Pancreatic Schwannoma on FDG PET/CT

Wang, Xuezhu; Lv, Jingqiao; Fu, Chao; Chang, Xiaoyan; Huo, Li

doi:10.1097/rlu.0000000000003229

Cited by 5 publications

(9 citation statements)

References 17 publications

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“…To date, all 5 cases of pancreatic schwannoma that underwent PET/CT had increased FDG uptake. [8,17,23,29] Recently, an increasing number of cases have undergone endoscopic ultrasound fine needle aspiration (EUS-FNA), which has greatly contributed to precise preoperative diagnosis. Of the 12 patients with pancreatic schwannoma who underwent EUS-FNA, 9 were accurately diagnosed.…”

Section: Discussionmentioning

confidence: 99%

“…On 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), elevated FDG activity in schwannomas has been reported, [90] even though they are usually benign. To date, all 5 cases of pancreatic schwannoma that underwent PET/CT had increased FDG uptake [8,17,23,29] . Recently, an increasing number of cases have undergone endoscopic ultrasound fine needle aspiration (EUS-FNA), which has greatly contributed to precise preoperative diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Successful treatment of pancreatic schwannoma by enucleation

Zhou

Wei

et al. 2022

Medicine

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Rationale: Pancreatic schwannomas are extremely rare and are difficult to diagnose preoperatively. Over the past 50 years, only 96 cases of pancreatic schwannoma have been reported in English literature. Herein, we report a case of pancreatic schwannoma treated with enucleation.Patient concerns: A 66-year-old woman visited a local hospital due to ventosities. Ultrasonography and computed tomography revealed a pancreatic mass. She visited our hospital for further diagnosis and treatment.Diagnosis and interventions: Magnetic resonance imaging revealed a tumor in the pancreatic body, and a solid pseudopapillary tumor was considered preoperatively. During the surgery, a pancreatic mass was found growing in the pancreatic body and tail. A successful tumor enucleation was performed. The mass was 7 Â 6 Â 3 cm in size with a thin capsule. Pathological examination revealed that the tumor was mainly composed of spindle-shaped cells with a palisading arrangement and no atypia. Both hypercellular and hypocellular areas were visible. Immunohistochemical staining showed that protein S-100 was strongly positive. The tumor was diagnosed as a benign schwannoma originating from the pancreatic body and tail.Outcomes: Postoperatively, the patient showed good recovery. During the 24-month follow-up period, the patient remained well and free of complications.Lessons: Pancreatic schwannomas are extremely rare and difficult to diagnose using imaging examinations. Enucleation is a safe and efficacious treatment for exophytic pancreatic schwannomas.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Successful treatment of pancreatic schwannoma by enucleation

Zhou

Wei

et al. 2022

Medicine

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“…This is similar to other pancreatic tumors. Imaging modalities, including CT, MRI, and endoscopic ultrasound, can help to identify the pancreatic mass but cannot distinguish pancreatic schwannoma from other tumor types of the pancreas because of its wide range of morphologies [4]. Pancreatic schwannoma might appear as a solid, cystic, or as compound lesion [2,[5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…When pancreatic schwannoma appears as a mixed lesion of solid and cystic components, it resembles malignant pancreatic tumors and can be perceived that way even though pancreatic schwannoma is benign in the majority of cases. Some studies have shown that pancreatic schwannomas are also highly metabolic and light up on positron emission tomography-computed tomography scans, which also might be mistaken for malignancy [4,9]. This similarity might pose a risk for possible misdiagnosis and inappropriate management in some cases.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Pancreatic Schwannoma

Tambovtseva¹,

Ashraf²,

Suleiman³

et al. 2022

Cureus

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Pancreatic schwannoma is a neuroendocrine cell tumor that arises in the pancreas. It is very rare, and, to date, only fewer than 70 similar cases have been reported in the literature. Here, we present another case of this type of tumor in a 68-year-old female.In addition to describing the pancreatic schwannoma, we discuss the major challenges associated with its diagnosis and management. As such, clinically and on imaging, pancreatic schwannomas are almost indistinguishable from other cancerous or benign pancreatic tumors. Therefore, only a biopsy can definitively diagnose pancreatic schwannomas by demonstrating spindle-shaped cells with immunohistochemistry positive for S-100.Because pancreatic schwannomas are very rare, it is important to increase awareness among clinicians about this condition and inform them regarding the challenges associated with its diagnosis and management.

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“…[6][7][8][9][10] The false-positive 18 F-FDG uptake in the schwannomas, especially in those with unexpected location, are easily lead to the misinterpretation of schwannomas as malignancy in the imaging diagnosis. [11][12][13][14][15] PS arising from the pelvis is an extremely rare subtype of schwannoma, thus the literature on its 18 F-FDG PET/MRI findings was limited. For this reason, we report the findings on 18 F-FDG PET/MRI of this rare case of pelvic PS to provide further insight into diagnosing this kind of rare tumor.…”

Section: Figurementioning

confidence: 99%

Pelvic Plexiform Schwannoma on 18F-FDG PET/MRI

et al. 2021

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Plexiform schwannoma (PS), a subtype of schwannoma, is a rare benign nerve sheath tumor characterized by a multinodular plexiform growth pattern. It is usually confined to the head and neck or skin. Pelvic PS is an extremely rare occurrence and signifies a challenge for the imaging diagnosis. In this work, we present a 42-year-old woman with pelvic PS, who was initially suspected of malignant tumor on 18 F-FDG PET/MRI but confirmed as PS by postoperative pathology. We consider that this case would contribute to the literature and provide a further insight into diagnosing this kind of rare tumor.

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Pancreatic Schwannoma on FDG PET/CT

Abstract: A 55-year-old woman underwent FDG PET/CT to evaluate a pancreatic mass. The images showed elevated FDG activity in the uncinated process of the pancreas, suggestive of malignancy. However, pathological examination from the resected lesion demonstrated pancreatic schwannoma.

Cited by 5 publications

References 17 publications

Successful treatment of pancreatic schwannoma by enucleation

Successful treatment of pancreatic schwannoma by enucleation

A Rare Case of Pancreatic Schwannoma

Pelvic Plexiform Schwannoma on 18F-FDG PET/MRI

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