Panax notoginseng saponins ameliorates experimental hepatic fibrosis and hepatic stellate cell proliferation by inhibiting the Jak2/Stat3 pathways

Jiang, Hui; Gao, Jiarong; Wang, Yongzhong; Zhang, Jiafu; Han, Yanquan; Wei, Liangbing; Liu, Xiaochuang; Wu, Jingsong

doi:10.1016/s0254-6272(16)30030-9

Cited by 23 publications

(9 citation statements)

References 19 publications

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“…In Traditional Chinese Medicine (TCM), Panax has been employed to treat patients for a spectrum of liver diseases. According to Hui et al [148], Panax nontoginseng saponins (PNS) have been effective in the treatment of liver fibrosis. Likewise, PNS has been protective against triptolide [149] and ethanol [150]-induced liver damage.…”

Section: Liver Injury and Repairmentioning

confidence: 99%

Hormesis and Ginseng: Ginseng Mixtures and Individual Constituents Commonly Display Hormesis Dose Responses, Especially for Neuroprotective Effects

Calabrese

2020

Molecules

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This paper demonstrates that ginseng mixtures and individual ginseng chemical constituents commonly induce hormetic dose responses in numerous biological models for endpoints of biomedical and clinical relevance, typically providing a mechanistic framework. The principal focus of ginseng hormesis-related research has been directed toward enhancing neuroprotection against conditions such as Alzheimer’s and Parkinson’s Diseases, stroke damage, as well as enhancing spinal cord and peripheral neuronal damage repair and reducing pain. Ginseng was also shown to reduce symptoms of diabetes, prevent cardiovascular system damage, protect the kidney from toxicities due to immune suppressant drugs, and prevent corneal damage, amongst other examples. These findings complement similar hormetic-based chemoprotective reports for other widely used dietary-type supplements such as curcumin, ginkgo biloba, and green tea. These findings, which provide further support for the generality of the hormetic dose response in the biomedical literature, have potentially important public health and clinical implications.

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Section: Liver Injury and Repairmentioning

confidence: 99%

Hormesis and Ginseng: Ginseng Mixtures and Individual Constituents Commonly Display Hormesis Dose Responses, Especially for Neuroprotective Effects

Calabrese

2020

Molecules

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“…Regarding as the mechanism of suppressing HSC activation, we previously reported that the suppression of the toll-like receptor 4 (TLR4) and transforming growth factor β (TGF-β) showed one of the important mechanism related to the pharmacologic effect of TU-100 [29]. In other possibilities, Ginseng contained in TU-100 have reported that liver X receptors (LXRs), nuclear factor erythroid 2-related factor 2 (Nrf2) and janus kinase 2 (Jak2)/ signal transducer and activator of transcription 3 (Stat3) pathways are involved in HSC suppression [49,50]. Although, it is necessary to continue investigating the mechanism of TU-100 that suppresses HSC activation, this study showed that TU-100 decreased IL-6 secretion from HSCs and inhibited cell migration and proliferation through the suppressing of HSC activation.…”

Section: Discussionmentioning

confidence: 99%

The inhibitory effect of TU-100 on hepatic stellate cell activation in the tumor microenvironment

et al. 2020

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“…Moreover, PNS has been used in liver diseases. PNS ameliorates liver fibrosis in vivo and vitro [12]. Zhou’s study found that PNS protected liver against hepatotoxicity induced by Triptolide [13].…”

Section: Backgroudmentioning

confidence: 99%

Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice

Zhong

et al. 2019

BMC Complement Altern Med

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Backgroud The regenerative capacity of the liver is crucial for the host to survive after serious hepatic injuries, tumor resection, or living donor liver transplantation. Panax notoginseng saponins (PNS) have been reported to exert protective effects during organ injuries. The present study aimed to evaluate the effect of PNS on liver regeneration(LR) and on injuries induced by partial hepatectomy (PH). Methods We performed 70% partial PH on C57BL/6 J mice treated with or without PNS. LR was estimated by liver weight/body weight, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and cell proliferation, and the related cellular signals were analyzed by Western blot. Results Different concentrations of PNS promoted hepatocyte proliferation in vitro. Mice in the PNS group showed higher liver/body weight ratios at 2 d and 7 d ( P < 0.05) after PH and lower levels of serum ALT and AST ( P < 0.05) compared to those of mice in the normal control (NC) group. Histological analysis showed that the expression of proliferating cell nuclear antigen(PCNA) at 2 d and 7 d after PH was significantly higher in the PNS group than in the NC group ( P < 0.05). Mechanistically, the AKT/mTOR cell proliferation pathway and AKT/Bad cell survival pathway were activated by PNS, which accelerated hepatocyte proliferation and inhibited apoptosis ( P < 0.05). Conclusions PNS promoted liver regeneration through activation of PI3K/AKT/mTOR and upregulated the AKT/Bad cell pathways in mice.

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Panax notoginseng saponins ameliorates experimental hepatic fibrosis and hepatic stellate cell proliferation by inhibiting the Jak2/Stat3 pathways

Cited by 23 publications

References 19 publications

Hormesis and Ginseng: Ginseng Mixtures and Individual Constituents Commonly Display Hormesis Dose Responses, Especially for Neuroprotective Effects

Hormesis and Ginseng: Ginseng Mixtures and Individual Constituents Commonly Display Hormesis Dose Responses, Especially for Neuroprotective Effects

The inhibitory effect of TU-100 on hepatic stellate cell activation in the tumor microenvironment

Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice

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