Pancreatic stone protein and soluble CD25 for infection and sepsis in an emergency department

Guadiana-Romualdo, Luis García de; Berger, Mario; Jiménez-Santos, Enrique; Rebollo-Acebes, S.; Jiménez-Sánchez, R.; Esteban-Torrella, Patricia; Hernando-Holgado, Ana; Ortin‐Freire, A.; Albaladejo-Otón, María Dolores

doi:10.1111/eci.12732

Cited by 29 publications

(39 citation statements)

References 41 publications

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“…The value of PSP to predict in-hospital mortality in patients with severe sepsis and septic shock requiring ICU management has been further demonstrated by Que et al [37], who also highlighted in another research that a model combining severity scores with PCT and PSP improves mortality prediction in these patients [38]. The clinical accuracy of PSP to identify sepsis and multiple organ dysfunction was also confirmed in a cohort of unselected, heterogeneous patients admitted to intensive or high-dependency care unit [32], as well as on a cohort of patients presenting to ED with suspicion of infection [35].…”

Section: Diagnostic and Prognostic Performance Of Psp In Sepsismentioning

confidence: 84%

Measurement of Pancreatic Stone Protein in the Identification and Management of Sepsis

Eggimann

Que

Rebeaud³

2019

Biomark. Med.

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Sepsis is a life-threatening syndrome characterized by a dysregulated host response to an infection resulting in multiple organ dysfunctions. Early diagnosis and management of sepsis is key to improve patient outcome but remains challenging. Despite extensive research, only few biomarkers have so far proven to be helpful in the diagnosis of sepsis. A novel protein biomarker, the pancreatic stone protein (PSP), is showing great promises. Several lines of evidences suggest that PSP has a higher diagnostic performance for the identification of sepsis than procalcitonin and C-reactive protein, and a strong prognostic value to predict unfavorable outcome at admission to intensive care unit. This review summarizes the current knowledge on the molecular mechanisms of PSP function and the clinical evidences available to highlight the relevance of this protein in the diagnosis and prognosis of sepsis.

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Section: Diagnostic and Prognostic Performance Of Psp In Sepsismentioning

confidence: 84%

Measurement of Pancreatic Stone Protein in the Identification and Management of Sepsis

Eggimann

Que

Rebeaud³

2019

Biomark. Med.

View full text Add to dashboard Cite

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“…Soluble CD25 also showed a good sensitivity and specificity in predicting mortality (26). García de Guadiana-Romualdo et al used CD25 as an infection and sepsis marker in 152 patients with suspected sepsis and found a similar performance than procalcitonin (27). Monneret et al found a higher expression of CD25 in sepsis non-survivors in comparison with survivors.…”

Section: Resultsmentioning

confidence: 99%

Flow Cytometry of CD64, HLA-DR, CD25, and TLRs for Diagnosis and Prognosis of Sepsis in Critically Ill Patients Admitted to the Intensive Care Unit: A Review Article

et al. 2018

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Sepsis is an important health problem with a high burden on health systems. Finding new aspects of immune system function in sepsis showed a new role for flow cytometry in the diagnosis of sepsis. We made a review on the role of CD64, HLA-DR, CD25, and TLRs as more useful flow cytometric tools in diagnosing sepsis, both in adults, and neonates. According to our results, we concluded that for diagnosis and treatment of the septic, flow cytometry can play an important role so that it can be used as a novel method in individualized treatment of septic patients based on their immune system situation.

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“…Furthermore, some other studies revealed the predictive value of serum LDH to short-term mortality in sepsis [22,23]. Some studies have confirmed that sIL-2R can be used for the early diagnosis of bacterial infection-related systemic inflammatory response syndrome, and high levels of sIL-2R in patients with sepsis are usually associated with the severity of the disease and are independent predictors of poor prognosis [24][25][26]. We also confirmed that sIL-2R was an independent risk factor for the short-term prognosis of HBV-ACLF patients with bacterial infection.…”

Section: Discussionmentioning

confidence: 96%

Establishment and validation of a prognostic model for hepatitis B virus‑related acute-on-chronic liver failure patients with bacterial infection

et al. 2021

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Background Bacterial infection is one of the most frequent complications in acute-on-chronic liver failure (ACLF), which leads to high mortality. However, a specific prognostic model for ACLF patients with bacterial infection has not been well established. Aim To establish and validate a nomogram for predicting 30-day mortality of hepatitis B virus-related ACLF (HBV-ACLF) patients with bacterial infection. Methods A total of 513 ACLF patients for HBV reactivation were enrolled in the prospective cohort, and 224 patients with bacterial infection were for derivation. Independent predictors were identified using multivariate logistic model and then assembled into a nomogram to predict 30-day mortality. The performance of the nomogram was assessed based on its calibration, discrimination and clinical utility in a retrospective cohort of 192 HBV-ACLF patients with bacterial infection. Results Age, total bilirubin, lactate dehydrogenase, international normalized ratio and soluble interleukin-2 receptor were shown to be independent risk factors for 30-day mortality of HBV-ACLF patients with bacterial infection and the nomogram was constructed. The nomogram showed a good calibration and discrimination in the derivation cohort, with an area under the receiver operating characteristic curve (AUC) of 0.883. Application of the nomogram in the validation cohort also showed a good calibration and discrimination, with the AUC of 0.852. Decision curve analysis confirmed the clinical utility of the nomogram. ConclusionThe nomogram was established and validated for predicting 30-day mortality of HBV-ACLF patients with bacterial infection, which may facilitate optimal therapeutic strategies to improve the prognosis of these patients.

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Pancreatic stone protein and soluble CD25 for infection and sepsis in an emergency department

Abstract: Pancreatic stone protein and sCD25 perform well as infection and sepsis biomarkers, with a similar performance than PCT, in ED patients with suspected infection. Further larger studies investigating use of PSP and sCD25 are needed.

Cited by 29 publications

References 41 publications

Measurement of Pancreatic Stone Protein in the Identification and Management of Sepsis

Measurement of Pancreatic Stone Protein in the Identification and Management of Sepsis

Flow Cytometry of CD64, HLA-DR, CD25, and TLRs for Diagnosis and Prognosis of Sepsis in Critically Ill Patients Admitted to the Intensive Care Unit: A Review Article

Establishment and validation of a prognostic model for hepatitis B virus‑related acute-on-chronic liver failure patients with bacterial infection

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