Pancreatic gastrointestinal stromal tumor: A case report

Elgeidie, Ahmed; El-Magd, El-Sayed Abou; El-Maaty, Sara Raafat Abu; El-Hawary, Amira Kamal

doi:10.1016/j.ijscr.2016.08.019

Cited by 19 publications

(13 citation statements)

References 16 publications

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“…Radiology and medical imaging play a central part in evaluating pancreatic tumors. US, CT, magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS) are only some of the most common techniques that provide important medical imaging data regarding the tumor size and location, distant metastases, and invasion of adjacent anatomical structures, without being able to clearly indicate the histological type of the tumor itself [ 18 , 19 ], often making the differential diagnosis with other rare pathologies [ 20 ]. In addition, magnetic resonance spectroscopy (MRS) is another modern medical imaging method which can be used to detect intratumoral peak levels of certain metabolites [ 21 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

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An extremely uncommon case of pancreatic extragastrointestinal stromal tumor in a 53-year-old female patient

Ene

Florescu²,

Ene³

et al. 2022

Rom J Morphol Embryol

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Gastrointestinal stromal tumors (GISTs) are the most frequently encountered mesenchymal tumors that develop anywhere along the gastrointestinal (GI) tract, but they account for less than 1% of all GI tumors. However, GISTs can also develop outside the GI tract. They are referred to as extragastrointestinal stromal tumors (EGISTs) and represent around 5-10% of all GISTs. In this latter case, the tumor itself is not connected to the GI tract and can affect the omentum, mesentery, and retroperitoneum. EGISTs can also originate from the pancreas, but they are extremely uncommon. It is estimated that pancreatic EGISTs account for about 5% of all EGISTs, with around 30 cases being reported in the literature so far. The current report presents an extremely rare case of pancreatic EGIST encountered in a 53-year-old woman with no remarkable personal or family medical history. Surgical resection of the pancreatic head tumor through pancreaticoduodenectomy using Whipple procedure combined with negative resection margins and adjuvant Imatinib mesylate treatment led to a favorable postoperative evolution. The follow-up at six months after surgery did not reveal any malignant changes.

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Section: ⧉ Discussionmentioning

confidence: 99%

“…HP results can differentiate three types of GISTs: ( i ) spindle type; ( ii ) epithelioid type; ( iii ) mixed type. The spindle type is the most frequently encountered in pancreatic EGISTs [ 18 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

An extremely uncommon case of pancreatic extragastrointestinal stromal tumor in a 53-year-old female patient

Ene

Florescu²,

Ene³

et al. 2022

Rom J Morphol Embryol

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“…A total of 17 patients who were confirmed as pancreatic GISTs after resection were collected in this study. 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 The clinicopathological features and outcomes of these cases are summarized in Table 1 . Age of these patients ranged from 30 to 74 years (median, 54.7 years; mean, 53.1 years).…”

Section: Discussionmentioning

confidence: 99%

Extra-gastrointestinal stromal tumor of the pancreas: report of a case

Kwon

2017

Ann Hepatobiliary Pancreat Surg

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Gastrointestinal tumors (GISTs) of the pancreas are extremely rare with limited individual case reports and small number of case series. Herein, we report a case of pancreatic extragastrointestinal stromal tumor (EGIST) along with literature review. A 64-year-old female patient was referred to us for treatment of an abdominal mass detected by ultrasonographic examination. The tumor was located in the periamullary region. Under a preoperative diagnosis of a duodenal GIST, we performed a pylorus preserving pancreatoduodenectomy for this lesion. Laboratory examination results were within normal ranges. On pathologic gross examination, the tumor measured at 7 cm in its greatest dimension almost entirely involved the pancreatic head. Its cut surface was rubbery and white. It was surrounded by a thin pseudocapsule and well demarcated. Histopathological examination of the specimen showed a cellular lesion with compressed pancreatic tissue at peripheral. Mitotic count was 5 per 50 high-power fields. Immunohistochemically, neoplastic cells were positive for antibodies against C-KIT (CD117), CD 34, and vimentin. However, smooth-muscle actin reactions with antibodies against S-100 or desmin were negative. Based on above findings, the tumor was finally diagnosed as GISTs originating from the pancreas. The patient has been followed up postoperatively for 72 months. There is no evidence of recurrence. Here we report this case of pancreatic EGIST presenting as a solid neoplasm along with literature review of cases previously described. Our review on pancreatic EGISTs is limited and insufficient to make a conclusion regarding its clinical features. Those manifested large masses tended to have an aggressive biological and clinical behavior. Thus, pancreatic EGISTs need to be carefully differentiated. Adequate surgical intervention is necessary for pancreatic EGISTs.

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“…In descending order of frequency, occurrences in the stomach, small bowel, large bowel, and esophagus make up over 85% of GISTs [1]. Extragastrointestinal stromal tumors (eGISTs) make up 5-10% of GISTs, with the disease of the pancreas accounting for 5% of these cases [2]. Immunohistochemical staining is useful for diagnosis, as positivity for CD117 confirms the diagnosis of GIST [1].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2019

Journal of Case Reports: Open Access

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Background: Extragastrointestinal stromal tumors are unusual, with those arising in the pancreas even more so. Because extragastrointestinal stroma tumors involving the pancreas may present nonspecifically as an upper gastrointestinal bleed, it is important to adequately work up the patient to rule out malignancy to optimize the outcome for the patient. While surgery with complete resection of the tumor is the treatment of choice, it is important to consider the role of tumor markers in targeted therapy for a nonresectable disease or nonsurgical patients. Case presentation:We describe a 53-year old man with a history of neurofibromas and irritable bowel syndrome who presented with abdominal pain and persistent iron deficiency anemia. He was found to have an extragastrointestinal stromal tumor of the pancreas, which stained positive for CD117 and DOG1. The treatment plan for this patient is targeted therapy with Imatinib, a tyrosine kinase inhibitor effective in the treatment of CD117+ cancer cells, followed by possible surgical resection. Conclusions:The pancreatic extragastrointestinal stromal tumor is a rare malignancy that can present with acute, nonspecific findings of a gastrointestinal bleed including anemia, fatigue, and melanotic bowel movements. With adequate history and physical examination, we can appropriately work up a patient with this rare disease and develop an appropriate treatment plan for the patient.

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Pancreatic gastrointestinal stromal tumor: A case report

Cited by 19 publications

References 16 publications

An extremely uncommon case of pancreatic extragastrointestinal stromal tumor in a 53-year-old female patient

An extremely uncommon case of pancreatic extragastrointestinal stromal tumor in a 53-year-old female patient

Extra-gastrointestinal stromal tumor of the pancreas: report of a case

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