Pancreatic cancer with ovarian metastases: A case report and review of the literature

Wang, Shunda; Zhu, Liang; Wu, Huanwen; Dai, Menghua; Zhao, Yupei

doi:10.12998/wjcc.v8.i21.5380

Cited by 10 publications

(18 citation statements)

References 35 publications

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“…It has been reported that it is difficult to differentiate mucinous ovarian cancer from metastatic ovarian cancer pathologically [6]. However, the ultrasound findings of Krukenberg tumors are characterized by a smooth tumor surface with cystic components inside, which is different from primary ovarian cancer with solid components and papillary projections inside the tumor [1]. In the present case, the ultrasound findings showed a smooth surface tumor with cystic components typical of a Krukenberg tumor.…”

Section: Discussionmentioning

confidence: 45%

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A Case of Ovarian Metastasis of Pancreatic Cancer Causing Ovarian Torsion

Tanabe¹,

Sugino²,

Ichida³

et al. 2022

Cureus

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A 55-year-old female who had been diagnosed with stage 4 pancreatic cancer visited the emergency department of our hospital owing to sudden lower abdominal pain and was found to have an ovarian tumor. An urgent laparoscopic resection of the right adnexa was performed with a diagnosis of ovarian tumor stalk torsion. Postoperative pathological diagnosis revealed ovarian metastasis of pancreatic cancer. Our case report demonstrates that an ovarian tumor on one side in a patient with advanced pancreatic cancer may represent ovarian metastasis of the primary tumor.

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Section: Discussionmentioning

confidence: 45%

“…Pancreatic cancer rarely metastasizes to the ovaries [1]. It is also rare for metastatic ovarian cancers to cause ovarian torsion [2].…”

Section: Introductionmentioning

confidence: 99%

A Case of Ovarian Metastasis of Pancreatic Cancer Causing Ovarian Torsion

Tanabe¹,

Sugino²,

Ichida³

et al. 2022

Cureus

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“…Elevated CA-125 points toward an ovarian neoplasm, while CA 19-9 is commonly used to identify pancreatic cancer and monitor for disease progression. CA-125 levels greater than 75 U/ml were associated with decreased 5-year survival [8,9].…”

Section: Discussionmentioning

confidence: 98%

Krukenberg Tumor Secondary to Pancreatic Ductal Adenocarcinoma: A Case Report

Sosa¹,

Monroy²,

Lavariega³

et al. 2022

IJCICR

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Introduction: A metastatic tumor of the ovary known as Krukenburg Tumor (KT) is a mucin-rich signet-ring adenocarcinoma that arises from a gastrointestinal site in most cases and from other sites in less proportion. We describe a rare case presenting a Krukenberg tumor secondary to pancreatic ductal adenocarcinoma. Case Presentation: A 51-year-old female, who started her current condition 6 months ago, with 15 kg of weight loss, accompanied by nausea, vomiting, early satiety, and constipation. Computerized tomography showed dependent mass involving the body and tail of the pancreas with solid and cystic components, highly suggestive of a primary tumor as well as peritoneal carcinomatosis and a left ovarian mass, tumor (Krukenberg) as a first possibility. A laparoscopy was performed. The final pathology report was a pancreatic ductal adenocarcinoma with metastases to the ovary from the left salpingectomy. Conclusion: Pancreatic cancer presenting as Krukenberg tumor of the ovary is rare and easily misdiagnosed as primary ovary carcinomas, which leads to missed surgical opportunities. Resection of ovarian metastases combined with chemotherapy treatment may increase the overall survival even in patients with advanced pancreatic ductal adenocarcinoma.

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“…Eight studies were yielded from the systematic search and 8 patients were included. [5][6][7][8][9][10][11][12] The characteristics of all cases are summarized in Table 3. The summary and analysis of the clinicopathological characteristics from these cases may provide a comprehensive description for surgeons and gynecologists.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic cancer with ovarian metastasis: cases report and literature review

Zhou

Zhao

et al. 2023

Journal of Pancreatology

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Background: Pancreatic cancer with ovarian metastases is rare and easily misdiagnosed. Patients with ovarian metastases are first diagnosed with ovarian cancer and may miss the opportunity to receive surgical operation. We report 7 rare cases of ovarian metastases secondary to pancreatic adenocarcinoma and review the literature to analyze clinical characteristics, diagnostic methods, and potential therapeutic strategies for the rare malignancy.Cases Summary: We retrospectively analyzed the clinical data of 7 female patients with ovarian metastases of primary pancreatic cancer who were admitted to our hospital from January 01, 1985, to April 1, 2020. These 7 patients were diagnosed with ovarian metastasis at an average age of 52.28 (38-69) years. The reason for the patient's visit was generally a mass in the lower abdomen and/or abdominal pain. Six of them had significantly higher serum Carbohydrate antigen19-9 (CA19-9) levels, 6 patients had pancreatic tumors located in the body or tail, and 1 patient had one in the head of the pancreas. All patients underwent excision of ovarian tumors and resection or biopsy of pancreatic tumors. Five patients had pancreatic ductal adenocarcinoma (PDAC), and 2 had pancreatic cystadenocarcinoma (PCC), all of which were revealed by the pathological results. Ovarian tumors were assessed by pathology and were consistent with pancreatic metastasis. Currently, all 7 patients have died (follow-up to January 2, 2021). The median survival time for all patients was 13.7 months (2.9-27 months).Conclusions: For this rare tumor, elevated serum CA19-9 may indicate that the primary lesion is in the pancreas. Enhanced pancreatic Computed Tomography (CT) can facilitate diagnostic localization. In addition, if the pancreatic tumor cannot be removed, the ovarian tumor should still be resected to reduce the tumor load and improve the quality of life.

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Pancreatic cancer with ovarian metastases: A case report and review of the literature

Cited by 10 publications

References 35 publications

A Case of Ovarian Metastasis of Pancreatic Cancer Causing Ovarian Torsion

A Case of Ovarian Metastasis of Pancreatic Cancer Causing Ovarian Torsion

Krukenberg Tumor Secondary to Pancreatic Ductal Adenocarcinoma: A Case Report

Pancreatic cancer with ovarian metastasis: cases report and literature review

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