Pandemic Influenza A/H1N1 Virus Infection in Solid Organ Transplant Recipients: A Multicenter Study

Smud, Astrid; Nagel, Claudia; Madsen, Elizabeth Leahy; Rial, María del Carmen; Barcán, Laura; Gomez, Abel A.; Martinoia, Andrea; Bangher, María C.; Altclas, Javier; Salgueira, Claudia; Temporiti, Elena; Bonvehí, Pablo; Enriquez, Natalia; Efrón, Ernesto; Bibolini, J.; Lattes, R.

doi:10.1097/tp.0b013e3181fc09fe

Cited by 39 publications

(40 citation statements)

References 21 publications

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“…16,17 Studies investigating the role of pH1N1/ 09 infection in transplant patients have been limited to retrospective and observational case series. 7,18,19 The range of symptoms is comparable to the symptoms of seasonal influenza (from a self-limiting upper respiratory disease to respiratory failure). Morbidity and mortality rates in this group of patients are substantial, and they have high rates of hospitalization and admission to intensive care.…”

Section: Discussionmentioning

confidence: 72%

“…Morbidity and mortality rates in this group of patients are substantial, and they have high rates of hospitalization and admission to intensive care. 7,17,[19][20][21] Infectionassociated episodes of cellular rejection have been described. 2,8,22 Therefore, vaccination against pH1N1/09 appears to be essential and is strongly recommended as part of the pretransplant workup and posttransplant care.…”

Section: Discussionmentioning

confidence: 99%

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Immune response to pandemic H1N1 2009 influenza a vaccination in pediatric liver transplant recipients

et al. 2011

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After the announcement of a worldwide pandemic in June 2009, a single dose of a monovalent pandemic H1N1 2009 influenza A (pH1N1/09) vaccine was advocated for all Australians who were 10 years and older because of excellent immunogenicity trial results for healthy children and adults. Immunocompromised patients have previously been shown to have lower seroconversion rates after routine vaccinations. There is a lack of data concerning the immune response of this patient group after pH1N1/09 vaccination. The aim of this study was to assess the immunogenicity of a pH1N1/09 vaccine in pediatric liver transplant recipients 10 years of age or older. Liver transplant recipients ! 10 years were prospectively recruited. All participants were administered a single intramuscular injection of the pH1N1/09 vaccine (15 lg). Serum antibody levels were determined by hemagglutination immediately before and ! 6 weeks after vaccination. Clinical and laboratory data (age, time since transplantation, immunosuppression, and lymphocyte counts) were analyzed comparing seroconverters and nonconverters with the Student's t test. A second dose of the vaccine was offered to all those who displayed no seroprotective titers after the first vaccination. Antibody levels were again determined 6 weeks later. Twenty-one of 28 liver transplant patients completed the study. The seroconversion rate was 62% after the first dose and 89.5% after the second dose. At baseline, 7 of 21 patients (33.4%) were already seropositive. Increasing time since transplantation positively correlated with successful seroconversion. In conclusion, a single dose of a pandemic influenza A vaccine does not elicit a reliable immune response in adolescent pediatric liver transplant patients. A second dose of the vaccine is warranted in this group of patients, at least in a pandemic scenario. There is an urgent need to further assess vaccine strategies in this highrisk group. Liver Transpl 17:914-920,

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Immune response to pandemic H1N1 2009 influenza a vaccination in pediatric liver transplant recipients

et al. 2011

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“…In kidney transplant recipients, H1N1 caused significant morbidity and mortality [95][96][97][98], and mortality is higher in transplant recipients compared to the general population [97]. More severe cases develop pneumonia and may require ICU admission and ventilator support.…”

Section: Less Common But Significant Viral Infections After Transplanmentioning

confidence: 99%

“…As seen in Table 3, a significant number of cancers are related to oncogenic viral infections. The Transplant Cancer Match Study assessed cancer risk in more than 175,000 solid organ transplant recipients, as compared to the general population [97]. It is important to note that this analysis includes only patients transplanted in the U.S., and the importance of biliary tract and bladder cancers due to parasitic infection outside of the U.S. are not represented in the analysis.…”

Section: Malignancymentioning

confidence: 99%

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Complications of Kidney Transplantation: Effects of Over-Immunosuppression

Aull¹,

Afaneh²,

Kapur³

2012

Current Concepts in Kidney Transplantation

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Corticosteroids as adjunctive therapy in the treatment of influenza

Lansbury

Rodrigo

Leonardi‐Bee

et al. 2019

Cochrane Database of Systematic Reviews

188

160

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Background Specific treatments for influenza are limited to neuraminidase inhibitors and adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions, most likely due to their anti-inflammatory and immunomodulatory properties. Although commonly prescribed for severe influenza, there is uncertainty over their potential benefits or harms. This is an update of a review first published in 2016. Objectives To systematically assess the e ectiveness and potential adverse e ects of corticosteroids as adjunctive therapy in the treatment of influenza, taking into account di erences in timing and doses of corticosteroids.

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Pandemic Influenza A/H1N1 Virus Infection in Solid Organ Transplant Recipients: A Multicenter Study

Abstract: Mortality is higher in Tx recipients than in the general population. Poor outcome seems to be related to a delay in the beginning of treatment.

Cited by 39 publications

References 21 publications

Immune response to pandemic H1N1 2009 influenza a vaccination in pediatric liver transplant recipients

Immune response to pandemic H1N1 2009 influenza a vaccination in pediatric liver transplant recipients

Complications of Kidney Transplantation: Effects of Over-Immunosuppression

Corticosteroids as adjunctive therapy in the treatment of influenza

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