Papillary Glioneuronal Tumor: Unexplored Entity

Lavrnić, Slobodan; Macvanski, Marija; Ristic-Balos, Dragana; Gavrilov, M; Damjanović, Dino; Gavrilović, Svetlana; Milićević, Miroslav; Skender-Gazibara, Milica; Stošić-Opinćal, Tatjana

doi:10.1055/s-0031-1280836

Cited by 1 publication

(3 citation statements)

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“…To date, 89 cases of PGNT have been reported in the English literature . Radiologically, most of these cases showed a cystic mass with a mural nodule in the periventricular location.…”

Section: Discussionmentioning

confidence: 99%

“…PGNT was originally described as a pathologically benign tumor with a favorable clinical outcome and a generally low Ki‐67 proliferation index in the range of 1–2% . However, recently, several cases of PGNT with atypical features or aggressive clinical behavior have been reported . To our knowledge, 12 cases of PGNT with high Ki‐67 index (10% or more) have been published in the English literature (Table ) …”

Section: Discussionmentioning

confidence: 99%

“…In the 2007 World Health Organization (WHO) classification, PGNT was included as a new entity in the WHO grade I mixed neuronal‐glial tumor category . Although PGNT has been previously reported as a clinically indolent and histologically benign tumor, a few recurrent cases have recently been described . Reports of atypical pathologic findings, including the presence of microvascular proliferation, necrosis and increased proliferative activity, have accumulated .…”

Section: Introductionmentioning

confidence: 99%

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Papillary glioneuronal tumor with a high proliferative component and minigemistocytes in a child

et al. 2014

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Papillary glioneuronal tumor (PGNT) is a rare type of primary brain tumor. Although PGNT has traditionally been defined as a clinically indolent neoplasm, several cases with high proliferative activity and tumor recurrence have recently been reported. We report a case of PGNT in a 12-year-old boy who presented with epilepsy and harbored a 64 mm cystic tumor with a high proliferative component in the right temporal lobe. (11) C-methionine positron emission tomography (PET) showed high uptake in the solid mass. Gross total resection of the tumor mass was achieved and the patient became seizure-free without any neurological deficits. Histologically, the tumor contained two distinct areas of a vasocentric papilliform structure and a desmoplastic component. Minigemistocytic cells and small necrotic regions were observed adjacent to the pseudopapillae. Immunohistochemical analyses revealed both glial and neuronal differentiation. The Ki-67 proliferation index was high (14%) in the area corresponding to the high uptake region in the (11) C-methionine PET. No tumor recurrence was observed 20 months after surgery. High proliferative PGNTs are rare and to our knowledge this is only the third pediatric case of PGNT with atypical features reported in the literature. Hence, we here review the reported cases of PGNT and discuss the clinical, radiological and histological features of this malignancy.

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“…To date, 89 cases of PGNT have been reported in the English literature . Radiologically, most of these cases showed a cystic mass with a mural nodule in the periventricular location.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%