Pancreatic Polypeptide and Intestinal Migrating Motor Complex in Humans

Owyang, Chung; Achem-Karam, Sami R.; Vinik, Aaron I.

doi:10.1016/s0016-5085(83)80160-7

Cited by 53 publications

(5 citation statements)

References 24 publications

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“…In the case of serotonin, even higher doses are necessary to increase the numbers of phase III contractions 20 . The evidence of a role of pancreatic polypeptide is contradictory 23 , 24 . In a dose of 600 or 1200 pmol kg –1 infused over 200 min, neurotensin inhibited the occurrence of the MMC and changed the motility pattern from a fasting‐type to a fed‐type 25 .…”

Section: Discussionmentioning

confidence: 99%

“…Intravenous infusion of motilin induces motor activity similar to the spontaneous MMC and motilin plasma concentrations fluctuate in correlation with phases III 14 –19 . Other peptides possibly involved in the regulation of interdigestive and postprandial intestinal motility are serotonin, 20 somatostatin, 21 , 22 and pancreatic polypeptide 23 , 24 . Neurotensin, a peptide with an amino acid sequence closely related to xenin has been shown to change the duodenal motility pattern of human volunteers from a fasting type to a fed type when infused continuously 25 …”

Section: Introductionmentioning

confidence: 99%

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Phase III of the migrating motor complex: associated with endogenous xenin plasma peaks and induced by exogenous xenin

Feurle¹,

Pfeiffer

Schmidt

et al. 2001

Neurogastroenterology Motil

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Xenin, a recently discovered peptide produced by specific endocrine cells of the duodenal mucosa, has shown exocrine, endocrine and motility effects in the gastroenteropancreatic system in animal experiments. The aim of the present investigation was to study the role of xenin in the regulation of duodenojejunal motility of humans. Twenty-nine healthy volunteers from the hospital staff gave informed consent to participate in this investigation. In 20 volunteers, we determined plasma concentrations of immunoreactive xenin at 15 min intervals over a mean time period of 8 h fasting and recorded the interdigestive motor activity of the duodenojejunum. In a double-blind randomized crossover study on other nine subjects, synthetic xenin in a dose of 4 pmol kg-1 min-1 or placebo was infused for 10 min intravenously in the interdigestive period and postprandially after a liquid meal. Duodenojejunal motility was recorded simultaneously. Predefined interdigestive xenin plasma peaks were found to be significantly associated with the phases III of the migrating motor complex. In the interdigestive period, xenin induced a premature phase III activity in each volunteer; this was followed by a second phase III in five out of nine subjects. In the postprandial state, xenin significantly increased contraction frequency and the percentage of aborally propagated contractions. These findings suggest a role of the peptide hormone xenin in modulating interdigestive and postprandial duodenojejunal motility in humans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phase III of the migrating motor complex: associated with endogenous xenin plasma peaks and induced by exogenous xenin

Feurle¹,

Pfeiffer

Schmidt

et al. 2001

Neurogastroenterology Motil

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“…These variations in pancreatic-polypeptide concentration have been linked to phase 3 activity in the stomach as well as to the level of gastric acid secretion (Schwartz et al 1979). However, in man pancreaticobiliary secretion, pancreatic-polypeptide release and intestinal motor activity during the interdigestive period may be causally related (Owyang et al 1983). Intravenous infusion of pancreatic polypeptide increases the frequency of jejunal MMC in both dogs and pigs (Bueno et a1.…”

Section: B L O O D H O R M O N E F L U C T U a T I O N S A N D G A S mentioning

confidence: 99%

Hormonal Control of Gut Motility in Ruminants and Non-Ruminants and Its Nutritional Implications

Fioramonti¹,

Buéno²

1988

Nutr. Res. Rev.

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“…Beglinger et al infused only one dose of secretin and compared the secretin-induced protein output with basal output. It is well known that basal pancreatic secretion undergoes important fluctuations in relation to interdigestive migrating motor complex and that a marked increase of enzyme secretion occurs during phase 2 and early phase 3 of the complex.5 6 Because of these marked fluctuations, taking basal secretion as a control secretion in this type of study could be very unreliable. In this connection, it would be of interest to know during which phase of the interdigestive motor complex Beglinger et al began the secretin infusion.…”

Section: (4) With Regard To the Work Of Domschke Et Ap4mentioning

confidence: 99%

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Gullo¹

1985

Gut

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Pancreatic Polypeptide and Intestinal Migrating Motor Complex in Humans

Cited by 53 publications

References 24 publications

Phase III of the migrating motor complex: associated with endogenous xenin plasma peaks and induced by exogenous xenin

Phase III of the migrating motor complex: associated with endogenous xenin plasma peaks and induced by exogenous xenin

Hormonal Control of Gut Motility in Ruminants and Non-Ruminants and Its Nutritional Implications

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