Papaya leaf (Carica papaya L.) ethanol extract to the histopathological description of the testimony in in the house mouse (Mus Musculus)

Abstract

The development of contraceptive methods is more focused on female contraception than men is still lacking. Papaya leaves are thought to have an antifertility effect due to the content of secondary metabolites, namely flavonoids, alkaloids, saponins, tannins and papain enzymes that have estrogenic effects that can disrupt hormone regulation in the hypothalamic-pituitary-gonadal axis. This study aimed to prove the administration of ethanol extract of papaya leaves (Carica papaya L.) on the histopathological features of the testicles of young adult mice (Mus musculus). Subjects and Method: This research uses an experimental study with a post-test only control group design. The samples used were male Swiss Webster strain mice (Mus musculus) 2-3 months old with a bodyweight of 20-30 grams as many as 36 individuals were divided into 2 groups. The control group (P0) was given 0.5 ml of Tween 3% and the treatment group (P1) was given ethanol extract of Papaya Leaf (Carica papaya L.) 0.21 mg/gram BW as much as 0.5 ml for 36 days orally. The data obtained were analyzed using the Independent Sample T-test. Result: A total of 11 articles from Asia continent (India, Bangladesh, Philipina, and Nepal).