2014
DOI: 10.1111/1469-0691.12646
|View full text |Cite
|
Sign up to set email alerts
|

Pandemic lineages of extraintestinal pathogenic Escherichia coli

Abstract: Pathogenic Escherichia coli strains cause a wide variety of intestinal and extraintestinal infections. The widespread geographical clonal dissemination of intestinal pathogenic E. coli strains, such as E. coli O157:H7, is well recognized, and its spread is most often attributed to contaminated food products. On the other hand, the clonal dissemination of extraintestinal pathogenic E. coli (ExPEC) strains is also recognized, but the mechanism of their spread is not well explained. Here, I describe major pandemi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

18
306
1
8

Year Published

2015
2015
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 353 publications
(333 citation statements)
references
References 114 publications
18
306
1
8
Order By: Relevance
“…The exact role of these virulence genes remains to be explained; however, it is possible that a combination of factors contributes to the fitness of ST131 rather than being directly involved in the pathogenesis of infection (79). In vivo studies suggest that fluoroquinolone-resistant E. coli isolates undergo compensatory mutations and become as fit as fluoroquinolone-susceptible isolates (46). This brings up some intriguing issues.…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…The exact role of these virulence genes remains to be explained; however, it is possible that a combination of factors contributes to the fitness of ST131 rather than being directly involved in the pathogenesis of infection (79). In vivo studies suggest that fluoroquinolone-resistant E. coli isolates undergo compensatory mutations and become as fit as fluoroquinolone-susceptible isolates (46). This brings up some intriguing issues.…”
Section: Resultsmentioning
confidence: 99%
“…The term clone has also become useful in molecular epidemiology, particularly in the study of possible relationships between isolates from different geographical areas. It has become well recognized that not all isolates of pathogenic species are necessarily equal and that in a typical pathogenic species, a small number of clones, clusters, or lineages are greatly overrepresented among those isolates recovered from particular types of infection (46).…”
Section: International Multidrug-resistant High-risk Clonal Lineagesmentioning
confidence: 99%
See 1 more Smart Citation
“…Sensitivities reported for the detection of resistance to fluoroquinolones (75%) and trimethoprim-sulfamethoxazole (74%) are not adequate for clinical use, but this study may serve as a starting point for the development of rapid molecular testing for this application (33). ST131 has disseminated globally and is responsible for much of the increase in antimicrobial-resistant extraintestinal E. coli infections (34). Fluoroquinolone resistance in E. coli, including ST131, is most commonly mediated by mutations in the quinolone resistance-determining region (QRDR) of genes encoding DNA gyrase and topoisomerase IV, gyrA and parC.…”
Section: Molecular Screeningmentioning
confidence: 96%
“…The molecular testing presented, and this approach in general, suffers from several limitations when utilized as an indirect test of fluoroquinolone resistance. This method would fail to detect organisms other than E. coli or those belonging to a different clonal group than the most common, which may be particularly important in geographic regions in which different fluoroquinolone-resistant clones are found (34). Additionally, resistance mediated by the less common mechanisms described, and not associated with a particular clonal group, would not be detected.…”
Section: Molecular Screeningmentioning
confidence: 99%