Papillary cyst adenoma lymphomatosum: A case report and review

Mylarappa, Damodhar Arabagatte; Haragannvar, Vanishri C.; Gopalkrishna, Aparna H.; Joy, A. Reshma; Latha, D.; Archana, V

doi:10.15713/ins.jmrps.5

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…According to the WHO classification, all types of salivary glands tumors are pathologically diagnosed (2,3) , and the majority is benign mixed tumors (4) which has a tendency for recurrence with a malignant transformation in some cases (5) . The second common benign cystic tumor of the salivary gland is papillary cystadenomalymphomatosum (Warthin's tumor) (6).…”

Section: Introductionmentioning

confidence: 99%

The differences between benign mixed tumor and papillary cystadenoma lymphomatosum in proliferative, apoptotic, and antiapoptotic activity

Khaleel¹

2019

ATMPH

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The majority of salivary glands tumors are benign mixed tumors. The present study was aimed to evaluate the differences between benign mixed salivary glands tumor and papillary cystadenoma lymphomatous regarding the tumor cell proliferation rate, apoptotic and antiapoptotic activity. The study was performed on archived paraffinembedded salivary glands tissue of 23 benign mixed tumors and five cystadenoma lymphomatosis. Sections were stained with hematoxylin and eosin and cases with the definite diagnosis were selected for immunohistochemistry. The immunoreactivity was assessed in areas of highest positivity regarding Ki-67, P53, and bcl-2. Our results refer that benign mixed tumor and papillary cystadenoma lymphomatous showed negative immune expression for Ki-67. The P53 immune staining in benign mixed tumor appeared negative, while the papillary cystadenoma lymphomatous appeared with mild positive staining. Bcl-2 immune expression in the benign mixed tumor was moderate positive while the papillary cystadenoma lymphomatous was mild positive. We conclude that the benign mixed tumors showed significantly more Ki-67 and bcl-2 immune labeling indexes than papillary cystadenoma lymphomatous, but the P53 immune expression was less (p<0.05). This indicates that the P53 expression was not observed to be correlated with the Ki-67 or bcl-2 overexpression.

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Section: Introductionmentioning

confidence: 99%

The differences between benign mixed tumor and papillary cystadenoma lymphomatosum in proliferative, apoptotic, and antiapoptotic activity

Khaleel¹

2019

ATMPH

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show abstract

“…According to the WHO classification, all types of salivary glands tumors are pathologically diagnosed [2,3] , and the majority are benign mixed tumors [4] which have a tendency for recurrence with a malignant transformation in some cases [5] . The second common benign cystic tumor of the salivary gland is papillary cystadenoma lymphomatosum (Warthin's tumor) [6]. Ki-67 immunoreactivity is a prognostic factor in head and neck cancer and considered as a marker for cell proliferation and a better indicator for the aggressiveness of the tumor [7] .…”

Section: Introductionmentioning

confidence: 99%

The Differences between Benign Mixed Tumor and Papillary Cystadenoma Lymphomatosum in Proliferative, Apoptotic and Antiapoptotic Activities

Khaleel¹

2020

ATMPH

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Background:The majority of salivary glands tumors are benign mixed tumors. The present study was aimed to evaluate the differences between benign mixed salivary glands tumor and papillary cystadenoma lymphomatosum regarding the tumor cell proliferation rate, apoptotic and antiapoptotic activities. Methods: The study was performed on archived paraffin-embedded salivary glands tissue of 23 benign mixed tumor and five cystadenoma lymphomatosum. Sections were stained with hematoxylin and eosin and cases with definite diagnosis were selected for immunohistochemistry. The immunoreactivity was assessed in areas of highest positivity regarding Ki-67, P53 and bcl-2. Results: Benign mixed tumor and papillary cystadenoma lymphomatosum showed negative immune expression for Ki-67. The P53 immune staining in benign mixed tumor appeared negative while the papillary cystadenoma lymphomatosum appeared with a mild positive staining. The bcl-2 immune expression in benign mixed tumor was moderately positive while the papillary cystadenoma lymphomatosum was mildly positive. Conclusion:The benign mixed tumors showed significantly more Ki-67 and bcl-2 immune labeling indexes than papillary cystadenoma lymphomatosum, but the P53 immune expression was less (P<0.05). This indicated that the P53 expression was not correlated with the Ki-67 or bcl-2 over expression.

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“…In 1929, Warthin's called this tumor as papillary cystadenoma lymphomatosum. Currently, this tumor is called as adenolymphoma, Warthin's tumor, and cystic papillary adenoma (2) . Warthin's tumors occur almost exclusively in the parotid glands, in its superficial lobe and rarely in the deeper lobe (10%).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical differentiation of proliferative activity in Warthin's tumor & different types of adenoid cystic carcinoma (p53, PCNA & CD34)

Kamal

Mohamed

Alazazi

et al. 2019

Advanced Dental Journal

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Aim: To study the expression of p53, PCNA & CD34 and differentiate the proliferative activity and angiogenesis of Warthin's tumor & different types of adenoid cystic carcinoma. Methods: Hematoxylin and Eosin (H&E) and immunohistochemical staining techniques were used to detect p53, PCNA & CD34 proteins in 20 cases of Warthin's tumor & different types of adenoid cystic carcinoma (solid, tubular & cribriform pattern). Evaluation of immunostaining was done using computer image analyzer system & all data were statistically analyzed. Results: There was a statistically significant difference (P<0.05) in means of expression of p53, PCNA & CD34 between Warthin's tumor & different types of adenoid cystic carcinoma. Conclusion: The expression of p53, PCNA & CD34 have been associated with aggressive tumor progression and thus has been implicated as a predictive and prognostic marker and could provide useful prognostic markers for proliferative activity and good prognostic indicators for recurrence rate of adenoid cystic carcinoma.

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Papillary cyst adenoma lymphomatosum: A case report and review

Cited by 4 publications

References 5 publications

The differences between benign mixed tumor and papillary cystadenoma lymphomatosum in proliferative, apoptotic, and antiapoptotic activity

The differences between benign mixed tumor and papillary cystadenoma lymphomatosum in proliferative, apoptotic, and antiapoptotic activity

The Differences between Benign Mixed Tumor and Papillary Cystadenoma Lymphomatosum in Proliferative, Apoptotic and Antiapoptotic Activities

Immunohistochemical differentiation of proliferative activity in Warthin's tumor & different types of adenoid cystic carcinoma (p53, PCNA & CD34)

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