Panax ginseng and salvia miltiorrhiza supplementation abolishes eccentric exercise-induced vascular stiffening: a double-blind randomized control trial

Lin, Hsin-Fu; Tung, Kang; Chou, Chien-Hsing; Lin, Ching-Che; Lin, Jaung‐Geng; Tanaka, Hirofumi

doi:10.1186/s12906-016-1139-4

Cited by 8 publications

(10 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study designs were variable and included 17 cross-over studies (Kingwell et al, 1997 ; Heffernan et al, 2007c , d ; Barnes et al, 2010 ; Collier et al, 2010 ; Yoon et al, 2010 ; Figueroa and Vicil, 2011 ; Ranadive et al, 2012 ; Ribeiro et al, 2014 ; Hanssen et al, 2015 ; Lefferts et al, 2015 ; Siasos et al, 2016a , b ; Thiebaud et al, 2016 ; Kobayashi et al, 2017 ; Yan et al, 2017 ; Tai et al, 2018 ), 24 pre-post interventions (Heffernan et al, 2006 , 2007a , b ; Lydakis et al, 2008 ; Munir et al, 2008 ; Peres et al, 2010 ; Boutcher et al, 2011 ; Doonan et al, 2011 , 2013 ; Hull et al, 2011 ; Hu et al, 2013 ; Lane et al, 2013 ; Gkaliagkousi et al, 2014 ; Yan et al, 2014 ; Burr et al, 2015 ; Chandrakumar et al, 2015 ; Mak and Lai, 2015 ; Milatz et al, 2015 ; Sugawara et al, 2015 ; Sun et al, 2015 ; Kingsley et al, 2016 ; Melo et al, 2016 ; Moore et al, 2016 ; Perdomo et al, 2016 ) and four randomized, controlled trials utilizing a pharmaceutical/placebo design (Sharman et al, 2008 ; Fahs et al, 2009 ; Campbell et al, 2011 ; Lin et al, 2016 ). Thirty-four studies assessed the effects of aerobic exercise (Table 2 ) and 13 examined the effects of resistance exercise (Table 3 ); two of these studies (Heffernan et al, 2007d ; Collier et al, 2010 ) compared the effects of aerobic vs. resistance exercise.…”

Section: Resultsmentioning

confidence: 99%

“…As no common post-intervention time point was assessed in all studies included in the review, data from the last time point within the immediate 60-min, post-intervention period were utilized for the meta-analysis. Three studies were excluded from the meta-analysis (Barnes et al, 2010 ; Lin et al, 2016 ; Perdomo et al, 2016 ) as they did not include data within the 60-min post-intervention period, while a fourth one (Collier et al, 2010 ) was excluded due to lack of pre-intervention data that could not be obtained from the corresponding author upon follow-up, leaving 41 studies to be included in the meta-analysis.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Acute Effects of Exercise Mode on Arterial Stiffness and Wave Reflection in Healthy Young Adults: A Systematic Review and Meta-Analysis

2018

View full text Add to dashboard Cite

Background: This systematic review and meta-analysis quantified the effect of acute exercise mode on arterial stiffness and wave reflection measures including carotid-femoral pulse wave velocity (cf-PWV), augmentation index (AIx), and heart rate corrected AIx (AIx75).Methods: Using standardized terms, database searches from inception until 2017 identified 45 studies. Eligible studies included acute aerobic and/or resistance exercise in healthy adults, pre- and post-intervention measurements or change values, and described their study design. Data from included studies were analyzed and reported in accordance with the Cochrane Handbook for Systematic Reviews of Interventions and PRISMA guidelines. Meta-analytical data were reported via forest plots using absolute differences with 95% confidence intervals with the random effects model accounting for between-study heterogeneity. Reporting bias was assessed via funnel plots and, individual studies were evaluated for bias using the Cochrane Collaboration's tool for assessing risk of bias. A modified PEDro Scale was applied to appraise methodological concerns inherent to included studies.Results: Acute aerobic exercise failed to change cf-PWV (mean difference: 0.00 ms−1 [95% confidence interval: −0.11, 0.11], p = 0.96), significantly reduced AIx (−4.54% [−7.05, −2.04], p = 0.0004) and significantly increased AIx75 (3.58% [0.56, 6.61], p = 0.02). Contrastingly, acute resistance exercise significantly increased cf-PWV (0.42 ms−1 [0.17, 0.66], p = 0.0008), did not change AIx (1.63% [−3.83, 7.09], p = 0.56), and significantly increased AIx75 (15.02% [8.71, 21.33], p < 0.00001). Significant heterogeneity was evident within all comparisons except cf-PWV following resistance exercise, and several methodological concerns including low applicability of exercise protocols and lack of control intervention were identified.Conclusions: Distinct arterial stiffness and wave reflection responses were identified following acute exercise with overall increases in both cf-PWV and AIx75 following resistance exercise potentially arising fromcardiovascular and non-cardiovascular factors that likely differ from those following aerobic exercise. Future studies should address identified methodological limitations to enhance interpretation and applicability of arterial stiffness and wave reflection indices to exercise and health.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Acute Effects of Exercise Mode on Arterial Stiffness and Wave Reflection in Healthy Young Adults: A Systematic Review and Meta-Analysis

2018

View full text Add to dashboard Cite

show abstract

“…A faster recovery of the joint range of motion and a lower increase in creatine kinase were obtained with supplementation after this eccentric-type exercise (31). Moreover, interleukin-6 increased with the placebo group, while it remained unchanged in the supplementation condition (31). Two other studies used animals performing a forced swimming test with chronic supplementation of Tanshinone IIA, a constituent from S. miltiorrhiza (32), or S. miltiorrhiza combined with Astragali (33).…”

Section: Discussionmentioning

confidence: 99%

“…In humans, fatigue has previously been considered in those complaining of chronic fatigue ( 23 ) with chronic supplementation of Salvia miltiorrhiza combined with Astragali . In healthy individuals, fatigue from exercise was explored with chronic supplementation in a single study performing a downhill running with S. miltiorrhiza combined with panax ginseng ( 31 ). A faster recovery of the joint range of motion and a lower increase in creatine kinase were obtained with supplementation after this eccentric-type exercise ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

“…In healthy individuals, fatigue from exercise was explored with chronic supplementation in a single study performing a downhill running with S. miltiorrhiza combined with panax ginseng ( 31 ). A faster recovery of the joint range of motion and a lower increase in creatine kinase were obtained with supplementation after this eccentric-type exercise ( 31 ). Moreover, interleukin-6 increased with the placebo group, while it remained unchanged in the supplementation condition ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acute Effects of Salvia Supplementation on Cognitive Function in Athletes During a Fatiguing Cycling Exercise: A Randomized Cross-Over, Placebo-Controlled, and Double-Blind Study

et al. 2021

View full text Add to dashboard Cite

Background:Salvia (sage) supplementation has been shown to improve the cognition function in healthy individuals or patients (e.g., attention, memory). To date, no study has explored its relevancy in the context of sporting performance. The aim of this study was to explore the acute effects of a combination of Salvia officinalis and Salvia lavandulaefolia on cognitive function in athletes performing a fatiguing cycling task.Methods: Twenty-six volunteers were included in this cross-over, randomized, double-bind vs. placebo trial. Two hours before the two experimental sessions (here called SAGE and PLACEBO), volunteers randomly received a supplementation of sage or placebo. During each experimental session, participants were tested at four occasions while cycling during a warm-up, in the middle and at the end of a fatiguing task and after a short 5-min recovery. Tests included a Stroop task, a simple reaction time task, and a backward digit span memory task. Heart rate and rating of perceived exertion (RPE) were also measured at the beginning of the four test sessions.Results: Heart rate was significantly greater during the fatiguing exercise than during warm-up and recovery (P < 0.001) without any supplementation effect. RPE was greater during the fatiguing exercise than during warm-up and recovery (P < 0.001). Moreover, RPE was significantly lower during the SAGE session as compared to PLACEBO (P = 0.002). Reaction time was not altered during the exercise but was significantly shorter with SAGE as compared to PLACEBO (P = 0.023). The Stroop task only revealed significantly longer reaction time during warm-up as compared to recovery (P = 0.02) independently of the supplementation. The digit span memory test revealed a significant greater span score with SAGE as compared to PLACEBO (P = 0.044).Conclusion: The combination of Salvia improved the cognitive functions (perceived exertion, working memory, and reaction time). The positive effects were obtained in fresh condition and were maintained with fatigue.

show abstract

Downhill Running: What Are The Effects and How Can We Adapt? A Narrative Review

et al. 2020

View full text Add to dashboard Cite

Downhill running (DR) is a whole-body exercise model that is used to investigate the physiological consequences of eccentric muscle actions and/or exercise-induced muscle damage (EIMD). In a sporting context, DR sections can be part of running disciplines (off-road and road running) and can accentuate EIMD, leading to a reduction in performance. The purpose of this narrative review is to: (1) better inform on the acute and delayed physiological effects of DR; (2) identify and discuss, using a comprehensive approach, the DR characteristics that affect the physiological responses to DR and their potential interactions; (3) provide the current state of evidence on preventive and in-situ strategies to better adapt to DR. Key findings of this review show that DR may have an impact on exercise performance by altering muscle structure and function due to EIMD. In the majority of studies, EIMD are assessed through isometric maximal voluntary contraction, blood creatine kinase and delayed onset muscle soreness, with DR characteristics (slope, exercise duration, and running speed) acting as the main influencing factors. In previous studies, the median (25th percentile, Q1; 75th percentile, Q3) slope, exercise duration, and running speed were − 12% (− 15%; − 10%), 40 min (30 min; 45 min) and 11.3 km h−1 (9.8 km h−1; 12.9 km h−1), respectively. Regardless of DR characteristics, people the least accustomed to DR generally experienced the most EIMD. There is growing evidence to suggest that preventive strategies that consist of prior exposure to DR are the most effective to better tolerate DR. The effectiveness of in-situ strategies such as lower limb compression garments and specific footwear remains to be confirmed. Our review finally highlights important discrepancies between studies in the assessment of EIMD, DR protocols and populations, which prevent drawing firm conclusions on factors that most influence the response to DR, and adaptive strategies to DR.

show abstract

Panax ginseng and salvia miltiorrhiza supplementation abolishes eccentric exercise-induced vascular stiffening: a double-blind randomized control trial

Cited by 8 publications

References 46 publications

Acute Effects of Exercise Mode on Arterial Stiffness and Wave Reflection in Healthy Young Adults: A Systematic Review and Meta-Analysis

Acute Effects of Exercise Mode on Arterial Stiffness and Wave Reflection in Healthy Young Adults: A Systematic Review and Meta-Analysis

Acute Effects of Salvia Supplementation on Cognitive Function in Athletes During a Fatiguing Cycling Exercise: A Randomized Cross-Over, Placebo-Controlled, and Double-Blind Study

Downhill Running: What Are The Effects and How Can We Adapt? A Narrative Review

Contact Info

Product

Resources

About