCGA tumors, aimed to gure out the multimolecular characteristics and role of BRIP1 in the carcinogenesis, development, and prognosis of tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Our analyses showed that BRIP1 expression was associated with poor prognosis of PCPG, ACC, KICH, LGG, MESO, LIHC, KIRP, PAAD, UCEC, BRCA, OV, PRAD, and LUAD, and was also correlated to better prognosis of COAD, READ, STAD, and THYM. The survival data from various databases were not completely consistent, which might because of the heterogeneity of data collection in different databases (31). We then performed a COX regression analysis to explore the BRIP1 expression and several clinical characteristics in different cancers, and the results veri ed that BRIP1 acted as a risk factor in KIRP, ACC, LGG, MESO, and PAAD patients, and played a protective role in COAD, READ, STAD, and THYM patients.…”

Section: Discussionmentioning

confidence: 99%

Multimolecular Characteristics and Role of BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) in Human Tumors: A Pan-Cancer Analysis

Wang

Cui³

et al. 2022

Preprint

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Background The aberrant expression of BRIP1 was associated with several cancers, the panoramic picture of BRIP1 in human tumors is unclear. The purpose of this study is to explore the panoramic picture of expression of BRIP1 which was associated with several cancers. Methods Based on the data from TCGA, we utilized online databases to systematically analyze the multimolecular characteristics of BRIP1 in 33 human tumors. Results We observed prognosis-related differential BRIP1 expression between various carcinomas and the corresponding normal tissues. “Basal transcription factors”, “Homologous recombination”, “Nucleotide excision repair”, and DNA metabolism pathways may play a role in the functional mechanisms of BRIP1. Patients with uterine corpus endometrial carcinoma presented with the highest alteration frequency of BRIP1 (near 10%). Single nucleotide and copy number variation of BRIP1 were noticed in multiple cancer, and the expression of BRIP1 is significantly regulated by copy number variation in breast invasive carcinoma and lung squamous cell carcinoma. BRIP1 expression was negatively correlated to the methylation level in many human tumors, and the expression was associated with the activation of apoptosis, cell cycle, and DNA damage response, and inhibition of hormone ER and RNS/MARK signaling pathways. Moreover, a positive correlation was observed between BRIP1 expression and the immune infiltration level of cancer-associated fibroblasts and CD8 + T cells in lung adenocarcinoma. Conclusion Our pan-cancer analysis of BRIP1 provide valuable resource for understanding the characteristics of BRIP1 across human cancers.

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Pan-Cancer Analysis of the Mitophagy-Related Protein PINK1 as a Biomarker for the Immunological and Prognostic Role

Cited by 30 publications

References 52 publications

Pan-Cancer Analysis of the N6-Methyladenosine Eraser FTO as a Potential Prognostic and Immunological Biomarker

Pan-Cancer Analysis of the N6-Methyladenosine Eraser FTO as a Potential Prognostic and Immunological Biomarker

Development and Validation of a Novel Mitophagy-Related Gene Prognostic Signature for Hepatocellular Carcinoma Based on Immunoscore Classification of Tumor

Multimolecular Characteristics and Role of BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) in Human Tumors: A Pan-Cancer Analysis

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