Paniand#8217;s Filariasis

Pani, Sankarsan

doi:10.5005/jp/books/12148

Cited by 2 publications

(2 citation statements)

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“…Currently, tools for constructing probabilistic SV genotypes from longreads harnessing genome graphs are lacking. We incorporated such functionality as the fifth and final step into the SAGA framework, by devising Giggles 42 , a genotyping tool that harnesses graph-aligned ONT reads for SV genotyping. We applied Giggles (version: 1.0) to the set of 967 samples of HPRC_mg_44+966 for which our study generated ONT data, yielding a multi-sample VCF comprising genotypes for 167,291 primary SV sites after filtering (Methods).…”

Section: Construction Of Pseudo-haplotypes and Graph-augmentationmentioning

confidence: 99%

Long-read sequencing and structural variant characterization in 1,019 samples from the 1000 Genomes Project

Schloissnig,

Pani,

Rodriguez-Martin

et al. 2024

Preprint

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Structural variants (SVs) contribute significantly to human genetic diversity and disease. Previously, SVs have remained incompletely resolved by population genomics, with short-read sequencing facing limitations in capturing the whole spectrum of SVs at nucleotide resolution. Here we leveraged nanopore sequencing to construct an intermediate coverage resource of 1,019 long-read genomes sampled within 26 human populations from the 1000 Genomes Project. By integrating linear and graph-based approaches for SV analysis via pangenome graph-augmentation, we uncover 167,291 sequence-resolved SVs in these samples, considerably advancing SV characterization compared to population-wide short-read sequencing studies. Our analysis details diverse SV classes-deletions, duplications, insertions, and inversions-at population-scale. LINE-1 and SVA retrotransposition activities frequently mediate transductions of unique sequences, with both mobile element classes transducing sequences at either the 3′- or 5′-end, depending on the source element locus. Furthermore, analyses of SV breakpoint junctions suggest a continuum of homology-mediated rearrangement processes are integral to SV formation, and highlight evidence for SV recurrence involving repeat sequences. Our open-access dataset underscores the transformative impact of long-read sequencing in advancing the characterisation of polymorphic genomic architectures, and provides a resource for guiding variant prioritisation in future long-read sequencing-based disease studies.

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Section: Construction Of Pseudo-haplotypes and Graph-augmentationmentioning

confidence: 99%

Long-read sequencing and structural variant characterization in 1,019 samples from the 1000 Genomes Project

Schloissnig,

Pani,

Rodriguez-Martin

et al. 2024

Preprint

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“…Additionally, there is an increase in lymphatic drainage during exercise based on that decreased intrathoracic pressure during inhalation can cause lymphatic flow, and exercise can stimulate the respiratory system [58]. Furthermore, deep lymphatic vessels have a preference of flowing the pathways of arteries [59], and the constant pulsation of arteries presses lymphatic vessels and helps lymphatic flow [60]. Exercise stimulates the cardiovascular system leading to higher pulse pressure in the arteries [61], providing a stronger driving force for lymphatic drainage.…”

Section: Water-based Exercisementioning

confidence: 99%

The effect of exercise on breast cancer-related lymphedema

Yanxue

Sandhu

Yamikani

et al. 2023

Preprint

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Purpose: This review will provide an overview of the current state of knowledge by 1) evaluating the feasibility and safety of exercise as a treatment for patients with breast cancer-related lymphedema (BCRL), and 2) exploring the effects of different exercises on patients with BCRL. Method: A systematic literature review of relevant studies published before 30 June 2022 was performed using three scientific databases PubMed, Embase, and Scopus. Result: A total of 611 articles were found. Eventually, 15 articles fulfilled the inclusion criteria and were used for this literature review. A total of 5 different exercises, consisting of yoga, Pilates, resistance exercise, aquatic-based exercise, and complex exercise of aerobic and resistance training are included. Conclusion: The review shows that these exercises are safe for patients with BCRL. Some measurable effects of exercises on lymphedema and some possible reasons/theories are shown. Implications for Cancer Survivors: Although only yoga, Pilates, and resistance exercise may improve the severity of lymphedema based on the measurement of limb volume, all 5 exercise modes can help improve lymphedema symptoms to some extent. The improvement of symptoms may cause the increased quality of life (QoL) in symptom and physical functioning domains, leading to increased emotional and social function.

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Paniand#8217;s Filariasis

Cited by 2 publications

References 0 publications

Long-read sequencing and structural variant characterization in 1,019 samples from the 1000 Genomes Project

Long-read sequencing and structural variant characterization in 1,019 samples from the 1000 Genomes Project

The effect of exercise on breast cancer-related lymphedema

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