Pancreas Development and Regeneration

Riley, Kimberly G.; Gannon, Maureen

doi:10.1016/b978-0-12-405945-0.00031-4

Principles of Developmental Genetics 2015

DOI: 10.1016/b978-0-12-405945-0.00031-4

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Pancreas Development and Regeneration

Kimberly G. Riley

Maureen Gannon

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2020

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Cited by 1 publication

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References 285 publications

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“…PTF1A and NGN3 repress the expression of each other 55 . Moreover, PDX1 56 , PTF1A 47 , NKX6.1 47 , SOX9 57 , and NGN3 58 are self-activated, which contribute to their sustaining expressions during pancreas development. The essential interactions of these TFs identified from genetic experiments are integrated and presented in Table 1.…”

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Adaptive Landscape Shaped by Core Endogenous Network Coordinates Complex Early Progenitor Fate Commitments in Embryonic Pancreas

Wang

Yuan

Zhu

et al. 2020

Sci Rep

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The classical development hierarchy of pancreatic cell fate commitments describes that multipotent progenitors (MPs) first bifurcate into tip cells and trunk cells, and then these cells give rise to acinar cells and endocrine/ductal cells separately. However, lineage tracings reveal that pancreatic progenitors are highly heterogeneous in tip and trunk domains in embryonic pancreas. The progenitor fate commitments from multipotency to unipotency during early pancreas development is insufficiently characterized. In pursuing a mechanistic understanding of the complexity in progenitor fate commitments, we construct a core endogenous network for pancreatic lineage decisions based on genetic regulations and quantified its intrinsic dynamic properties using dynamic modeling. The dynamics reveal a developmental landscape with high complexity that has not been clarified. Not only well-characterized pancreatic cells are reproduced, but also previously unrecognized progenitors—tip progenitor (TiP), trunk progenitor (TrP), later endocrine progenitor (LEP), and acinar progenitors (AciP/AciP2) are predicted. Further analyses show that TrP and LEP mediate endocrine lineage maturation, while TiP, AciP, AciP2 and TrP mediate acinar and ductal lineage maturation. The predicted cell fate commitments are validated by analyzing single-cell RNA sequencing (scRNA-seq) data. Significantly, this is the first time that a redefined hierarchy with detailed early pancreatic progenitor fate commitment is obtained.

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mentioning

confidence: 99%

Adaptive Landscape Shaped by Core Endogenous Network Coordinates Complex Early Progenitor Fate Commitments in Embryonic Pancreas

Wang

Yuan

Zhu

et al. 2020

Sci Rep

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scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Pancreas Development and Regeneration

Cited by 1 publication

References 285 publications

Adaptive Landscape Shaped by Core Endogenous Network Coordinates Complex Early Progenitor Fate Commitments in Embryonic Pancreas

Adaptive Landscape Shaped by Core Endogenous Network Coordinates Complex Early Progenitor Fate Commitments in Embryonic Pancreas

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