Pancancer analysis of SKA1 mutation and its association with the diagnosis and prognosis of human cancers

Lan, Hua; Yuan, Jing; Zhang, Rui; Jiang, Biyao; Li, Qiaofen; Huang, Zongyan; Chen, Peiling; Xiang, Huimin; Zeng, Xiangyang; Xiao, Songshu

doi:10.1016/j.ygeno.2022.110554

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…Another component, SKA1, a member of the kinetochore-associated protein complex, is also a protein involved in proper chromosome segregation (Hanisch et al 2006;Schmidt et al 2012). Pancancer analysis based on publicly available datasets has previously shown that SKA1 is overexpressed in multiple cancers and associated with poor prognosis (Lan et al, 2023). Moreover, in vitro studies have shown that downregulation of SKA1 through shRNA in adenosquamous carcinoma cell lines resulted in cell cycle arrest and apoptosis (Zhang et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Pan-Cancer TCGA Analysis Reveals the Potential Involvement of Lamin B2 in Dysregulating Chromosome Segregation in Human Cancer

Kundu,

Jit,

Sharma

2024

Preprint

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Lamins are fibrous proteins present just beneath the inner nuclear membrane and play a crucial role in shaping the genomic architecture. Several studies have reported the association of lamins with disease conditions such as cancer. Despite significant progress, the prognostic significance and underlying molecular targets of B-type lamins, especially lamin B2 in pan-cancer, have not been well studied. In this study, we have explored through bioinformatic analysis the potential functions of lamin B2 in driving cancer and its prognostic significance across pan-cancer TCGA datasets. Our results indicate the overexpression of lamin B2 in multiple human cancers, which is also correlated with poor overall and disease-free survival. Besides this, higher lamin B2 is associated with CD4+ Th1 and Th2 cell infiltration. We have identified 9 lamin B2 interacting proteins that are co-expressed with lamin B2 in cancerous conditions and, together with lamin B1, regulate cytokinesis and cell division pathways. Furthermore, we have identified specific molecular targets and independent functions of lamin B2 in dysregulating chromosome segregation and mRNA binding in multiple cancers. Our study, for the first time, has demonstrated the potential functions of lamin B2 and its prognostic significance across different cancers.

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Section: Discussionmentioning

confidence: 99%

Pan-Cancer TCGA Analysis Reveals the Potential Involvement of Lamin B2 in Dysregulating Chromosome Segregation in Human Cancer

Kundu,

Jit,

Sharma

2024

Preprint

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“…Many previous studies have demonstrated the important role of SKA1 in the malignant transformation and progression of multiple cancer types, because this gene can regulate various signaling pathways to affect tumor cell growth and metastasis [6] . Increasing clinical evidence has indicated that poor clinical prognosis, tumor invasion, and metastasis are all connected to increased SKA1 expression in a wide variety of cancers, including non-small cell lung cancer, bladder cancer, and hepatocellular carcinoma [ 7 – 9 ].…”

mentioning

confidence: 99%

Preliminary exploration of SKA1 expression in lung adenocarcinoma and its clinical significance

Zeng,

Chen,

Liu

et al. 2023

ABBS

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SKA1 promotes oncogenic properties in oral dysplasia and oral squamous cell carcinoma, and augments resistance to radiotherapy

Grandits,

Reinoehl,

Wagner

et al. 2024

Molecular Oncology

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Oral squamous cell carcinoma (OSCC) is a malignancy associated with high morbidity and mortality, yet treatment options are limited. In addition to genetic alterations, aberrant gene expression contributes to the pathology of malignant diseases. In the present study, we identified 629 genes consistently dysregulated between OSCC and normal oral mucosa across nine public gene expression datasets. Among them, mitosis‐related genes were significantly enriched, including spindle and kinetochore‐associated complex subunit 1 (SKA1), whose roles in OSCC had been studied only to a very limited extent. We show that SKA1 promoted proliferation and colony formation in 2D and 3D, shortened the duration of metaphase, and increased the migration of OSCC cell lines. In addition, high SKA1 expression enhanced radioresistance, a previously unknown effect of this gene, which was accompanied by a reduction of radiation‐induced senescence. SKA1 was also upregulated in a subset of advanced oral premalignancies and promoted tumor‐relevant properties in a corresponding cell line. Gene expression patterns evoked by SKA1 overexpression confirmed that this gene is able to advance properties required for both early and advanced stages of tumorigenesis. In summary, our data show that SKA1 contributes to malignant progression in OSCC and may be a useful marker of radioresistance in this disease.

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Pancancer analysis of SKA1 mutation and its association with the diagnosis and prognosis of human cancers

Cited by 5 publications

References 48 publications

Pan-Cancer TCGA Analysis Reveals the Potential Involvement of Lamin B2 in Dysregulating Chromosome Segregation in Human Cancer

Pan-Cancer TCGA Analysis Reveals the Potential Involvement of Lamin B2 in Dysregulating Chromosome Segregation in Human Cancer

Preliminary exploration of SKA1 expression in lung adenocarcinoma and its clinical significance

SKA1 promotes oncogenic properties in oral dysplasia and oral squamous cell carcinoma, and augments resistance to radiotherapy

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