Pancreatic cancer: Lack of association between apparent diffusion coefficient values and adverse pathological features

Rosenkrantz, Andrew B.; Matza, Brent W.; Sabach, Amy; Hajdu, Christina H.; Hindman, Nicole

doi:10.1016/j.crad.2012.11.006

Cited by 45 publications

(42 citation statements)

References 30 publications

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“…10,12,14,16 In contrast, other studies have found no significant association between the ADC and histopathological subtypes in pancreatic cancers and meningiomas. 11,13 To the authors' knowledge, however, no studies have investigated the usefulness of DW imaging in the characterisation of bone metastasis.…”

Section: Discussionmentioning

confidence: 97%

Clinical relevance of the apparent diffusion coefficient value of metastatic bone tumours on diffusion-weighted MRI images: differences according to the types of primary tumour, the affected bones, and clinical factors

Jae

Yoon

2015

Clinical Radiology

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Section: Discussionmentioning

confidence: 97%

Clinical relevance of the apparent diffusion coefficient value of metastatic bone tumours on diffusion-weighted MRI images: differences according to the types of primary tumour, the affected bones, and clinical factors

Jae

Yoon

2015

Clinical Radiology

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“…40 This heterogeneity in histologic content is probably the cause of contradictory data in the relationship between ADC values of PA and tumor grade. 41,42 Moreover, the association of acute pancreatitis and PA located in the pancreatic head has been reported. Both entities show a similar behavior in DWI, hampering cancer detection.…”

Section: Diffusion-weighted Mr Imagingmentioning

confidence: 99%

Multiparametric MR Imaging in Abdominal Malignancies

Luna

Pahwa

Bonini³

et al. 2016

Magnetic Resonance Imaging Clinics of North America

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“…Legrand et al [44] reported that mean ADC values did not significantly differ between tumors having < 50% and those having > 50% of fibrotic stroma, or between tumors containing dense fibrosis and those containing loose fibrosis. Similarly, Rosenkrantz et al [45] reported no associations between ADC values and "adverse" pathological features as poor differentiation. Some authors have proposed a more practical role for functional imaging, testing correlations with clinical features as tumor stage or survival.…”

Section: Pancreatic Tumorsmentioning

confidence: 99%

“…Details on the most relevant published studies are reported in Table 2. Overall, low-grade PDACs tend to present low ADC values [43][44][45] , but it still not clear which histological feature mainly contributes to diffusion restriction. Wang et al [43] and Muraoka et al [46] reported that tumors with limited glandular formation and dense fibrosis (i.e., paucicellular tumors) had lower ADC values as compared to welldifferentiated lesions characterized by neoplastic tubular structures; moreover, PDACs with dense fibrosis showed significantly lower ADC values than those with loose fibrosis.…”

Section: Pancreatic Tumorsmentioning

confidence: 99%

“…Surgical resection is the only curative treatment for this neoplasm, therefore the preoperative prediction of the pathological grade may have a smaller importance for PDAC management as compared to other pancreatic tumors. Some studies have tried to correlate DWI findings with the pathological grade, but results are controversial [43][44][45] . Details on the most relevant published studies are reported in Table 2.…”

Section: Pancreatic Tumorsmentioning

confidence: 99%

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Prognostication and response assessment in liver and pancreatic tumors: The new imaging

Robertis¹,

Martini²,

Demozzi³

et al. 2015

WJG

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Diffusion-weighted imaging (DWI), dynamic contrastenhanced magnetic resonance imaging (DCE-MRI) and perfusion computed tomography (CT) are technical improvements of morphologic imaging that can evaluate functional properties of hepato-bilio-pancreatic tumors during conventional MRI or CT examinations. Nevertheless, the term "functional imaging" is commonly used to describe molecular imaging techniques, as positron emission tomography (PET) CT/MRI, which still represent the most widely used methods for the evaluation of functional properties of solid neoplasms; unlike PET or single photon emission computed tomography, functional imaging techniques applied to conventional MRI/CT examinations do not require the administration of radiolabeled drugs or specific equipments. Moreover, DWI and DCE-MRI can be performed during the same session, thus providing a comprehensive "one-step" morphological and functional evaluation of hepato-bilio-pancreatic tumors. Literature data reveal that functional imaging techniques could be proposed for the evaluation of these tumors before treatment, given that they may improve staging and predict prognosis or clinical outcome. Microscopic changes within neoplastic tissues induced by treatments can be detected and quantified with functional imaging, therefore these techniques could be used also for posttreatment assessment, even at an early stage. or altered cellular membranes will present diffusion restriction, which is depicted as signal hyperintensity areas on high b-value DW images and hypointensity on the apparent diffusion coefficient (ADC) maps; ADC measurement can also quantify water molecules' diffusion. As dedifferentiation or therapies may induce microscopic changes in neoplastic tissues that could modify water molecules' diffusion, DWI can distinguish between different degrees of malignancy and can be also proposed for post-treatment monitoring. Moreover, DWI can be performed in a single session with DCE-MRI, thus providing a comprehensive "one-step" morphological and functional evaluation of hepatobilio-pancreatic tumors.Perfusion imaging techniques evaluate changes in signal intensity (DCE-MRI) or density (pCT) after contrast medium injection, being therefore able to assess microvascularization through the evaluation of the dynamics of contrast medium distribution from vessels to the neoplastic tissue. Perfusion parameters are therefore theoretically good candidates for the evaluation of microscopic vascular differences between lesions with different pathological grade and for the assessment of treatment response, especially after chemoembolization or during treatments with antiangiogenic drugs.This editorial analyzes up-to-date literature data regarding the application of functional imaging techniques, apart from molecular imaging, to hepatic and pancreatic tumors, with particular emphasis on correlations to pathological features, prognostic stratification and therapeutic response assessment. FUNCTIONAL IMAGING TECHNIQUES: TECHNICAL BASESIn 1965 Stejskal and Tanne...

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Pancreatic cancer: Lack of association between apparent diffusion coefficient values and adverse pathological features

Cited by 45 publications

References 30 publications

Clinical relevance of the apparent diffusion coefficient value of metastatic bone tumours on diffusion-weighted MRI images: differences according to the types of primary tumour, the affected bones, and clinical factors

Clinical relevance of the apparent diffusion coefficient value of metastatic bone tumours on diffusion-weighted MRI images: differences according to the types of primary tumour, the affected bones, and clinical factors

Multiparametric MR Imaging in Abdominal Malignancies

Prognostication and response assessment in liver and pancreatic tumors: The new imaging

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