Pancreatic Schwannoma: Literature Review

Gupta, Aditya; Subhas, Gokulakkrishna; Mittal, Vijay K.; Jacobs, Michael J.

doi:10.1016/j.jsurg.2008.12.001

Cited by 34 publications

(24 citation statements)

References 32 publications

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“…Antoni A regions are hypercellular and composed of tightly packed spindle cells with occasional nuclear palisading and Verocay bodies. Antoni B regions are hypocellular with degenerative changes; tumor cells are more spread out in a myxoid stroma (Gupta et al, 2009). This explains the solid and cystic appearance of schwannomas on CT scan, corresponding to the presence of Antoni A and B areas, respectively (Wu et al, 2005;Ferrozzi et al, 1995).…”

Section: Discussionmentioning

confidence: 97%

“…While neurofibromas have nerve fascicles running through the tumor, schwannomas have nerve fascicles running alongside the tumor. Characteristics of Schwann cells that aid in identification include the presence of the S-100 antigen and the potential for melanocytic differentiation; other indicatory antigens include vimentin, CD56 and, occasionally, CD57, and glial fibrillary acidic protein (Gupta et al, 2009). Schwannomas are composed histologically of Antoni A and Antoni B areas.…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Cystic Schwannoma of the Portal Triad

Avgerinos

Heenatigala²,

Lo³

2016

EJBM

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Schwannomas can occur anywhere throughout the body andhave often been mistaken for more-sinister lesions, especiallywhen found in relation to the pancreas. Clinical symptomsrange from none to vague abdominal pain, back pain,anorexia, weight loss, vomiting, jaundice, and episodes ofcholangitis and gastrointestinal bleeding. Preoperative diagnosisis difficult, and endoscopic ultrasound with fine-needleaspiration is often limited in specificity. Given the low statisticallikelihood of schwannomas, therapy is usually targeted at thepossibility of pancreatic cystadenoma/cystadenocarcinoma.Simple enucleation is usually the preferred treatment, anddiagnosis can be established at the time of operation by frozensection. Schwannomas can be malignant, but preoperativeimaging and pathology can help establish the benign natureof most specimens. Patients typically do well with resolution ofsymptoms. Here we present the case of a patient with abdominalpain and a peripancreatic mass observed with computedtomography, who was found to have a cystic schwannomaextending from the portal triad. The mass was removed andthe patient was discharged without complications.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

A Rare Case of Cystic Schwannoma of the Portal Triad

Avgerinos

Heenatigala²,

Lo³

2016

EJBM

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“…Schwannomas are characterized by two histologic components: Antoni A and Antoni B areas. Antoni A area is hypercellular and characterized by closely packed spindle cells with nuclear palisading and Verocay bodies, whereas Antoni B area is hypocellular with degenerative changes and has loosely arranged tumor cells [1]. Antoni A area shows a high density and heterogenous appearance due to high cellularity and increased lipid content.…”

Section: Discussionmentioning

confidence: 99%

“…Pancreatic schwannomas are rare. Pancreatic schwannomas have a wide variety of imaging findings and tend to be confused with other pancreatic tumors [1]. Herein we describe a case of asymptomatic pancreatic schwannoma that was incidentally detected by computed tomography (CT) and showed increased fluorin-18 fluorodeoxyglucose (FDG) uptake.…”

Section: Introductionmentioning

confidence: 98%

A case of pancreatic schwannoma showing increased FDG uptake on PET/CT

Fukuhara

Fukuda

Tazawa

et al. 2017

International Journal of Surgery Case Reports

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HighlightsPancreatic schwannoma is rare and preoperative diagnosis is difficult due to the lack of specific symptoms, radiological characteristics and tumor markers.Incidental detection of pancreatic schwannoma is predicted to increase due to the widespread use of CT and MRI. It is important to take into account this tumor in the differential diagnosis of pancreatic tumors.We should be aware that FDG-PET/CT shows abnormal accumulation in a benign pancreatic schwannoma.

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“…Pancreatic schwannomas are of neurogenic origin tumour arising from sympathetic or parasympathetic fibers. Pancreas is an one of very uncommon location for schwannomas and predominantly seen in adults, with an equal sex distribution [2]. We report a rare case of pancreatic schwannoma localized in head and uncinate process, presenting with features of pain upper abdomen with gastric outlet obstruction.…”

Section: Introductionmentioning

confidence: 95%

Pancreatic Schwanoma Presenting as Gastric Outlet Obstruction- A Rare Presentation

Jayant¹,

Agrawal²,

Agarwal³

2014

AJCMR

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Introduction: Schwannoma is a very uncommon pancreatic neoplasms. Because of their varing size, cystic nature they mimic pancreatic cystic neoplasms. Mostly definitive diagnosis is confirmed with histological assessment post resection. The mainstay of treatment is surgical resection based on the nature of tumour. Case presentation: Here we are reporting a very rare case of pancreatic schwannoma in 45 year old female presenting with pain upper abdomen with projectile vomiting. Pre-operative diagnosis of heterogenous tumor arising from head of pancreas was made on CECT abdomen following which Whipple's procedure was performed. Post operative histological analysis showed spindle cells arranged in palisading pattern with S-100 positivity, confirms the diagnosis of pancreatic schwannoma. Conclusion: We conclude that pancreatic schwannoma must be considered as an important differential diagnosis of pancreatic neoplasms. Though they have non specific symptoms but can present in unusual way as gastric outlet obstruction. Pre-operative diagnosis is difficult though computed tomographic and magnetic resonance imaging may be of value. For benign tumors, simple enucleation is enough, while malignant tumors requires complete oncological resection.

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Pancreatic Schwannoma: Literature Review

Cited by 34 publications

References 32 publications

A Rare Case of Cystic Schwannoma of the Portal Triad

A Rare Case of Cystic Schwannoma of the Portal Triad

A case of pancreatic schwannoma showing increased FDG uptake on PET/CT

Pancreatic Schwanoma Presenting as Gastric Outlet Obstruction- A Rare Presentation

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