The lack of transparency at the beginning of the Covid-19 outbreak created misinformation in the public sphere. An infodemic is formed in the form of an abundance of information that makes it difficult for people to determine a valid source. The use of information technology with social media forms a significant role in influencing public behavior during the Covid-19 pandemic. The government also empowers information technology with social media as a public communication strategy. Accurate information is needed to identify the position of government social media in the Covid-19 infodemic. This study aims to obtain a comprehensive context from an open government perspective, namely transparency, participation, and collaboration so that the position of government social media and the Covid-19 infodemic can be identified so as to support a more optimal utilization strategy in handling the pandemic. This research uses a qualitative approach and collects various practices of using government social media in general and in the context of Covid19 in various countries as literature review material. The results of the literature study show that transparency is related to the optimal use of government social media, participation has relevance to public sentiment considering that participation has contributed to the development of the infodemic, while the scope of collaboration is a medium for grassroots interaction to encourage change for the better. The government is recommended to publish content quickly and accurately on platforms with high acceptance, utilize artificial intelligence, moderate toxic comments, and encourage participation towards collaboration between various parties.