Papillary glioneuronal tumor: a case report of the cerebral aqueduct and review of literature

Hoshino, Hillary Sayuri Ramires; Santos, Bruna Grazielle Silva dos; Nogueira, Adriano Barreto; Guimarães, Antonio Celso Alvarenga

doi:10.1080/02688697.2021.1967290

Cited by 1 publication

(3 citation statements)

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“…Approximately just under 140 papillary glioneuronal tumor cases were revealed by reviewing the literature until 2017, and less than 20 patients with PGNTs have been recorded from 2017 to 2021 [6][7][8][9][10][11]. It mostly affects young adults in age around 25 years old, however, it has been reported in all age groups (range 2-75 years old) [7,8,12]. In a systematic review of Ahmed et al in 2017, it is reported that 80% of PGNT cases concern patients less than 40 years old [8].…”

Section: Discussionmentioning

confidence: 99%

“…In a systematic review of Ahmed et al in 2017, it is reported that 80% of PGNT cases concern patients less than 40 years old [8]. While in most papers it is supported that there is no gender predilection, some authors suggest that PGNT is more frequent in males [5,7,8].…”

Section: Discussionmentioning

confidence: 99%

“…In the new WHO classification in 2021, PRKCA is regarded as a key-diagnostic gene for papillary glioneuronal tumors [1]. This type of cancer in general has a low proliferation index (Ki67 ≈ 1-2%) [7,13]. Only in a pooled analysis of Ahmed et al in 2017, it was mentioned that average Ki67 of PGNT accounts of 3.6% [8].…”

Section: Discussionmentioning

confidence: 99%

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Papillary Glioneuronal Tumor of Third Ventricle Endoscopically Treated: Case Report and Review of Literature

Solou¹,

EK²,

Ydreos³

et al. 2022

COS

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Introduction: Papillary Glioneuronal Tumor (PGNT) is a grade I tumor based on the new World Health Organization CNS tumor classification. Its special feature concerns its biphasic histologic pattern of both glial and neuronal elements. Because of the rarity of this entity, literature is mostly based on case reports. Research Question: The objective of this paper is to display our experience treating endoscopically a papillary glioneuronal tumor located into the third ventricle in an adult patient and to highlight the main points of the literature. Material & Methods: A 75-year-old patient with known Parkinson disease presented with episodes of loss of consciousness and gait disorders in our institution. Brain MRI demonstrated enlargement of ventricular system due to an obstruction caused by an intraventricular tumor in the third ventricle. Results: Patient underwent an endoscopic subtotal removal of the tumor. Postoperative brain CT scan revealed minor residual of the tumor and patient was discharged 2 days after surgery in good clinical condition. Histopathological analysis of the tumor samples matched the diagnosis of PGNT. Postoperative follow-up in 1 month demonstrated great neurological improvement. Discussion & Conclusion: Literature reports that total surgical resection is the treatment of choice in almost all cases of PGNT giving the most favorable clinical outcome. Only 4 cases of PGNT located in 3rd ventricle have been recorded and data for endoscopic management found only for one of the cases concerning a pediatric patient. Therefore, we report for first time removal of third ventricle papillary glioneuronal tumor in adult patients via the endoscopic technique.

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