Pancreatic β cell regeneration induced by clinical and preclinical agents

Pro-α-cell-derived β-cells contribute to β-cell neogenesis induced by antagonistic glucagon receptor antibody in type 2 diabetic mice

“…In this study, we showed that GCGR mAb also increased β-cell mass in T2D mice. There are several ways to increase β-cell mass, including the inhibition of β-cell apoptosis or dedifferentiation, promotion of β-cell proliferation, induction of α-to-β cell conversion, promotion of β-cell differentiation from pancreatic endocrine progenitors or stem cells ( Nair et al., 2020 ; Path et al., 2019 ; Wang et al., 2021a ; Wei and Hong, 2016 ). Here, we assessed the origins of increased β-cells induced by GCGR mAb in T2D mice and revealed a new approach to β-cell regeneration.…”

Evidence of Stem Cells Mobilization in the Blood of Patients with Pancreatitis: A Potential Link with Disease Severity

“…To the best of our knowledge, no data are available on the circulating levels of various populations of BMSCs in the PB of patients with pancreatic inflammatory disorders, and this phenomenon has not yet been examined in humans. Moreover, the issue of pancreatic regeneration is lively discussed in the scientific literature, with a focus on the endocrine pancreas and pancreatic islet regeneration and its meaning in the treatment of diabetes [18,22,[29][30][31][32][33][34]. Dor et al revealed that mature β-cells retain significant proliferative potential and their self-duplication capacity rather than SCs differentiation playing a major role in the process of β-cell replenishment [30].…”

Regeneration of β cells from cell phenotype conversion among the pancreatic endocrine cells

“…For instance, salsalate and resveratrol prevent β cell dedifferentiation in rodents and rhesus monkeys in vivo , and in primary human islets in vitro . 14 Moreover, mesenchymal stem cells and the stem cell‐derived particles (including exosomes or cytokines) can reverse β cell dedifferentiation. 15 , 16 However, continued intervention might be required to maintain the mature phenotype and avoid the progressive loss of β cells.…”