Pancreatic Acinar Cell Carcinoma: A Multi-institutional Study

Abstract

Acinar cell carcinoma of the pancreas is rare and appears to have a presentation and outcome distinct from the more common pancreatic DCA. Based upon these data, the outcome of patients with ACC is superior to that of DCA.

Acinar Cell Carcinoma of the Pancreas: A Literature Review and Update

“…Wisnoski et al [22] 672 (2008) ACC is a more indolent disease than PA. The long-term survival for patients with ACC is significantly better when compared to the long-term survival of patients with PA. Matos et al [23] 17 (2009) Acinar cell carcinoma of the pancreas is rare and appears to have a presentation and outcome distinct from the more common pancreatic DCA Lee et al [24] 29 (2010) In Korea, the clinical features of ACC include young age, large size, tail location and non-specific tumour markers. Surgery should be actively performed in the treatment of ACC regardless of size Hartwig et al [25] 17 (2011) ACC of the pancreas is a relatively rare tumour entity for which resection may result in long-term survival even in limited metastatic disease Butturini et al [26] 9 (2011) ACC represents a rare solid tumour of the pancreas.…”

Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review

“…A similar approach has been used by Matos et al [19]: neoadjuvant chemotherapy allowed surgical resection in one patient initially found at laparotomy with locally advanced tumor. The authors reported an excellent median survival (61 months) for patients treated with resection, however, these results should be interpreted with caution, as median follow-up was only 16 months.…”

“…Few case reports of ACCs (Table 3) also underline the uncertain clinical strategies for this disease which, however, seem to benefit from multi-drug chemotherapy or nonstandardized pancreatic cancer treatment approaches such as the intraperitoneal chemotherapy [21][22][23]. Matos et al interestingly report the longest term survival (67 months) of a patient treated without surgical procedure [19]. In the context of paucity information on ACCs, case reports as well as singular patient's history from small series stimulate the search for effective therapy even by nonconventional approach: however, primarily, we have to be cautious with pathology diagnosis arising from nonsurgical specimen.…”

Acinar Cell Carcinoma of the Pancreas in the United States: Prognostic Factors and Comparison to Ductal Adenocarcinoma

“…[1][2][3][4][5][6][7] More recently, multi-institutional series and the Pancreatic Cancer Registry of the Japan Pancreas Society (n=115) have also been examined. 8,9 Still, the number of patients examined is small; thus, conclusions are limited.…”