Panniculitis associated with pancreatitis in a cocker spaniel

Mellanby, Richard J.; Stell, Anneliese; Baines, Elizabeth; Chantrey, Julian; Herrtage, M. E.

doi:10.1111/j.1748-5827.2003.tb00100.x

Cited by 30 publications

(31 citation statements)

References 12 publications

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“…Predilection sites are trunk neck and proximal extremities, lymphadenopathy is uncommon and there are usually systemic signs such as pyrexia, anorexia, lethargy and depression (Torres 1999, Scott and others 2001). Panniculitis associated with pancreatitis with intra-abdominal fat involvement have also been reported (Scott and others 2001, Mellanby and others 2003, Gross 2005). In the dog described herein, no cutaneous lesions and no evidence of pancreatitis were found; therefore, sterile nodular panniculitis as the cause of the clinical signs of this dog was unlikely.…”

Section: Discussionmentioning

confidence: 98%

Idiopathic sterile pyogranulomatous lymphadenitis in a nine‐month‐old springer spaniel

Fraga-Manteiga

Veloso

Schwarz

2016

Vet Record Case Reports

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A nine-month-old, intact male springer spaniel was presented with acute mandibular lymphadenopathy seven days following exploratory coeliotomy and biopsy of an enlarged mesenteric lymph node. Histology was consistent with sterile severe necrotising pyogranulomatous inflammation. An underlying cause of the granulomatous lymphadenitis could not be identified. The dog responded to prednisolone, showing complete resolution of the clinical signs. This could be an unusual presentation of canine juvenile cellulitis, without a cutaneous component and without initial submandibular or prescapular lymphadenopathy.

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Section: Discussionmentioning

confidence: 98%

Idiopathic sterile pyogranulomatous lymphadenitis in a nine‐month‐old springer spaniel

Fraga-Manteiga

Veloso

Schwarz

2016

Vet Record Case Reports

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“…Based on reports in dogs as well as in humans, we postulate that in at least 5 of these cases SNP may have had a direct association with a concurrent disease process (pancreatic disease, rheumatoid arthritis, SLE, and possibly lymphoplasmacytic colitis). Pancreatic disease, including pancreatitis, pancreatic neoplasia, and pancreatic nodular hyperplasia, has been reported in association with panniculitis in dogs 6–10 . The mechanism by which pancreatic disease induces panniculitis currently is unclear.…”

Section: Discussionmentioning

confidence: 99%

“…SNP is an idiopathic disorder 1,3–5 that is either primary in origin or associated with a variety of other illnesses, including pancreatic nodular hyperplasia, 6 pancreatic neoplasia, 7–9 pancreatitis, 10 and immunologic diseases such as rheumatoid arthritis 11 and systemic lupus erythematosus (SLE) 3 . Concurrent inflammation of fat in the abdomen, 12 epidural space, 13 and bone 7 can occur in dogs with SNP, as can other inflammatory conditions such as polyarthritis 7 .…”

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confidence: 99%

Canine Sterile Nodular Panniculitis: A Retrospective Study of 14 Cases

O'Kell¹,

Inteeworn²,

Diaz³

et al. 2010

Journal of Veterinary Internal Medicine

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Background: Sterile nodular panniculitis (SNP) is an uncommon inflammatory condition of subcutaneous fat that can be idiopathic, but has also been associated with underlying conditions such as pancreatic disease or systemic lupus erythematosus (SLE). The pathogenesis and clinical course of the condition are not well understood.Objectives: To retrospectively review cases of SNP associated with systemic signs, concurrent disease, or both and characterize the clinical, laboratory, imaging, and histopathologic findings, treatment, and response to treatment.Animals: Fourteen dogs with histologically confirmed SNP diagnosed between 1996 and 2008. Methods: Retrospective study.Results: Skin lesions were ulcerated or draining nodules in 9 dogs and nonulcerative subcutaneous nodules in 5. Most dogs had systemic signs, such as fever, inappetence, lethargy, and multiple lesions. Common clinicopathologic findings included neutrophilia with or without left shift, increased alkaline phosphatase activity, mild hypoglycemia, hypoalbuminemia, and proteinuria. Concurrent diseases included pancreatic disease, SLE, rheumatoid arthritis, polyarthritis, lymphoplasmacytic colitis, and hepatic disease. Dogs responded to immunosuppressive doses of corticosteroids when administered. Prognosis for recovery was related to the underlying disease process.Conclusions and Clinical Importance: SNP is not a single disease. Rather, it is a cutaneous marker of systemic disease in many cases. After thorough evaluation for concurrent disease and infectious causes, immunosuppressive treatment is often effective.

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“…In mammalian species, pancreatitis may occasionally induce changes in distant adipose tissues. 24 Histologic evaluation of the pancreas was not done in this bird. However, pancreatic changes sufficient to precipitate fat necrosis are generally grossly apparent, and the pancreas in this bird appeared grossly normal at necropsy.…”

Section: Discussionmentioning

confidence: 99%

Coelomic Granulomatous Fat Necrosis (Lipogranulomatosis) in an Umbrella Cockatoo (Cacatua alba)

Oglesbee¹,

Lightner²,

Oglesbee³

2014

Journal of Avian Medicine and Surgery

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A 28-year-old, female umbrella cockatoo (Cacatua alba) was evaluated because of lethargy, anorexia, regurgitation, and coelomic swelling of 6 month's duration, which corresponded to cessation of egg laying. Radiographs and ultrasound examination demonstrated extensive deposits of coelomic fat and an enlarged oviduct. Exploratory celiotomy demonstrated copious amounts of firm, nodular fat completely surrounding the gastrointestinal tract, resulting in extensive chronic adhesions between intestinal loops. Free yolk was present in the cranial left coelom, yolk coelomitis was diagnosed, and a salpingohysterectomy was performed. Two days after surgery, the bird stopped passing feces and began regurgitating after eating, and a colonic obstruction was demonstrated via contrast radiography. Euthanasia was elected, and necropsy revealed an obstruction of the distal colon caused by extraluminal compression by adhesions of firm, nodular fat. Histologic examination demonstrated extensive fat necrosis with granulomatous inflammation, characterized by cords of necrotic fat surrounded by multinucleated giant cells and epithelioid macrophages with scattered lymphocytes and plasma cells and rare heterophils. The clinical signs, gross lesions, and histologic lesions are characteristic of massive fat necrosis (lipogranulomatosis) in ruminants and mesenteric panniculitis in humans and companion mammals. This is the first report, to our knowledge, of this disease in psittacine birds.

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Panniculitis associated with pancreatitis in a cocker spaniel

Cited by 30 publications

References 12 publications

Idiopathic sterile pyogranulomatous lymphadenitis in a nine‐month‐old springer spaniel

Idiopathic sterile pyogranulomatous lymphadenitis in a nine‐month‐old springer spaniel

Canine Sterile Nodular Panniculitis: A Retrospective Study of 14 Cases

Coelomic Granulomatous Fat Necrosis (Lipogranulomatosis) in an Umbrella Cockatoo (Cacatua alba)

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