Pancreaticoduodenectomy for advanced gastric cancer with pancreaticoduodenal region involvement

Wang, Xinbao; Yang, Lei; Zhang, Zewei; Guo, Jianmin; Cheng, Xiangdong

doi:10.3748/wjg.14.3425

Cited by 22 publications

(32 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The number of patients known to have received adjuvant chemotherapy was 52. The chemotherapeutic regimens reported for adjuvant therapy were mitomycin C with 5-fluorouracil; etoposide, leucovorin, and 5-fluorouracil; and mitomycin C with tegafur [9,12,13]. Radiation therapy was not reported in any of the studies reviewed.…”

Section: Resultsmentioning

confidence: 99%

“…Six of the eight studies did not describe or report on staging investigations used prior to PD and gastrectomy [9][10][11][12][13]15]. Chan reported performing endoscopic ultrasound in 4 of 7 patients; pancreatic invasion was detected in one patient and was confirmed histologically [4].…”

Section: Resultsmentioning

confidence: 99%

“…Neoadjuvant chemotherapy was described in one study and this was used in four of 7 patients only [4]. Adjuvant chemotherapy was used in four of the eight studies, with one study not reporting the number of patients receiving adjuvant chemotherapy [4,9,12,13]. The number of patients known to have received adjuvant chemotherapy was 52.…”

Section: Resultsmentioning

confidence: 99%

“…The timing of the decision to perform a PD with gastrectomy was provided in 2 out of the 8 studies; in one study the decision to perform PD was described as based on pre-operative staging [14], while in another it was based on operative findings [4,[9][10][11][12][13]15]. The utilization of intra-operative frozen sections to determine margin status prior to embarking upon a PD was not noted.…”

Section: Resultsmentioning

confidence: 99%

“…Favorable results of PD for locally advanced gastric cancer have been reported in a few studies, but it remains a controversial procedure [4,[9][10][11][12][13][14][15]. The purpose of this study was to identify and synthesize short-and long-term outcomes from all articles on patients undergoing gastrectomy combined with PD for gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Systematic review of pancreaticoduodenectomy for locally advanced gastric cancer

et al. 2011

View full text Add to dashboard Cite

Background The purpose of this study was to identify and synthesize findings from all articles on surgical and longterm outcomes in patients with gastric cancer undergoing gastrectomy combined with pancreaticoduodenectomy (PD). Methods Electronic literature searches were conducted using Medline, EMBASE, and Cochrane databases from January 1, 1985, to December 31, 2009. Results Eight retrospective case series were included, with 132 patients having PD combined with gastrectomy. PD was combined with total gastrectomy in 27 patients, and subtotal gastrectomy in 81 patients; 24 patients had undocumented gastric resection type. Clinical stage was available for 92 patients (4 stage I, 7 stage II, 26 stage III, and 55 stage IV). Five studies (98 patients having PD combined with gastrectomy) compared PD and gastrectomy to gastrectomy alone. In the four studies reporting morbidity, PD had a higher morbidity. The pooled pancreatic anastomotic leak rate was 24.5% for the seven studies in which complications were reported; however, there were no peri-operative deaths. Long-term survival (37.3% at 5 years) in gastric cancer patients with PD combined with gastrectomy was described; however, survival was poor in the setting of incurable factors. Due to heterogeneity of patients and staging techniques in the case series no recommendations can be made on the appropriate selection criteria for patients undergoing PD and gastrectomy. Conclusion PD for gastric cancer invading the pancreas is associated with a higher morbidity; given the heterogeneous data, defining exact selection criteria is difficult.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Systematic review of pancreaticoduodenectomy for locally advanced gastric cancer

et al. 2011

View full text Add to dashboard Cite

show abstract

The importance of surgical margins in gastric cancer

Postlewait

Maithel

2015

Journal of Surgical Oncology

View full text Add to dashboard Cite

Interpretation and management of the surgical margin is paramount to the treatment of gastric adenocarcinoma. Although in early-stage disease, a microscopically positive margin may be associated with poor outcomes, in later stages, it does not persist as an independent poor prognostic factor but rather is likely a marker of other adverse pathologic characteristics that ultimately determine outcomes. Thus, the decision to extend a resection to achieve a negative margin should be deliberate and individualized.

show abstract