Pandrug-Resistant<i>Acinetobacter baumannii</i>Causing Nosocomial Infections in a University Hospital, Taiwan

Hsueh, Po‐Ren; Teng, Lee-Jene; Chen, Cheng-Yi; Chen, Wen-Hwei; Ho, Shen‐Wu; Luh, Kwen‐Tay

doi:10.3201/eid0805.020014

Cited by 190 publications

(136 citation statements)

References 25 publications

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“…The most common bacteria isolated by Behzadnia et al (13) from the burn wound were also P. aeruginosa and Acinetobacter species. Similar results were found in other studies and the results of our review (26)(27)(28). Behzadnia et al (13) also found underlying diseases including diabetes mellitus and use of steroids, as established risk factors for NIs, among pediatric patients with burn injuries.…”

Section: Discussionsupporting

confidence: 79%

Nosocomial Infections in Iranian Pediatric Patients With Burn Injuries: A Review

Rezai¹,

Shahmohammadi²

2015

J Pediatr Rev

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Section: Discussionsupporting

confidence: 79%

Nosocomial Infections in Iranian Pediatric Patients With Burn Injuries: A Review

Rezai¹,

Shahmohammadi²

2015

J Pediatr Rev

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“…As reported in a Taiwanese study, the emergence of XDR or pandrug-resistant A. baumannii strains is associated with increasing use of carbapenems and ciprofloxacin. 14 All of the A. baumannii strains in our study were resistant to carbapenems, aminoglycosides, quinolones and cephalosporins. Resistance to CO was not detected.…”

Section: Discussionmentioning

confidence: 77%

In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii

et al. 2009

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The emergence of extensive drug-resistant (XDR) Acinetobacter baumannii limits the therapeutic options and leads to high mortality in intensive care units. Combined antibiotic therapy is frequently recommended for the treatment of these infections. Colistin (CO) and tigecycline (TIG), alone or in combination with other antimicrobials, are the most commonly used antibiotics in the treatment of these resistant infections. In this study, the in vitro synergistic activity of TIG and CO were tested for 25 XDR-A. baumannii strains isolated from ventilator-associated pneumonia by the Etest method. Resistance to CO was not detected, whereas 8% of the strains were resistant to TIG. The TIG-CO combination was more synergistic than TIG-rifampin and CO-rifampin according to the fractional inhibitory concentration index. No antagonism was detected between the drugs in the study. There was no strong correlation between the activity of the combinations with reference to strains or genotypes. Our results suggest that the combined use of TIG and CO may be useful for the treatment of XDR-A. baumannii infections.

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“…One of the main reasons is that clinical isolates are frequently resistant to many commonly used antimicrobial agents (multidrug resistant -MDR) [10,33]. Often are susceptible only to carbapenems (imipenem, meropenem), though resistant strains are increasingly reported, and amikacin, polymyxins, but some may be susceptible only to polymyxins [29,35,40,43,56,57,74,106,129,136]. Colonization of the digestive tract intensive care unit patients is an important epidemiologic reservoir for multi-drug resistant Acinetobacter baumannii infections in hospital outbreaks [22].…”

Section: Introduction -Acinetobacter Baumanniimentioning

confidence: 99%

Multidrug resistant Acinetobacter baumannii--the role of AdeABC (RND family) efflux pump in resistance to antibiotics.

Wieczorek

Sacha²,

Hauschild³

et al. 2008

Folia Histochem Cytobiol.

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Abstract:Acinetobacter baumannii is an opportunistic pathogen which play the more and more greater role in the pathogenicity of the human. It is often attached with the hospital environment, in which is able easily to survive for many days even in adverse conditions. Acinetobacter baumannii is the species responsible for a serious nosocomial infections, especially in the intensive care units. Option of surviving in natural niches, and in the hospital environment could also be associated with the efflux pump mechanisms. Mechanisms of efflux universally appear in all cells (eukaryotic and prokaryotic) and play the physiological important role. In prokaryote, the main functions are evasion of such naturally produced molecules, removal of metabolic products and toxins. These pumps could also be involved in an early stage of infection, such as adhesion to host cells and the colonization. Importantly, they remove commonly used antibiotics from the cell in therapy of infections caused by these bacteria. Efflux pumps exemplify a unique phenomenon in drug resistance: a single mechanism causing resistance against several different classes of antibiotics. In Acinetobacter baumannii, the AdeABC efflux pump, a member of the resistance-nodulation-cell division family (RND), has been well characterized. Aminoglicosides, tetracyclines, erythromycin, chloramphenicol, trimethoprim, fluoroquinolones, some β-lactams, and also recently tigecycline, were found to be substrates for this pump. Drugs, as substrates for the AdeABC pump, can increase the expression of the AdeABC genes, leading to multidrug resistance (MDR). From this reason, treatment failure and death caused by Acinetobacter baumannii infections or underlying diseases are common. Because the AdeABC pump is widespread in Acinetobacter baumannii, similarly to other pumps in Gram-negative and Gram-positive bacteria, exists a need of searching a new therapeutic solutions. Specific efflux inhibitors of pumps (EPIs), including AdeABC inhibitors, could be suppress the activity of pumps and restore the sensitivity of such important bacteria as Acinetobacter baumannii to commonly used antibiotic.

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Pandrug-ResistantAcinetobacter baumanniiCausing Nosocomial Infections in a University Hospital, Taiwan

Cited by 190 publications

References 25 publications

Nosocomial Infections in Iranian Pediatric Patients With Burn Injuries: A Review

Nosocomial Infections in Iranian Pediatric Patients With Burn Injuries: A Review

In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii

Multidrug resistant Acinetobacter baumannii--the role of AdeABC (RND family) efflux pump in resistance to antibiotics.

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