Pancreatic tumors in childhood: Analysis of 13 cases

Grosfeld, Jay L.; Vane, Dennis W.; Rescorla, Frederick J.; McGuire, Warren A.; West, Karen W.

doi:10.1016/0022-3468(90)90218-x

Cited by 104 publications

(86 citation statements)

References 32 publications

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“…Cystadenomas (either serous or mucinous) have only been described in a handful of cases, whereas the majority of pancreatic cysts found in children were congenital lesions or developmental malformations, rather than true neoplasms [12,13]. In the present series, a 90-mm mucinous cystadenoma was resected, while deroofing was carried out for a 40-mm serous cystadenoma in order to avoid the high risk of a pancreaticoduodenectomy.…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Pancreatic Tumors in Childhood and Adolescence: Uncommon Neoplasms with Favorable Outcome

Marchegiani¹,

Crippa

Malleo³

et al. 2011

Pancreatology

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Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Pancreatic Tumors in Childhood and Adolescence: Uncommon Neoplasms with Favorable Outcome

Marchegiani¹,

Crippa

Malleo³

et al. 2011

Pancreatology

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“…Correspondingly, they offer a favourable postoperative prognosis as compared with other pancreatic malignancies. However, a pancreatoblastoma generally has to be classified as a malignant tumour because of the capability of metastatic spread in advanced stages, even following radical resections [11]. Nevertheless, the most striking difference between the two entities is given by their sex and age predilection; male:female ratio of approximately 2:1 and a median age of 4 years in pancreatoblastoma and nearly exclusively female sex and a median age of 21 years in the PSEN (table 1).…”

Section: Discussionmentioning

confidence: 99%

Pancreatoblastoma: Ultrastructural and Image DNA Cytometric Analysis

et al. 2001

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Background: Since the first description of a pancreatoblastoma as a malignant pancreatic tumour of childhood in 1957, approximately 60 cases have been reported. We present the symptoms, pathology, and therapy of this rare tumour in a 17-year-old girl. Case Report: The patient initially presented with upper gastro-intestinal bleeding. During laparotomy a 16-cm (diameter) tumour was recognized in the pancreatic tail. Open biopsy and radical resection, followed by histological and immunohistochemical examinations, confirmed the diagnosis of a pancreatoblastoma. The results of single-cell DNA cytometry underlined the low DNA grade of malignancy of the primary tumour. In spite of adjuvant chemotherapy with cisplatin and adriamycin, the patient returned 22 months later with many hepatic and peritoneal metastases measuring up to 5 cm in diameter. Peritoneal tumour debulking and an extended hemihepatectomy were performed as a palliative treatment. Unfortunately, the patient died 18 months later from further tumour progression. Conclusions: A review of the literature reveals that a pancreatoblastoma in childhood has to be considered malignant, but usually shows a favourable prognosis in contrast to pancreatic neoplasms in adult patients. The treatment of choice is radical resection. Adjuvant chemotherapy or radiotherapy should be considered because of the metastatic potential of the tumour.

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“…The patients' ages stood around 40 years, with 81% of patients aged less than 50 years. Most patients with this tumor were between 30 and 60, although there are reports of disease occurrence in the extremes of age 1,4 . Diagnosis can be difficult in some cases due to the predominance of neuropsychiatric symptoms that have multiple differential diagnoses.…”

Section: Discussionmentioning

confidence: 99%