Pandemic (H1N1) 2009 Virus and Down Syndrome Patients

Pérez‐Padilla, Rogelio; Fernández, R. Bermúdez-Cañete; García-Sancho, Cecilia; Franco‐Marina, Francisco; Aburto, Octavio; López‐Gatell, Hugo; Bojórquez, Ietza

doi:10.3201/eid1608.091931

Cited by 67 publications

(72 citation statements)

References 12 publications

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“…This can lead to severe respiratory syncytial virus bronchiolitis, a frequent cause of hospitalization in DS children (10,(26)(27)(28). Also, an increased risk of hospitalization, endotracheal intubation, and death due to influenza A virus infection was reported in DS (29). In addition, we found an increased proinflammatory cytokine response to live influenza A virus in children with DS, which might contribute to an increased severity of their clinical course of this infection (30).…”

mentioning

confidence: 61%

Increased production of interleukin-10 in children with Down syndrome upon ex vivo stimulation with Streptococcus pneumoniae

et al. 2013

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mentioning

confidence: 61%

Increased production of interleukin-10 in children with Down syndrome upon ex vivo stimulation with Streptococcus pneumoniae

et al. 2013

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“…We chose to consider these conditions because they represent a wide spectrum of chronic diseases in terms of morbidity, mortality and pattern of contacts with different health providers, and because they experience frequent complications during influenza [4-9]. Moreover the selected study population includes children affected with diseases that may be perceived with different levels of severity: this may affect the frequency of recommendations and immunization coverage.…”

Section: Methodsmentioning

confidence: 99%

“…HIV-infected children and adolescents, especially persons with a low CD4 cell count or AIDS, can experience more severe complications of seasonal influenza [8]. High rates of influenza-associated complications and death have been reported in children with Down syndrome [9]. …”

Section: Introductionmentioning

confidence: 99%

The effect of physician’s recommendation on seasonal influenza immunization in children with chronic diseases

et al. 2012

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BackgroundDespite recommendations by Health Authorities, influenza immunization coverage remains low in children with chronic diseases. Different medical providers involved in the management of children with chronic conditions may affect the pattern of influenza vaccine recommendations and coverage. The likelihood of vaccination by type of provider in children with chronic conditions is poorly understood. Therefore, the objectives of this study were to analyze the pattern and the effect of recommendations for seasonal influenza immunization provided by different physician profiles to families of children with chronic diseases and to measure the frequency of immunization in the study population.MethodsWe recruited children with chronic diseases aged 6 months–18 years who subsequently presented to specialty clinics for routine follow-up visits, during spring 2009, in three Italian Regions Families of children with chronic diseases were interviewed during routine visits at reference centers through a face-to-face interview. We analyzed the following immunization predictors: having received a recommendation toward influenza immunization by a health provider; child’s sex and age; mothers and fathers’ age; parental education and employment; underlying child’s disease; number of contacts with health providers in the previous year. Influenza immunization coverage was calculated as the proportion of children who received at least one dose of seasonal influenza vaccine in the previous season. We calculated prevalence ratios and we used a generalized linear model with Poisson family, log link and robust error variance to assess the effect of socio-demographic variables, underlying diseases, and recommendations provided by physicians on influenza immunization.ResultsWe enrolled 275 families of children with chronic diseases. Overall influenza coverage was 57.5%, with a low of 25% in children with neurological diseases and a high of 91.2% in those with cystic fibrosis. While 10.6% of children who did not receive any recommendation toward influenza immunization were immunized, among those who received a recommendation 87.5-94.7% did, depending on the health professional providing the recommendation. Receiving a recommendation by any provider is a strong predictor of immunization (PR = 8.5 95% CI 4.6;15.6) Most children received an immunization recommendation by a specialty (25.8%) or a family pediatrician (23.3%) and were immunized by a family pediatrician (58.7%) or a community vaccinator (55.2%).ConclusionsReceiving a specific recommendation by a physician is a strong determinant of being immunized against seasonal influenza in children with chronic diseases independently of other factors. Heterogeneity exists among children with different chronic diseases regarding influenza recommendation despite international guidelines. Increasing the frequency of appropriate recommendations toward influenza immunization by physicians is a single powerful intervention that may increase coverage in children with chronic conditions.

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“…This can lead to severe RSV bronchiolitis which in its turn is a frequent cause of hospitalization in DS children [7][8][9][10]. Very recently, it was shown that children with DS also have an increased risk of hospitalization, endotracheal intubation, and death due to influenza A virus infection [11].…”

Section: Introductionmentioning

confidence: 98%

Increased Pro-inflammatory Cytokine Production in Down syndrome Children Upon Stimulation with Live Influenza A Virus

et al. 2011

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Pandemic (H1N1) 2009 Virus and Down Syndrome Patients

Cited by 67 publications

References 12 publications

Increased production of interleukin-10 in children with Down syndrome upon ex vivo stimulation with Streptococcus pneumoniae

Increased production of interleukin-10 in children with Down syndrome upon ex vivo stimulation with Streptococcus pneumoniae

The effect of physician’s recommendation on seasonal influenza immunization in children with chronic diseases

Increased Pro-inflammatory Cytokine Production in Down syndrome Children Upon Stimulation with Live Influenza A Virus

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