Pancreatic Islet Beta-Cell Apoptosis in Experimental Diabetes Mellitus

Смирнов, А. В.; Снигур, Г Л; Воронкова, М П

doi:10.5772/51411

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…The induction of STZ could change the pancreatic morphology of rats. Depreciation of Langerhans islet in diabetic rats might be caused by the loss of β-cell, which allegedly was caused by the alkylation and activity of NO STZ radical in DNA cell (Smirnov et al 2012). The morphology of Langerhans islet has been reported by Wu et al (2016).…”

Section: Discussionmentioning

confidence: 95%

Antihyperglycemic Activity of Java Tea-Based Functional Drink-Loaded Chitosan Nanoparticle in Streptozotocin-Induced Diabetic Rats

et al. 2021

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Functional drinks containing the leaves of Java tea has been shown to offer many health functionalities, particularly to lower blood glucose levels, due to its bioactive compounds. Nanoencapsulation technology was reported being able to protect these bioactive compounds and also enhance their bioavailability. This study examined the use of nanoencapsulation techniques to improve the bioavailability of Java tea-based functional effervescent drink and enhance its antihyperglycemic activity. Three versions were prepared in this study: ready to drink (RTD) as the control, microencapsulated, and nanoencapsulated. They were all measured for their total phenolic content (TPC) before being tested for their antihyperglycemic activity. The TPC of RTD, microencapsulated, and nanoencapsulated Java tea-based functional drinks (JTFD) were 998,425, 735,433, and 663,517 ppm, respectively. The antihyperglycemic activities were evaluated by feeding each beverage to streptozotocin-induced diabetic Sprague Dawley rats for fourteen days. Nanoencapsulated JTFD was found to be more superior than the other two formulations to decrease the blood glucose level (7.98%), maintain the feed intake, body weight, improve the viability of Langerhans and beta-cells by 49.09%, 32.50%, respectively.

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Section: Discussionmentioning

confidence: 95%

Antihyperglycemic Activity of Java Tea-Based Functional Drink-Loaded Chitosan Nanoparticle in Streptozotocin-Induced Diabetic Rats

et al. 2021

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“…ALX produces a reduction in β-cells, and STZ induces marked necrotic changes in the pancreas with a reduction of β-cells and hyperplasia of the nucleus (Dunn et al 1943, Smirnov et al 2012). In our study (Table 6), larger areas of islets and more significant number of β-cells were found in the groups that received WAQE.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Hypoglycemic Effects of Watercress (Nasturtium Officinale) Extracts in Diabetic Rats

Fenton-Navarro¹,

Martínez²,

Castro³

et al. 2018

Afr J Tradit Complement Altern Med

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Background: Watercress is a semi-aquatic plant used in traditional medicine to treat various ailments, such as flu, cough, avitaminosis, and anorexia; it is also used as a diuretic and for hypoglycemia treatment in diabetes. In this study, we report the antioxidant and hypoglycemic activity of orally administered aqueous (WAQE), acetonic (WAE), and alcoholic (WOHE) watercress extracts. The effect of subchronic administration of watercress extracts on oxidative stress was also studied. Materials and Methods: WAQE, WAE, and WOHE were obtained and administered orally. Alloxan (200 mg/kg) and streptozotocin (60 mg/kg) were applied to induce hyperglycemia in male Wistar rats. Phenolic and flavonoid content, as well as antioxidant activity of the extracts were measured. The acute and subchronic effects (8 weeks) of WAQE were evaluated. The activity of antioxidant enzymes levels of malondialdehyde, hepatic enzyme markers in the serum, and renal function markers, were assessed. Histopathological evaluation of the pancreas, kidney, and liver was performed using hematoxylin-eosin staining. Results: Watercress extracts have high concentrations of phenols, polyphenols, and flavonoids, in addition to a very high antioxidant effect. The hypoglycemic effect of WAQE upon acute administration was 76.6% higher than that of insulin. When administered chronically, glucose levels were normalized on the third week up to the eighth week. Furthermore, the antioxidant enzymes and biochemical parameters improved. Conclusion: WAQE administration to diabetic rats reduced oxidative stress damage and decreased glucose levels. This study supports the use of this plant for the treatment of diabetes.

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“…(2012) 41 reported that STZ-induced diabetic mice caused necrotic cells and reduced the number of β-cells in each Langerhans islet significantly. HW administration showed an improvement on the pancreas histology, suggesting the reduction of necrotic cells and the increase in the number of cells in the Langerhans islet compared to the DM group without treatment (Figure 2).…”

Section: Hydrogen-rich Water Restored Necrotic Cells Of the Pancreas In Diabetic Ratsmentioning

confidence: 99%

Hydrogen-Rich Water Ameliorates Pancreatic Cell Necrosis and Regulates Cytokine Levels in Streptozotocin-Induced Diabetic Rats

2021

TJNPR

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Water is a vital component for the body, especially for maintaining a healthy body and preventing various diseases. 1 Lack of water intake may lead to dehydration and increase the risk of various diseases such as headaches, urolithiasis, obesity, and diabetes mellitus. 1,2 According to Goodman, drinking more water is linked to a reduction in body weight. 2 Adequate water consumption is better than a fiber diet in a 24-week weight loss program in overweight and obese women. 3,4 Consumption of 1 L of water daily for three months and 0.8 L of water daily for six months significantly reduced fasting blood glucose. 5 More water intake can treat obesity. Adequate water consumption could affect the removal of excess glucose in the kidney by creating more urine. Dehydration is associated with an increase in blood glucose level caused by the inability to excrete glucose in the urine. 1 Diabetes mellitus (DM) is a metabolic disease that disrupts the metabolism of carbohydrates, fats, and proteins characterized by an increase in the normal level of blood glucose. 6 The prevalence of diabetes has increased over the decades. 7 Diabetic patients accounted for 463 million (9.3% of the world's population) in 2019, with ages ranging from 20 to 79 years, and this figure is anticipated to rise to 700 million (10.9%) by 2045. 7,8 The increasing prevalence of people with diabetes is also higher in low and middle-income countries compared with high-income countries. 9

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Pancreatic Islet Beta-Cell Apoptosis in Experimental Diabetes Mellitus

Cited by 4 publications

References 16 publications

Antihyperglycemic Activity of Java Tea-Based Functional Drink-Loaded Chitosan Nanoparticle in Streptozotocin-Induced Diabetic Rats

Antihyperglycemic Activity of Java Tea-Based Functional Drink-Loaded Chitosan Nanoparticle in Streptozotocin-Induced Diabetic Rats

Antioxidant and Hypoglycemic Effects of Watercress (Nasturtium Officinale) Extracts in Diabetic Rats

Hydrogen-Rich Water Ameliorates Pancreatic Cell Necrosis and Regulates Cytokine Levels in Streptozotocin-Induced Diabetic Rats

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