Pantoprazole for the Treatment of Peptic Ulcer Bleeding and Prevention of Rebleeding

Rensburg, C. J. Van; Cheer, Susan M.

doi:10.4137/cgast.s9893

Cited by 10 publications

(10 citation statements)

References 75 publications

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“…[ 25 26 ] Recent consensus on the amounts of intravenous pantoprazole in patients with gastric bleeding under successful endoscopic therapy showed that consumption of intravenous pantoprazole along with its continuous injection is effective for reducing bleeding. [ 29 ] In this regard, van Rensburg and Cheer stated that the amount of intravenous pantoprazole in patients with peptic ulcers that are not able to have oral therapy is recommended as 40 mg daily injection,[ 29 ] that is in conflict with the current study, as in this study it was found no difference between the two methods.…”

Section: Discussioncontrasting

confidence: 60%

“…In this regard, the findings of many studies suggest that suitable doses of pantoprazole are not necessarily high. [ 3 29 ] Based on our findings, intravenous administration of pantoprazole (in both ways) has positive impact on GI bleeding. Lau et al .…”

Section: Discussionmentioning

confidence: 74%

“…[ 21 ] Furthermore, the recommended intravenous pantoprazole in patients who are not able to have oral therapy is 40 mg daily injection. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

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Efficacy Comparison of Divided and Infusion Intravenous Pantoprazole Methods after Endoscopic Therapy in Patients with Acute Gastrointestinal Bleeding

Motiei

Sebghatolahi

2017

Adv Biomed Res

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Background:Intravenous pantoprazole administration in patients with severe bleeding under urgent endoscopic therapy is effective. Furthermore, its infusion dose is useful to control bleeding; however, it is not economical. In this study, clinical outcomes and intravenous infusion of pantoprazole after endoscopic therapy plus efficacy of infusion dosage and divided doses are compared.Materials and Methods:This prospective, comparative study conducted on 18 adult (>18 years) patients referred to Al Zahra Hospital for hematemesis and melena bleeding who underwent endoscopic treatment with pantoprazole which divided into two groups of forty patients. First group received intravenous infusion for 80 mg and 8 mg/h. The second group received intravenous infusion with divided doses as 40 mg twice daily for 3 days. Clinical outcomes such as rebleeding, duration of hospitalization, amount of blood transfused, and mortality within 3 days after endoscopic treatment were collected and analyzed by SPSS software (version 20) using independent t-test, Chi-square test, and Fisher's exact test.Results:Duration of hospitalization in the pantoprazole infusion group was 5.42 ± 4.62 days, with three patients (7.5%) having rebleeding, and in the divided pantoprazole group was 5.90 ± 3.08 days, with four patients (10%) having rebleeding, and overall, only one person died in the divided pantoprazole group (2.5%) out of eighty patients. No significant difference was observed between two groups in terms of clinical outcomes (P > 0.05).Conclusion:Regarding to results, it can be stated that both methods with specified dosage had significant impact on improvement of hematemesis and melena. Furthermore, due to lower costs, low dose of pantoprazole in divided approach as 40 mg/12 h is proposed.

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 74%

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Efficacy Comparison of Divided and Infusion Intravenous Pantoprazole Methods after Endoscopic Therapy in Patients with Acute Gastrointestinal Bleeding

Motiei

Sebghatolahi

2017

Adv Biomed Res

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“…More aggressive pH goals have been established to promote hemostasis and healing of bleeding peptic ulcers. 31 , 32 Thus, acid-suppressant therapy is recommended for the treatment of people with acid-related disorders and, in particular, patients with peptic ulcers. 28 Ideal intragastric conditions for hemostasis in cats might be similar to those of people; however, it is unknown whether therapeutic goals established for people can be extrapolated to other species.…”

Section: Discussionmentioning

confidence: 99%

Medical management of gastrinoma in a cat

Lane

Larson

Hecht

et al. 2016

Journal of Feline Medicine and Surgery Open Reports

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Case summaryA 7-year-old male castrated domestic short-haired cat was evaluated for a 4 week history of intermittent vomiting, ptyalism, lethargy and weight loss. Serum biochemistry revealed mild mixed hepatopathy. Abdominal ultrasonography identified multiple heterogeneous hepatic masses and a linear, hyperechoic focus with associated reverberation artifact in the wall of the stomach consistent with a gastric ulcer. Serum gastrin concentrations were markedly increased. Cytologic interpretation of a fine-needle aspirate of the hepatic masses was consistent with neuroendocrine neoplasia, and a diagnosis of gastrinoma was established. Deterioration of the cat’s condition, despite at-home acid-suppressant therapy, led to hospitalization. The cat was initially stabilized with intravenous crystalloid fluid therapy, maropitant, pantoprazole and octreotide. A continuous radiotelemetric intragastric pH monitoring system was used to monitor the response of intragastric pH to therapy. Long-term therapy was continued with omeprazole (orally q12h), octreotide (subcutaneously q8h) and thrice-weekly toceranib administered orally. Toceranib therapy led to gastrointestinal upset and was discontinued. Gastric ulceration resolved within 8 weeks, and palliation of clinical signs was achieved for approximately 5 months.Relevance and novel informationIncluding this report, only six cases of feline gastrinoma have been reported in the veterinary literature. Little is known regarding non-surgical therapy, and octreotide has not been previously reported for medical management of feline gastrinoma. Results of intragastric pH monitoring and clinical improvement suggest that medical therapy using octreotide and proton pump inhibitors represents a novel therapeutic option for cats with gastrinoma where surgical excision is not feasible.

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“…The adoption and inclusion of these elements have contributed to the overall improvement in successful management of NVUGIB. For instance, early institution of PPIs at the time of index presentation has effectively diminished the risk of re-bleeding, whereas the use of evidence-based approach in selecting hemostatic methods has increased the success rate of endoscopic intervention [4,5].…”

Section: Introductionmentioning

confidence: 99%

Endoscopic Hemostasis for Non-Variceal Upper Gastrointestinal Bleeding: New Frontiers

Kichler

Jang

2019

Clin Endosc

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Non-variceal upper gastrointestinal bleeding (NVUGIB) refers to blood loss from the gastrointestinal tract proximal to the ligament of Treitz due to lesions that are non-variceal in origin. The distinction of the bleeding source as non-variceal is important in numerous aspects, but none more so than endoscopic approaches for successful hemostasis. When a patient presents with acute overt blood loss, NVUGIB is a medical emergency, which requires immediate intervention. There have been major strides in pharmacologic and endoscopic interventions for successful induction and remission of hemostasis in the last two decades. Despite achieving tangible improvements, the burden of the disease and the consequent mortality remain high. To address endoscopic outcomes better, several new technologies have emerged and have been subsequently incorporated to the armamentarium of hemostatic tools. This study aims to provide a succinct review on novel technologies for endoscopic hemostasis.

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Pantoprazole for the Treatment of Peptic Ulcer Bleeding and Prevention of Rebleeding

Cited by 10 publications

References 75 publications

Efficacy Comparison of Divided and Infusion Intravenous Pantoprazole Methods after Endoscopic Therapy in Patients with Acute Gastrointestinal Bleeding

Efficacy Comparison of Divided and Infusion Intravenous Pantoprazole Methods after Endoscopic Therapy in Patients with Acute Gastrointestinal Bleeding

Medical management of gastrinoma in a cat

Endoscopic Hemostasis for Non-Variceal Upper Gastrointestinal Bleeding: New Frontiers

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