Pancreatic tail schwannoma

Pecero-Hormigo, María del Carmen; Costo-Campoamor, Alberto; Cordero, Pedro-Luis Gonzalez; Fernandez‐Gonzalez, Nuria; Molina–Infante, Javier

doi:10.1016/j.gastrohep.2016.06.005

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…The majority of pancreatic schwannomas appear to be in the head and neck of the pancreas, but a small percentage may also be located in the tail of the pancreas [8]. Schwannoma may be mistaken for various benign and malignant pancreatic tumors [3].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Pancreatic Schwannoma

Tambovtseva¹,

Ashraf²,

Suleiman³

et al. 2022

Cureus

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Pancreatic schwannoma is a neuroendocrine cell tumor that arises in the pancreas. It is very rare, and, to date, only fewer than 70 similar cases have been reported in the literature. Here, we present another case of this type of tumor in a 68-year-old female.In addition to describing the pancreatic schwannoma, we discuss the major challenges associated with its diagnosis and management. As such, clinically and on imaging, pancreatic schwannomas are almost indistinguishable from other cancerous or benign pancreatic tumors. Therefore, only a biopsy can definitively diagnose pancreatic schwannomas by demonstrating spindle-shaped cells with immunohistochemistry positive for S-100.Because pancreatic schwannomas are very rare, it is important to increase awareness among clinicians about this condition and inform them regarding the challenges associated with its diagnosis and management.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Pancreatic Schwannoma

Tambovtseva¹,

Ashraf²,

Suleiman³

et al. 2022

Cureus

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“…Pancreatic schwannomas are well-demarcated, encapsulated, homogeneous, tan-yellow, round solid masses on macroscopical examination [1,3,28,29]. The classic features of pancreatic schwannomas often contain both hypercellular and hypocellular zones on microscopical examination [3,4,30].…”

Section: Discussionmentioning

confidence: 99%

MR imaging features of pancreatic schwannoma: a Chinese case series and a systematic review of 25 cases

et al. 2021

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Background There is a paucity of existing literature centering on the magnetic resonance (MR) imaging features of pancreatic schwannomas, due to the neoplasm’s nonspecific presentation and its rarity. We aimed to identify the characteristic imaging features of pancreatic schwannoma. Methods This retrospective search was conducted for histologically confirmed pancreatic schwannoma in multi-institutional database of pathology. Abdominal magnetic resonance imaging (MRI) was performed before histologic examination and their MR imaging studies were independently reviewed. The search yielded six adults (mean age, 46 years) with a definitive histologic postoperative diagnosis of single pancreatic schwannoma each. Additionally, a comprehensive English and Chinese literature review for pancreatic schwannoma and reported MR-imaging findings since 1961 was also conducted. MR imaging features of those cases in the literature were analyzed, summarized and compared with our case series. Results This rare entity appeared to be a well-circumscribed, exophytic, oval or round pancreatic mass with a mean greatest diameter of 3.7 cm. Five schwannomas were located in the pancreatic head-neck and one in the pancreatic tail. On MRI, all cases appeared hypointense on T1-weighted images, inhomogeneous hyperintense on T2-weighted images, and hyperintense on diffusion-weighted images. The mean apparent diffusion coefficient (ADC) values of pancreatic schwannoma were 1.11 ± 0.29 × 10− 3 mm2/s and significantly lower than the surrounding pancreas. The lesion-to-pancreas signal intensity ratio (SIR) at unenhanced T1-weighted images was 0.53 ± 0.07. On dynamic contrast-enhanced MRI, most of the lesions (67%, 4/6) showed homogeneously iso- or hypointense on arterial and portal venous phases, and hyperenhancement on delayed phase compared with the surrounding pancreas. In our analysis of the time intensity curves, all cases exhibited a gradual enhancement pattern. Conclusions A well-circumscribed mass displaying inhomogeneous hyperintensity on T2, marked hypointensity on T1, hyperintensity on DWI, and with early slight enhancement at arterial phase and progressive enhancement at portal venous and delayed phase, may suggest the diagnosis of pancreatic schwannoma.

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“…However, the type of nerve fibers that produce the origination of pancreatic schwannomas has not yet been described. To our knowledge, over the past 40 years, only 67 cases of pancreatic schwannoma have been reported in the English literature[ 8 - 68 ]. Table 1 summarizes the important available clinicopathological characteristics of these 68 cases, which include the present case.…”

Section: Discussionmentioning

confidence: 99%

“…Schwannomas in the pancreas are extremely rare. To our knowledge, over the past 40 years, only 67 cases have been reported in the English literature[ 8 - 68 ]. In the present study, we present a case of a pancreatic schwannoma that was successfully treated using a spleen-preserving distal pancreatectomy technique and performed a review of the available literature.…”

Section: Introductionmentioning

confidence: 99%

Successful treatment of a pancreatic schwannoma by spleen-preserving distal pancreatectomy

et al. 2017

WJG

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Schwannomas are neurogenic tumors that arise from the neural sheaths of peripheral nerves. These tumors can be located in any area of the human body; the most common locations are the head, neck, trunk and extremities. Pancreatic schwannomas are very rare. Over the past 40 years, only 67 cases of pancreatic schwannomas have been reported in the English literature. Here we present a case of pancreatic schwannoma in a 62-year-old male. The tumor was revealed by ultrasound and computed tomography in the neck and body of the pancreas. An accurate diagnosis was difficult to obtain preoperatively. The patient consented to the performance of a laparotomy, and the mass was found in the neck and body of the pancreas and successfully treated using a spleen-preserving distal pancreatectomy with splenic artery and vein preservation. The procedure has only been reported in one other case of pancreatic schwannoma; here we present the second reported case. Macroscopically, the tumor was well circumscribed, gray-white in color and 3.3 cm × 2.8 cm in size. Microscopically, the tumor cells were spindle-shaped and had a palisading arrangement with no atypia, which are results compatible with a benign tumor. Both hypercellular and hypocellular areas were visible. Immunohistochemically, the tumor cells were strongly positive for S-100 protein. The tumor was definitively diagnosed as a schwannoma of the pancreatic neck and body. The patient was followed for 72 mo and has been doing well without any complications.

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Pancreatic tail schwannoma

Cited by 5 publications

References 5 publications

A Rare Case of Pancreatic Schwannoma

A Rare Case of Pancreatic Schwannoma

MR imaging features of pancreatic schwannoma: a Chinese case series and a systematic review of 25 cases

Successful treatment of a pancreatic schwannoma by spleen-preserving distal pancreatectomy

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