Pancreatic Lipase Inhibitor from Food Plant: Potential Molecule for Development of Safe Anti-obesity Drug

Biological functionality and characteristics of Jerusalem artichoke (Helianthus tuberosus L.) tuber extracts

“…Given that JAE's in vitro inhibitory impact on lipase is demonstrated, it may be useful for limiting fat digestion, lowering body weight in obese people, and improving the metabolic state of humans. Numerous plant extracts have been reported to exhibit lipase inhibitory activity (Gowadia and Vasudevan, 2000;Mhatre et al, 2016), and the outcome suggests that the plant having abundant polyphenolic contents does have gastral inhibitory activity, thus supporting the findings of this study.…”

Cocoa (Theobroma cacao L.) Seed Proteins’ Anti-Obesity Potential through Lipase Inhibition Using In Silico, In Vitro and In Vivo Models

“…Thus, PL inhibition results in a decrease of digestion and absorption of triglycerides [ 33 , 34 ]. Besides, the main reason for using PL inhibitors is their action in the gastrointestinal tract, which could reduce some side effects and other health complications associated with current prescribed anti-obesity drugs such as phentermine, diethylpropion, topiramate, and zonisamide [ 4 ].…”

“…Nowadays, the only PL inhibitor approved by the Food and Drug Administration (FDA) is orlistat (tetrahydrolipstatin), recommended for long-term use to reduce the absorption of dietary fat. However, its use has been associated to multiple side effects, including allergic reactions, such as hives, bowel urgency, and gas stomach pain, difficulty in breathing, diarrhea, nausea, vomiting, oily bowel movements, swelling of face, throat, tongue, and rectal pain [ 4 ]. Natural compounds derived from foods such as proteins and peptides could have a positive impact on the functions and conditions of human health [ 5 , 6 ].…”

Characterisation of pancreatic lipase inhibitors from Brassica rapa L. ssp. chinensis

“…Among these compounds, saponins and polyphenols have shown potent lipase inhibitory activities, indicating that lipase inhibitors derived from edible plants hold great promise as effective anti-obesity treatments. 3 For example, citrus peels (grapefruit, pomelo, kumquat, lemon and orange) contain phenolic compounds that showed a strong inhibitory effect on pancreatic lipase, with an IC 50 value ranging from 87 to 292 mg L −1 , as compared to orlistat (0.103 ± 0.004 mg mL −1 ). 4 The results indicated that hesperidin was the compound responsible for the inhibitory effect.…”