Pancytopenia in children: A 6-year spectrum of patients admitted to Pediatric Department of Rehman Medical Institute, Peshawar

A, Zeb Jan; Zahid, BasmaNabil; Ahmad, Samreen; Z, Gul

doi:10.12669/pjms.295.3865

Cited by 29 publications

(23 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pancytopenia is not a disease but a triad of findings that may result from a number of disease processes. These disorders may affect bone marrow either primarily or secondarily, resulting in the manifestation of pancytopenia [3]. Pancytopnia can result from damage to bone marrow evidenced by low reticulocyte count, or increased destruction of preformed blood cells peripherally with increased reticulocyte count [4].…”

mentioning

confidence: 99%

Detection of Pancytopenia Associated with Clinical Manifestation and Their Final Diagnosis

Azaad¹,

Li²,

Zhang³

et al. 2015

OJBD

View full text Add to dashboard Cite

mentioning

confidence: 99%

Detection of Pancytopenia Associated with Clinical Manifestation and Their Final Diagnosis

Azaad¹,

Li²,

Zhang³

et al. 2015

OJBD

View full text Add to dashboard Cite

“…Among those who had a neoplastic disorder, acute lymphoblastic leukaemia (ALL) (34%) was the most common. The BM findings in studies done among children in Pakistan, 14,15 Nepal, 16 Saudi Arabia 7 and US 17 were compared to the present study. The two studies from Pakistan showed that aplastic anaemia was the most common BM pathology among children whereas the studies from Nepal, 16 Saudi Arabia 7 and US 18 all showed that neoplastic disorders were the most common finding and acute leukaemias were the most predominant among the malignancies.…”

Section: Discussionmentioning

confidence: 79%

Untitled

2018

HTIJ

View full text Add to dashboard Cite

Background: Bone marrow examination is a key investigation for both haematological and non-haematological disorders where the bone marrow is involved. Bone marrow examination consists of bone marrow aspiration and bone marrow trephine biopsy which complement each other. Objectives:To describe the spectrum of pathologies found in the bone marrow of children below 18 years old at Kenyatta National Hospital and to determine the clinical features at presentation observed with the different pathologies found. Study design and site: This was a descriptive cross-sectional study carried out fromMethod: The registry at the Department of Human Pathology, University of Nairobi, was used to identify the eligible children who had a bone marrow aspirate/bone marrow trephine biopsy during the study period. The children were then traced back to their respective wards. The children were also recruited from the haematology clinic. Consent to use clinical data from their files and their bone marrow aspirate/bone marrow trephine biopsy reports were sought from parents/guardians and assent were obtained from minors aged 8 years and above. The information was collected using a structured questionnaire. The information was then analysed using SPSS software version 23.0.Results: A total of 90 patients' files and bone marrow examination reports were analysed. Ages of the patients ranged from 6 months to 18 years. The mean age of the children who participated in the study was 6.70±4.82 years. The peak age group for a bone marrow examination was 1 year to 5 years (43.3%). Males were 52 (57.8%) and females were 38 (42.2%). The main findings were neoplastic disorders (52.4%) followed by reactive marrow (28%) and nutritional anaemia (8.6%). Among the neoplastic disorders, acute lymphoblastic leukaemia (34%) was the most common. The commonest clinical presentations observed were pallor (51.2%), fever (32.5%), fatigue (27.5%) and bleeding manifestations (20%). Conclusion:The main bone marrow pathology found was neoplastic disorder, the majority of which were acute lymphoblastic leukaemia. The most common clinical manifestations found were pallor, fever, fatigue and bleeding manifestations.

show abstract

“…[8] MA is an important cause of pancytopenia occurring in critically ill patients [18] and should be promptly notified as it is rapidly correctable disorder. [12] Premkumar et al in his study mentioned that bone marrow examination has sensistivity of 90% in diagnosis of MA. [19] In study done by Kumar et al and Jha et al the most common cause of pancytopenia was hypoplastic marrow(33.33% and 29%) followed by MA (23.64%) and erythroid hyperplasia (27.08%).…”

Section: Annals Of Pathology and Laboratory Medicine Vol 6 Issue 1mentioning

confidence: 95%

“…[11] This finding was different from that of the study done exclusively in children by Jan et al with M:F ratio of 1.8:1. [12] This difference could be accounted for the large difference in the sample size in various studies. (Table 4) In present study, the most common age group to be affected was between 31-45 years (29cases, 37.66%) and next common age group to be affected was 16-30 years where 21 cases (27.28%) were seen.…”

Section: Annals Of Pathology and Laboratory Medicine Vol 6 Issue 1mentioning

confidence: 99%

Etio-Morphological Spectrum of Bone Marrow in Pancytopenia

Patil²,

Kittur³

2019

APALM

View full text Add to dashboard Cite

Etio-Morphological Spectrum of Bone Marrow in Pancytopenia Materials and Methods The present prospective study was undertaken during the period from November 2015 to April 2017 at Hematology Unit, Department of Pathology after obtaining approval from Institutional Ethics Committee. The study included 77 patients of all age groups and both the genders fulfilling the criteria of pancytopenia on initial workup i.e., Hemoglobin concentration (Hb%) below 10 g%, Total leukocyte count (WBC count) below 4 x 10 9 / L and Platelet count below 100 x 10 9 / L. [5] They were subjected to bone marrow aspiration (BMA) and/ or bone marrow biopsy (BMB) after obtaining the written consent. BMA smears were stained with Leishman's and Perl's routinely and with special stains like Periodic acid-Schiff and myeloperoxidase wherever required. Specimen obtained

show abstract

Pancytopenia in children: A 6-year spectrum of patients admitted to Pediatric Department of Rehman Medical Institute, Peshawar

Cited by 29 publications

References 9 publications

Detection of Pancytopenia Associated with Clinical Manifestation and Their Final Diagnosis

Detection of Pancytopenia Associated with Clinical Manifestation and Their Final Diagnosis

Untitled

Etio-Morphological Spectrum of Bone Marrow in Pancytopenia

Contact Info

Product

Resources

About