Papillary Renal Cell Carcinoma Associated with Autosomal Dominant Polycystic Kidney Disease

Sulser, Tullio; Fehr, J; Hailemariam, Seife; Briner, J; Hauri, D

doi:10.1159/000282536

Cited by 10 publications

(10 citation statements)

References 7 publications

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“…In fact, the association of ADPKD with renal-cell cancer is rare. Only some 60 cases have been reported, which sug gests that the incidence in ADPKD does not exceed that in the normal population [20,21].…”

Section: Discussionmentioning

confidence: 97%

Transplantation in Autosomal Dominant Polycystic Kidney Disease without Nephrectomy

Knispel¹,

Klän²,

Offermann

et al. 1996

Urol Int

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Some transplantation centers still suggest nephrectomy in patients with autosomal dominant poycystic kidney disease (ADPKD) before kidney transplantation at least in selected cases. We wanted to learn whether prior nephrectomy is beneficial. The outcome of kidney transplantation in 47 consecutive ADPKD patients without prior nephrectomy was compared with that in matched controls with respect to complications of ADPKD. Although ADPKD patients were older than controls (mean, 50.1 vs. 40.3 years), there was no statistically significant difference in 1- and 5-year allograft survival between ADPKD patients and controls: 76.6 and 68.0%, respectively, in ADPKD patients, and 83.9 and 56.3% in controls. After a mean follow-up of 66.5 months 3 patients with ADPKD had cyst infections and were managed with antibiotics. Two patients had episodes of hematuria; neither required invasive therapy. There was no renal malignancy and clinical sign of urolithiasis in any patient. No posttransplantation nephrectomy was required. With only few indications remaining, there is no rationale for routine pretransplantation nephrectomy in patients with ADPKD.

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Section: Discussionmentioning

confidence: 97%

Transplantation in Autosomal Dominant Polycystic Kidney Disease without Nephrectomy

Knispel¹,

Klän²,

Offermann

et al. 1996

Urol Int

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“…Of 44 patients, they also reported that 9 cases (20%) were PRCC as in our present cases, significantly higher than that of the general population (12%) ( Table I). Among these cases, five were type 1 and three weretype 2 [3][4][5]. However, it is also true that ESRD developed into multiple RCC much more often compared to sporadic RCC: 1.6% to 8.0% of the patients with ESRD, of whom 23% to 58% of the patients had acquired cystic disease of kidney (ACDK) [7].…”

Section: Discussionmentioning

confidence: 99%

Bilateral papillary renal cell carcinoma and angiomyolipoma in the patients with autosomal dominant polycystic kidney disease: of two cases and literature review

Konosu-Fukaya¹,

Nakamura²,

Fujishima³

et al. 2013

pjp

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We herein report two rare cases of bilateral renal neoplasms associated with autosomal dominant polycystic kidney disease (ADPKD). Case 1: Bilateral nephrectomy was performed on bilateral renal masses in a 58-year-old man with ADPKD. Case 2: Bilateral nephrectomy was performed on bilateral renal masses in a 32-year-old man with clinically suspected ADPKD. In case 1, angiomyolipoma (AML) and papillary renal cell carcinoma (PRCC) (type 1) were detected in the bilateral kidneys. In case 2, PRCC (type 1) was detected in the bilateral kidneys.

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“…To our knowledge, only 54 cases of RCC arising in patients with ADPKD have been reported 1-13. The association between RCC and chronic renal failure in patients with ADPKD remains controversial.…”

Section: Discussionmentioning

confidence: 99%

“…In these cases, clear cell RCC was the most common histological subtype (48%), followed by papillary RCC (14%) 1-13. There were only two cases with the coexistence of different histological subtypes of RCC 3,5.…”

mentioning

confidence: 96%

Multifocal Renal Cell Carcinoma of Different Histological Subtypes in Autosomal Dominant Polycystic Kidney Disease

Kim

Park

et al. 2012

Korean J Pathol

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Renal cell carcinoma (RCC) in autosomal dominant polycystic kidney (ADPKD) is rare. To date, 54 cases of RCC in ADPKD have been reported. Among these, only 2 cases have different histologic types of RCC. Here we describe a 45-year-old man who received radical nephrectomy for multifocal RCC with synchronous papillary and clear cell histology in ADPKD and chronic renal failure under regular hemodialysis. The case reported herein is another example of the rare pathological finding of RCC arising in a patient with ADPKD.

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Papillary Renal Cell Carcinoma Associated with Autosomal Dominant Polycystic Kidney Disease

Cited by 10 publications

References 7 publications

Transplantation in Autosomal Dominant Polycystic Kidney Disease without Nephrectomy

Transplantation in Autosomal Dominant Polycystic Kidney Disease without Nephrectomy

Bilateral papillary renal cell carcinoma and angiomyolipoma in the patients with autosomal dominant polycystic kidney disease: of two cases and literature review

Multifocal Renal Cell Carcinoma of Different Histological Subtypes in Autosomal Dominant Polycystic Kidney Disease

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