Pancreatic Stone Protein: Review of a New Biomarker in Sepsis

Fidalgo, Pedro; Nora, David; Coelho, Luís; Póvoa, Pedro

doi:10.3390/jcm11041085

Cited by 20 publications

(14 citation statements)

References 62 publications

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“…However, their values for identifying abdominal sepsis have yielded conflicting results [ 6 ]. A recent literature review [ 7 ] of 23 studies including a prospective multi-center study [ 4 ] and a meta-analysis [ 8 ] suggests that PSP has a higher diagnostic performance for the identification of infection and sepsis than the most used available biomarkers. The multi-center study shows that serial routine PSP measurement has the potential of ‘pre-symptomatic diagnosis of sepsis’ up to 72 h in advance with an optimal PSP cut-off of 290 ng/ml [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Pancreatic stone protein as a biomarker for the early diagnosis of post-operative peritonitis, intra-abdominal infection and sepsis

Ventura

Gasche

Rached

et al. 2022

Journal of Surgical Case Reports

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The diagnosis of intra-abdominal infection and post-operative peritonitis based on clinical examination, biomarkers and radiological signs, should be made as early as possible to improve outcomes and decrease mortality through early and optimal source control, adequate surgery and appropriate antibiotic therapy (Montravers et al. Therapeutic management of peritonitis: a comprehensive guide for intensivists. Intensive Care Med 2016;42:1234–47). However, the indication and the timing of the surgery is often not an easy decision. This case presents the use of a novel early biomarker of infection and sepsis, pancreatic stone protein (Fidalgo et al. Pancreatic stone protein: review of a new biomarker in sepsis. J Clin Med 2022;11:1085), as a tool to aid in the diagnosis of intra-abdominal infection and post-operative peritonitis and to help guide the decision for adequate surgeries in a patient with intra-abdominal infection and post radical prostatectomy peritonitis.

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Section: Discussionmentioning

confidence: 99%

Pancreatic stone protein as a biomarker for the early diagnosis of post-operative peritonitis, intra-abdominal infection and sepsis

Ventura

Gasche

Rached

et al. 2022

Journal of Surgical Case Reports

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“…is was consistent with our study. ere have been many research studies looking for markers for the diagnosis and treatment of sepsis, including microRNAs, long noncoding RNAs, circular RNAs, pancreatic stone protein, and lipopolysaccharide-binding protein [26][27][28][29][30]. In our research, we identified 15 major hub genes (CCL5, CCR7, CD2, CD27, CD274, CD3D, GNLY, GZMA, GZMH, GZMK, IL2RB, IL7R, ITK, KLRB1, and PRF1) in the PPI network, and all of them were downregulated genes in sepsis.…”

Section: Discussionmentioning

confidence: 99%

Screening of Sepsis Biomarkers Based on Bioinformatics Data Analysis

Liang

et al. 2022

Journal of Healthcare Engineering

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Background and objectives. Sepsis is a life-threatening organ dysfunction caused by the imbalance of the body’s response to infection. Delay in sepsis diagnosis has become a primary cause of patient death. This study aims to identify potential biomarkers of sepsis based on bioinformatics data analysis, so as to provide new gene biomarkers for the diagnosis and treatment of sepsis. Methods. Gene expression profiles of GSE13904, GSE26378, GSE26440, GSE65682, and GSE69528 were obtained from the National Center for Biotechnology Information (NCBI). The differentially expressed genes (DEGs) were searched using limma software package. Gene Ontology (GO) functional analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and protein-protein interaction (PPI) network analysis were performed to elucidate molecular mechanisms of DEGs and screen hub genes. Results. A total of 108 DEGs were identified in the study, of which 67 were upregulated and 41 were downregulated. 15 superlative diagnostic biomarkers (CCL5, CCR7, CD2, CD27, CD274, CD3D, GNLY, GZMA, GZMH, GZMK, IL2RB, IL7R, ITK, KLRB1, and PRF1) for sepsis were identified by bioinformatics analysis. Conclusion. 15 hub genes (CCL5, CCR7, CD2, CD27, CD274, CD3D, GNLY, GZMA, GZMH, GZMK, IL2RB, IL7R, ITK, KLRB1, and PRF1) have been elucidated in this study, and these biomarkers may be helpful in the diagnosis and therapy of patients with sepsis.

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“…PSP accuracy for the diagnosis of infection and sepsis among a wide spectrum of clinical settings seems to be, at least, comparable to the other classical biomarkers currently used in clinical practice. Furthermore, it seems to outperform those biomarkers in the prediction of sepsis, accounting for its earlier relative increase before clinical diagnosis, and it adds prognostic value [32,33]. PSP is a promising biomarker to diagnose infections in hospitalized patients.…”

Section: Discussionmentioning

confidence: 99%

Comparison of patients with community-acquired and hospital-acquired sepsis or septic shock: a systematic review and meta-analysis

Wang

Guo

et al. 2022

Preprint

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Background Mortality and other clinical outcomes between community-acquired and hospital-acquired patients with sepsis or septic shock have been documented inconsistently and are controversial. A systematic review and meta-analysis was performed to compare the clinical outcomes of community-acquired and hospital-acquired sepsis or septic shock. Methods We searched the PubMed, Embase databases and Cochrane Library for studies from inception to the 1st of Oct. 2022. We included studies involving patients with sepsis or septic shock. All authors reported our primary outcome of all-cause mortality and clearly comparing community-acquired versus hospital-acquired patients with clinically relevant secondary outcomes (ICU length of stay, hospital length of stay, mechanical ventilation requirements, renal replacement requirements, days on vasopressor and cost of hospitalization). Results were expressed as odds ratio (OR) and mean difference (MD) with accompanying 95% confidence interval (CI). Results Thirteen studies including 1175830 patients were included. The primary outcome of this meta-analysis showed that the all-cause mortality of hospital-acquired group was higher than that of the community-acquired group(OR = 0.43; 95% CI, 0.42 to 0.43; P < 0.00001; Chi2 = 262.95; I2 = 95%). Secondary outcomes demonstrated that the ICU length of stay of hospital-acquired group was longer than that of the community-acquired group(MD=-4.38;95% CI, -4.43 to -4.32; P < 0.00001;Chi2 = 2678.16; I2 = 100%), the hospital length of stay of hospital-acquired group was longer than that of the community-acquired group (MD=-12.36;95% CI, -12.44 to -12.27; P < 0.00001;Chi2 = 539.65; I2 = 98%), the mechanical ventilation requirements of hospital-acquired group was more than that of the community-acquired group (OR = 0.39; 95% CI, 0.32 to 0.46; P < 0.00001; Chi2 = 18.54; I2 = 84%), the days on vasopressor of hospital-acquired group was longer than that of the community-acquired group (MD=-1.71;95% CI, -1.78 to -164; P < 0.00001;Chi2 = 289.53; I2 = 100%), the cost of hospitalization of hospital-acquired group was more than that of the community-acquired group (MD=-34064.29; 95% CI, -34327.71 to -33800.87; P < 0.00001;Chi2 = 63.96; I2 = 98%). There was no statistically significant difference in the renal replacement requirements between two groups(OR = 0.75; 95% CI, 0.52 to 1.09; P = 0.13; Chi2 = 0.29; I2 = 0%). Conclusions The proportion of hospital-acquired sepsis or septic shock is about 12.9%. Compared with community-acquired sepsis or septic shock patients, hospital-acquired ones had higher mortality and other worse clinical outcomes, including longer ICU and hospital length of stay, more requirements of mechanical ventilation and renal replacement, longer vasopressor days and more cost of hospitalization.

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Pancreatic Stone Protein: Review of a New Biomarker in Sepsis

Cited by 20 publications

References 62 publications

Pancreatic stone protein as a biomarker for the early diagnosis of post-operative peritonitis, intra-abdominal infection and sepsis

Pancreatic stone protein as a biomarker for the early diagnosis of post-operative peritonitis, intra-abdominal infection and sepsis

Screening of Sepsis Biomarkers Based on Bioinformatics Data Analysis

Comparison of patients with community-acquired and hospital-acquired sepsis or septic shock: a systematic review and meta-analysis

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