Panayiotopoulos syndrome and benign partial epilepsy with centro-temporal spikes: A comparative incidence study

Weir, Elaine; Gibbs, J. M.; Appleton, Richard

doi:10.1016/j.seizure.2018.03.002

Cited by 17 publications

(17 citation statements)

References 14 publications

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“…A very recent investigation on the incidence of PS recorded over 16 months in a population aged below 16 years old, reported 0.8/100,000 new cases. Similar study also recorded 6.1/100,000 new cases of BECTS within the same population, reporting 13 times higher prevalence of BECTS than PS (Weir et al, 2018 ).…”

Section: Panayiotopoulos Syndromementioning

confidence: 64%

Sleep Related Epilepsy and Pharmacotherapy: An Insight

et al. 2018

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In the last several decades, sleep-related epilepsy has drawn considerable attention among epileptologists and neuroscientists in the interest of new paradigms of the disease etiology, pathogenesis and management. Sleep-related epilepsy is nocturnal seizures that manifest solely during the sleep state. Sleep comprises two distinct stages i.e., non-rapid eye movement (NREM) and rapid eye movement (REM) that alternate every 90 min with NREM preceding REM. Current findings indicate that the sleep-related epilepsy manifests predominantly during the synchronized stages of sleep; NREM over REM stage. Sleep related hypermotor epilepsy (SHE), benign partial epilepsy with centrotemporal spikes or benign rolandic epilepsy (BECTS), and Panayiotopoulos Syndrome (PS) are three of the most frequently implicated epilepsies occurring during the sleep state. Although some familial types are described, others are seemingly sporadic occurrences. In the present review, we aim to discuss the predominance of sleep-related epilepsy during NREM, established familial links to the pathogenesis of SHE, BECTS and PS, and highlight the present available pharmacotherapy options.

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Section: Panayiotopoulos Syndromementioning

confidence: 64%

Sleep Related Epilepsy and Pharmacotherapy: An Insight

et al. 2018

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“…En algunos casos se suelen resolver hasta entre los 11 y 13 años; no se reportan alteraciones significativas del desarrollo neurocognitivo. 1,5,10 Los reportes neuropsicológicos demuestran sutiles deficiencias en el lenguaje y el funcionamiento ejecutivo, así como afección de la memoria visual y problemas de lectura durante los periodos de crisis activas. 11,14 El estado epiléptico convulsivo motor es extremadamente raro; sin embargo, el estado epiléptico autonómico es muy común, consistiendo en crisis prolongadas con duración mayor de 30 minutos a un par de horas (aproximadamente dos horas) con pérdida de conciencia.…”

Section: Discussionunclassified

“…12,14 También se puede hacer diagnóstico diferencial de SP con epilepsia rolándica benigna, caracterizada por descargas EEG focales en las áreas centrales y centrotemporales, con edad de aparición máxima de tres a seis años, muy similar a SP. 5 Se ha reconocido ampliamente que las epilepsias focales idiopáticas de la infancia y las epilepsias generalizadas idiopáticas pueden coexistir, ya sea al mismo tiempo u ocurrir en diferentes periodos de edad en la misma persona. 6 Trastornos agudos no epilépticos como el síndrome de vómito cíclico, la gastroenteritis y reflujo gastroesofágico (ERGE) son otros de los diagnósticos a considerar debido a que los síntomas eméticos son las características clínicas predominantes al inicio de las convulsiones en SP.…”

Section: Discussionunclassified

Síndrome de Panayiotopoulos. Cuadro clínico y alteraciones electroencefalográficas

Berzabá¹,

García²,

Serna³

et al. 2021

Anales Médicos De La Asociación Médica Del Centro Médico ABC

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El síndrome de Panayiotopoulos es una epilepsia benigna de la infancia, diagnosticada comúnmente entre los tres y seis años, que se caracteriza por manifestaciones autonómicas, síntomas visuales y/o crisis motoras focales simples. La etiopatogenia aún no es clara. Se ha postulado la activación de áreas de bajo umbral de estructuras límbicas del cerebro interconectadas al sistema nervioso autónomo. Como hallazgos electroencefalográficos, se presentan puntas occipitales y extraoccipitales de gran amplitud. Las crisis son autolimitadas, con remisión espontánea uno o dos años después del inicio de la sintomatología. Objetivo: Describir las alteraciones clínicas y electroencefalográficas características en síndrome de Panayiotopoulos. Reporte de caso: Presentamos a un niño que inicia padecimiento a los 18 meses con convulsiones febriles tónico-clónicas generalizadas. A los cuatro años presenta palidez generalizada, náusea, vómito, seguido por versión cefálica y ocular a la izquierda, de tres a cinco minutos

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“…Evidence places OXC at Level A, while CBZ, PB, PHT, TPM, VPA, and VGB are Level C, and CLB, CZP, and LTG are potentially Level D, with respect to efficacy/effectiveness, as initial monotherapy in children with focal onset epilepsy that have been recently diagnosed or without previous therapy 27 .…”

Section: Question 8 What Drugs Should Be Used For Early Onset Occipital Epilepsy or Panayiotopoulos Syndrome?mentioning

confidence: 99%

Clinical guideline: antiepileptic drugs of choice for epileptic syndromes and epilepsies in pediatric patients

Reséndiz-Aparicio¹,

Padilla-Huicab²,

Martínez‐Juárez³

et al. 2021

RMN

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Approximately 65% of children with newly diagnosed epilepsy achieve sustained control of their epileptic seizures with the antiepileptic drug (AED) initially prescribed, and 15-20% require the combination of other AEDs. To begin treatment with an AED, basic aspects should be considered, such as the capacity for absorption, distribution, metabolism, and elimination of each AED. Treatment with an AED in pediatric patients, as for any age, must be personalized, but in these cases, the biological age and its degree of development are fundamental. Furthermore, the type of seizure, type of epileptic syndrome, comorbidity, in many cases the etiology, and even other aspects such as tolerability and availability of use must be considered. If adequate seizure control is not achieved, synergistic combinations could be used, making sure that adverse effects are not increased. Remember that a high percentage of patients initiate their epilepsy in the pediatric stage, which is why management in this age group is fundamental, and doses must always be calculated in relation to the weight of the patient.

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Panayiotopoulos syndrome and benign partial epilepsy with centro-temporal spikes: A comparative incidence study

Abstract: This study is the first to determine a comparative incidence of PS and BECTS. The findings suggest BECTS is eight times more common than PS and that the incidence of PS is lower than previously suggested.

Cited by 17 publications

References 14 publications

Sleep Related Epilepsy and Pharmacotherapy: An Insight

Sleep Related Epilepsy and Pharmacotherapy: An Insight

Síndrome de Panayiotopoulos. Cuadro clínico y alteraciones electroencefalográficas

Clinical guideline: antiepileptic drugs of choice for epileptic syndromes and epilepsies in pediatric patients

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