Pancreatic stone protein as a biomarker for the early diagnosis of post-operative peritonitis, intra-abdominal infection and sepsis

Ventura, François; Gasche, Yvan; Rached, Aymen Kraiem Ben; Pugin, Déborah; Mollard, Frédéric; Vora, Samir; Charbonnet, Pierre; Bühler, Léo H.

doi:10.1093/jscr/rjac497

Cited by 5 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the evolving definition of sepsis and the absence of a reference test, clinicians are often confused about how to clinically diagnose sepsis. For example, in Switzerland, more than half of clinicians (53.8%) pragmatically use a mixture of the various sepsis-associated scores (e.g., SIRS, MEWS, NEWS, qSOFA, SOFA) [18]. Moreover, when sepsis is suspected, a total of 89.7% measure circulating blood leucocytes; 92.3% use CRP; 84.6% measure PCT; and 100% measure lactate.…”

Section: Clinical Signs Scores and Biomarkersmentioning

confidence: 99%

“…We have previously proposed that a checklist should be established that outlines the basic requirements that sepsis biomarkers (infection, systemic inflammation response, and organ dysfunction) should meet [18]. Table 2 presents an updated and modified proposal of the ideal criteria for a sepsis biomarker for screening, diagnosing, and monitoring sepsis.…”

Section: Ideal Criteria For a Sepsis Biomarkermentioning

confidence: 99%

See 1 more Smart Citation

Proposed Framework for Conducting Clinically Relevant Translational Biomarker Research for the Diagnosis, Prognosis and Management of Sepsis

Ventura,

Greub,

Liles

et al. 2024

Diagnostics

View full text Add to dashboard Cite

Although the diagnosis of sepsis requires the identification of the three components of infection, a systemic inflammation response, and organ dysfunction, there is currently no consensus on gold-standard criteria. There are however suggested tools and tests, which have been proposed in international guidelines, including those produced by the Surviving Sepsis Campaign. Biomarkers play an important role in these tools and tests, and numerous heterogeneous studies have been performed to evaluate their respective clinical utility. Our review of the current practice shows that no biomarkers of infection, systemic inflammation response, organ dysfunction and sepsis are currently specifically recommended, which is probably due to the lack of standardization of studies. We therefore propose to define a framework for conducting clinically relevant translational biomarker research and seek to establish ideal criteria that can be applied to an infection, systemic inflammation response, organ dysfunction and sepsis biomarkers, which can enable early screening of sepsis, diagnosis of sepsis at the time of clinical suspicion and monitoring of sepsis treatment efficacy.

show abstract

Section: Clinical Signs Scores and Biomarkersmentioning

confidence: 99%

Section: Ideal Criteria For a Sepsis Biomarkermentioning

confidence: 99%

Proposed Framework for Conducting Clinically Relevant Translational Biomarker Research for the Diagnosis, Prognosis and Management of Sepsis

Ventura,

Greub,

Liles

et al. 2024

Diagnostics

View full text Add to dashboard Cite

show abstract

“…They can be used in the future diagnosis and follow-up of intra-abdominal sepsis. Markers, such as neutrophil CD64, 11 pancreatic stone protein, 48 5-hydroxyindoleacetic acid, 49 and Trefoil factor 3, 50 will better demonstrate their value in future studies. Since sepsis's pathogenesis is complex and accepted as a systemic disease, it is difficult to treat, and a standard treatment modality has not been determined yet.…”

Section: Other Less-used Current Markers and New Therapeutic Agents O...mentioning

confidence: 99%

A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review

Peksöz¹,

Agirman²,

Şentürk³

et al. 2023

Eurasian J Med

View full text Add to dashboard Cite

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection according to the Third International Consensus Definitions for Sepsis and Septic Shock definitions. It is a clinical condition with high morbidity and mortality due to its complex pathophysiology and lack of a complete treatment. It constitutes a significant economic burden because it constitutes a substantial part of intensive care patients, and the treatment process is lengthy and costly. Therefore, early diagnosis and treatment of the disease are essential. After pneumonia, an essential source of sepsis is intra-abdominal infection. Due to the presence of multiple and polymicrobial sources of infection, abdominal sepsis progresses more seriously. The effective treatment of intra-abdominal infection consists of early recognition of the disease, control of the source, appropriate antibiotic therapy, and stabilization in the intensive care setting with an excellent surgical approach. We searched PubMed, EMBASE, MEDLINE, and the Cochrane Library. Two authors reviewed all identified abstracts and selected articles for full-text review. We included original studies assessing mediators in intra-abdominal sepsis. Inflammatory and protein mediators such as acute phase protein and chemokine cytokines play an essential role in intra-abdominal sepsis. In clinical practice, white blood cell count, C-reactive protein, and procalcitonin are the most used parameters in the definition of abdominal infection. Tumor necrosis factor-alpha, interleukin-6, high-mobility group protein B1, and presepsin are other markers with high diagnostic efficiency, even though they are not used routinely. Despite everything, there is a need for highly effective markers that can be used in the diagnosis and follow-up of sepsis. Great hope is attached to these markers. This review aims to discuss the importance of the most used markers in the diagnosis and follow-up of abdominal sepsis and the markers on which there are essential studies in light of current literature.

show abstract

“…Searching for clinical studies of PSP and infection or sepsis in PubMed, we identified 1 prospective multicenter study, 29 20 prospective observational studies (Table 3 and 4), 2 meta-analyses, 30,31 2 literature reviews, 32,33 1 economic study, 34 2 technology study, 35,36 1 case report, 37 3 Covid-19 studies, [38][39][40] 1 book chapter, 41 2 point-of-view articles. 42,43 From the PubMed citations, we excluded 8 children studies, [44][45][46][47][48][49][50][51] 3 neonate studies, [52][53][54] 1 post-mortem study, 55 1 study in women for pregnancy-related disease, 56 1 PSP and diabetes study, 57 2 study protocols, 58,59 1 letter, 60 1 editorial, 61 4 comments, [62][63][64][65] and 1 published erratum. 66…”

Section: Pancreatic Stone Protein Clinical Studies For Infection and ...mentioning

confidence: 99%

Usefulness of pancreatic stone protein measurement to screen and diagnose sepsis in the context of the Surviving Sepsis Campaign recommendations.

Ventura,

Eggimann,

Daix

et al. 2023

MRAJ

View full text Add to dashboard Cite

Sepsis occurs yearly in 48.9 million people worldwide of whom 11 million will die. Sepsis is defined as a life-threatening dysregulated reaction of the body in response to a bacterial infection, leading to organ dysfunction. The Surviving Sepsis Campaign (SSC) made numerous recommendations for sepsis diagnosis and treatment using an evidence-based medicine approach. Frequently, levels of evidence of these recommendations are poor and lack clear clinical guidance. Interestingly, the SSC guidelines strongly recommend, with a moderate quality of evidence, screening of nosocomial sepsis in acutely ill hospitalized “high-risk patients”. The definition of acutely ill and high-risk patients is not specified, nor it is indicated which tools should be used. The diagnosis of infection and the subsequent administration of antibiotics relies solely on rapid clinical assessment, as recommended by the Best Practice Statement. Again, the elements used for clinical assessment are poorly defined, encompassing patient history, clinical examination, and tests for both infectious and non-infectious causes of acute illness. In the real world, only 30 to 40% of empiric broad-spectrum antibiotic administrations are appropriate, contributing to the emergence of antimicrobial resistant bacteria, toxicity related to antibiotic administration, and costs. The aim of this review article is to show that the use of biomarkers, such as the Pancreatic Stone Protein (PSP) as an example, helps in guiding the clinician to diagnose and manage sepsis. Over 600 peer-reviewed publications have studied the physiology of PSP and more than 50 evaluated its usefulness to screen for the development of nosocomial sepsis and diagnose sepsis.

show abstract

Pancreatic stone protein as a biomarker for the early diagnosis of post-operative peritonitis, intra-abdominal infection and sepsis

Cited by 5 publications

References 9 publications

Proposed Framework for Conducting Clinically Relevant Translational Biomarker Research for the Diagnosis, Prognosis and Management of Sepsis

Proposed Framework for Conducting Clinically Relevant Translational Biomarker Research for the Diagnosis, Prognosis and Management of Sepsis

A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review

Usefulness of pancreatic stone protein measurement to screen and diagnose sepsis in the context of the Surviving Sepsis Campaign recommendations.

Contact Info

Product

Resources

About