Pan-Costochondritis Caused by Aspergillus Diagnosed by 18F-FDG PET/CT

Oliván-Sasot, P.; Martínez‐Sanchis, Begoña; Sánchez-Vañó, Raquel; Yepes-Agudelo, Ana María; Bello-Arqués, P.

doi:10.1097/rlu.0000000000002237

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Case reports have shown that patients who clinically presented with LC were eventually con rmed to have fungal infections such as Cryptococcal infection, invasive Aspergillus infection, or tuberculosis and granulomatous lesions [8][9][10][11][12][13][14] . Aside from malignant tumors, other benign lesions or certain infections can show increased glucose metabolism and present with similar manifestations.…”

Section: Discussionmentioning

confidence: 99%

Differential Diagnosis of Pulmonary Fungal Infection and Lung Cancer via 18F-FDG PET/CT: A Retrospective Study

Feng

Deng

et al. 2021

Preprint

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Background: There is limited evidence regarding the 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) characteristics of lung fungal (LF) infections with nodules or masses, which are often misdiagnosed as lung cancer (LC) with indications for surgery. We aimed to investigate the PET/CT findings of LF infections with nodules in comparison to those of LC and clarify the diagnostic value of 18F-FDG PET/CT in the differential diagnosis of LF infections.Methods: We enrolled 21 patients who presented with pulmonary nodules or masses on CT, were diagnosed with LF infections, and underwent PET/CT as the LF group and randomly selected 42 patients with LC diagnosed by pathology as the LC group. Clinical and PET/CT imaging data were statistically analyzed.Results: LC was the most common misdiagnosed disease in the LF group (52.38%). There were no significant differences in lung imaging features between the two groups. The levels of white blood cells, neutrophils, and IgG and the positive rates for fungal antigen test in the LF group were significantly higher than those in the LC group (P<0.05). Lung masses larger than 3 cm were more common in the LC group (P<0.05). Overall, 80.95% (17/21) of patients in the LF group showed increased 18F-FDG uptake. There were no significant between-group differences in the maximal standardized uptake value (SUVmax, 8.20 [2.70, 12.95] vs. 8.80 [7.00, 12.38]). In the LF group, eight, five, and eight patients had cryptococcal, Aspergillus, and Talaromyces marneffei infections, respectively, with no significant difference in SUVmax among them (5.10 [1.70, 14.40] vs. 8.20 [1.50, 8.20] vs. 8.50 [5.10, 11.30]). Conclusions: Both LF infection and LC can present with increased 18F-FDG uptake on PET/CT. Thus, it is difficult to distinguish between them according to lung PET/CT and CT manifestations. Patients presenting with pulmonary masses should also be suspected to have fungal infection, even those with an increased SUVmax and simultaneous lymph node and bone involvement; particular attention is needed for patients with abnormal inflammation indexes and fungal antigen test. We should be emphasized preoperative pathological examination and fungal etiology.

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Section: Discussionmentioning

confidence: 99%

Differential Diagnosis of Pulmonary Fungal Infection and Lung Cancer via 18F-FDG PET/CT: A Retrospective Study

Feng

Deng

et al. 2021

Preprint

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Heterogeneous imaging features of Aspergillosis at 18F-FDG PET/CT

Altini

Ruta

Mammucci

et al. 2022

Clin Transl Imaging

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Aspergillosis is one of the most frequent fungal infections, whose morbidity can be life-threatening, especially in some categories of patients such as immunocompromised ones. It can have various clinical presentation scenarios and should be considered when making differential diagnosis in patients with pulmonary and extrapulmonary involvement. 18F-FDG PET/CT is a whole-body diagnostic technique that can help in the study of the disease, guiding the patient management thanks to the possibility to recognize infection sites and extension. The aim of this manuscript is to provide an overview of the wide spectrum of disease presentation. Literature regarding 18F-FDG PET/CT in histologically confirmed aspergillosis cases has been revised to describe all its possible features, both usual and unusual to guide imaging interpretation. 18F-FDG PET/CT is a diagnostic tool that can help in the recognition of the heterogenous infection’s presentation, allowing the clinicians to make a prompt diagnosis and to have the most accurate management of the disease. Furthermore, other PET/CT radiopharmaceutical role in Aspergillosis imaging study have been presented.

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Costochondritis After Coronary Artery Bypass Grafting

Jamal

Sarwar

Fatima

et al. 2022

PJHS

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Costochondritis is painful inflammatory condition of costochondral junctions, which can be reproduced by palpating the affected joints. After CABG, musculoskeletal problems are major cause of chest pain due to median sternotomy. Prevalence of costochondritis in emergency department is 14% but its frequency in patients after coronary artery bypass grafting is not well established. Objective: To identify costochondritis as complication of sternotomy in post-operative CABG patients. Methods: This was a descriptive case series study in which 43 patients were included in study according to inclusion and exclusion criteria. 28 males and 15 females were included in the study with same baseline characteristics. Each patient was assessed using diagnostic criteria based on clinical history and physical examination, after 3 weeks of coronary artery bypass grafting, under supervision of cardiologist. Results: Mean age of patients was 51.14, with range minimum 30 years to maximum 70 years. 15 patients (34.9%) had costochondritis after CABG and 28 patients (65.1%) had other musculoskeletal causes of chest pain. Conclusions: Costochondritis after CABG is one major complication of sternotomy which causes severe chest pain, affecting 34.9% patients. It affects females twice as compare to males

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Pan-Costochondritis Caused by Aspergillus Diagnosed by 18F-FDG PET/CT

Cited by 3 publications

References 6 publications

Differential Diagnosis of Pulmonary Fungal Infection and Lung Cancer via 18F-FDG PET/CT: A Retrospective Study

Differential Diagnosis of Pulmonary Fungal Infection and Lung Cancer via 18F-FDG PET/CT: A Retrospective Study

Heterogeneous imaging features of Aspergillosis at 18F-FDG PET/CT

Costochondritis After Coronary Artery Bypass Grafting

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