Pancreatic fat content is associated with β-cell function and insulin resistance in Chinese type 2 diabetes subjects

Lü, Ting; Wang, Yao; Dou, Ting; Xue, Bizhen; Tan, Yuanyuan; Jiao, Yang

doi:10.1507/endocrj.ej18-0436

Cited by 24 publications

(18 citation statements)

References 34 publications

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“…At present, the relationship between pancreatic fat deposition and T2DM is not clear. Both Chai et al [1] and Lu T [17] found that patients with T2DM had higher fat content in pancreas than that of healthy people, which agreed with the results in the current study. Fatty pancreas have a higher proportion of T2DM than non-fatty pancreas group, indicating that fatty pancreas may have association with T2DM…”

Section: Discussionsupporting

confidence: 92%

The correlation between type 2 diabetes and fat fraction in liver and pancreas: a study using MR Dixon technique

zhongshuai

et al. 2021

Preprint

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Background The increased obesity results in ectopic fat deposits in liver and pancreas.Ectopic fat deposits affect insulin resistance and blood sugar content with Type 2 Diabetes.To assess the relationship between obesity and ectopic fat deposits and diabetes,this study used MR Dixon method for the quantification of liver and pancreas fat fraction (FF) in T2DM patients and healthy controls. Methods The FF of liver and pancreas, the maximum diameters of the pancreas, SAT, VAT and TAT were measured for 167 subjects using the MR Dixon data.Four groups were established on the basis of BMI value.For statistics, intra-and inter-group comparison was done by employing Independent Sample t Test. Results ① The average fat content in liver and pancreas, the fat content in pancreas body and tail, and VAT in Group 1 were higher than those in Group 3 (P༜0.05). ② The average fat content in liver and pancreas, the adipose fraction of the pancreas head, and VAT in the Group 2 were higher than those in Group 4 (P༜0.05). ③ The average fat content of liver and pancreas, the adipose content of the body and the tail of the pancreas, the abdominal subcutaneous adipose area (SAT), the visceral adipose tissue area (VAT), and the total abdominal adipose tissue area (TAT) in Group 2 were higher than those in the Group 1 (P༜0.05). ④ The FF of pancreas tail, SAT and TAT in Group 4 were higher than those in Group 3 (P༜0.05). Conclusion The tissue FF,which has a close relationship with T2DM,can be assessed by MR Dixon technique.The results showed that all T2DM patients should pay attention to tissue fat content regardless of BMI values.

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Section: Discussionsupporting

confidence: 92%

The correlation between type 2 diabetes and fat fraction in liver and pancreas: a study using MR Dixon technique

zhongshuai

et al. 2021

Preprint

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“…Although the baseline analysis showed that PFC was not associated with β‐cell function, after 6 months of aerobic exercise intervention, we found that the reduction of PFC was a protective factor for β‐cell function. This finding was supported in some cross‐sectional studies 8,28,29 . In previous studies, PFC correlated negatively with β‐cell function.…”

Section: Discussionsupporting

confidence: 72%

“…This finding was supported in some cross-sectional studies. 8,28,29 In previous studies, PFC correlated negatively with β-cell function. Lim et al also reported that the decrease in total pancreatic fat was associated with a return of β-cell function.…”

Section: Discussionmentioning

confidence: 75%

Aerobic training reduces pancreatic fat content and improves β‐cell function: A randomized controlled trial using IDEAL‐IQ magnetic resonance imaging

Zheng

Miller

et al. 2022

Diabetes Metabolism Res

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Aims To explore the effects of six months of moderate‐intensity aerobic exercise on pancreatic fat content and its impact on β‐cell function. Materials and Methods A total of 106 patients with type 2 diabetes mellitus were randomized to either a moderate‐intensity aerobic training group (three times a week, including 5 min warm‐up, 50 min aerobic dancing, and 5 min relaxation, n = 53) or control group (n = 53) with 6‐month intervention. The primary endpoint was change in pancreatic fat content. An intention‐to‐treat analysis was conducted. Results Eighty‐six patients completed the study with 43 patients in the aerobic training group. The average age, HbA1c, and pancreatic fat content for all participants (106 patients) were 66.39 ± 5.59 years, 7.05 ± 1.24%, and 10.35 ± 9.20%, respectively. Nearly half (49.06%) of patients were males. Subjects in the aerobic training group saw a significant reduction in pancreatic fat content when compared to controls (p = 0.001). In logistic regression models containing age, diabetes duration, change in BMI, smoking/drinking status, changes in lipid indices, and other abdominal fat content, only reduction in pancreatic fat content (p < 0.05) was an independent protective factor for β‐cell function and HbA1c. Conclusions Six months of moderate‐intensity aerobic training significantly reduced the pancreatic fat content. The reduction of pancreatic fat content was an independent protective factor for β‐cell function and HbA1c.

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“…One study found that pancreatic fat was a stronger determinant of impaired insulin secretion in subjects with prediabetes [37]. Lu et al found that pancreatic fat content is associated with β-cell function in Chinese T2DM subjects [38]. Tushuizen et al also concluded that the pancreatic fat content was inversely associated with β-cell function in nondiabetic subjects [39].…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Fat is not significantly correlated with β-cell Dysfunction in Patients with new-onset Type 2 Diabetes Mellitus using quantitative Computed Tomography

Sang

Sun

et al. 2020

Int. J. Med. Sci.

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Objective: Type 2 diabetes mellitus (T2DM) is a chronic condition resulting from insulin resistance and insufficient β-cell secretion, leading to improper glycaemic regulation. Previous studies have found that excessive fat deposits in organs such as the liver and muscle can cause insulin resistance through lipotoxicity that affects β-cell function. The relationships between fat deposits in pancreatic tissue, the function of β-cells, the method of visceral fat evaluation and T2DM have been sought by researchers. This study aims to elucidate the role of pancreatic fat deposits in the development of T2DM using quantitative computed tomography (QCT), especially their effects on islet β-cell function. Methods: We examined 106 subjects at the onset of T2DM who had undergone abdominal QCT. Estimated pancreatic fat and liver fat were quantified using QCT and calculated. We analysed the correlations with Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) scores and other oral glucose tolerance test-derived parameters that reflect islet function. Furthermore, correlations of estimated pancreatic fat and liver fat with the area under the curve for insulin (AUCINS) and HOMA-IR were assessed with partial correlation analysis and demonstrated by scatter plots. Results: Associations were found between estimated liver fat and HOMA-IR, AUCINS, the modified β-cell function index (MBCI) and Homeostatic Model Assessment β (HOMA-β). However, no significant differences existed between estimated pancreas fat and those parameters. Similarly, after adjustment for sex, age and body mass index, only estimated liver fat was correlated with HOMA-IR and AUCINS. Conclusions: This study suggests no significant correlation between pancreatic fat deposition and β-cell dysfunction in the early stages of T2DM using QCT as a screening tool. The deposits of fat in the pancreas and the resulting lipotoxicity may play an important role in the late stage of islet cell function dysfunction as the course of T2DM progresses.

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Pancreatic fat content is associated with β-cell function and insulin resistance in Chinese type 2 diabetes subjects

Cited by 24 publications

References 34 publications

The correlation between type 2 diabetes and fat fraction in liver and pancreas: a study using MR Dixon technique

The correlation between type 2 diabetes and fat fraction in liver and pancreas: a study using MR Dixon technique

Aerobic training reduces pancreatic fat content and improves β‐cell function: A randomized controlled trial using IDEAL‐IQ magnetic resonance imaging

Pancreatic Fat is not significantly correlated with β-cell Dysfunction in Patients with new-onset Type 2 Diabetes Mellitus using quantitative Computed Tomography

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