Pan-Genome-Wide Association Study of Serotype 19A Pneumococci Identifies Disease-Associated Genes

Abstract

It is important to understand the genetic and pathogenic characteristics of S. pneumoniae serotype 19A, which may provide important information for the prevention and treatment of pneumococcal disease. This global large-sample pan-GWAS study has identified a subset of 30 consistently significant disease-associated genes that are involved in mobile genetic elements, antibiotic resistance, virulence, and cellular metabolism.

The impact of pneumococcal serotype replacement on the effectiveness of a national immunization program: a population-based active surveillance cohort study in New Zealand

“…This is important to note as ST-2062 is known to cause more illness among 19A carriers. 31 Further, our phylogenetic analysis shows that all sequenced NZ ST-2062 isolates were located within a ST-2062 lineage that is maybe associated with invasive disease ( Fig. 5 b); within this lineage, NZ isolates are in two subclades suggesting clonal expansion within NZ following two importation events.…”