Papillary Squamous Cell Carcinoma of the Trachea Associated with Human Papillomavirus-18 Infection

Abstract

A 75-year-old man presented with the chief complaints of coughing and dyspnea. Chest computed tomography revealed narrowing of the trachea. A tumor measuring 40×33×15 mm in size that caused -90% reduction in the cross-sectional area of the trachea 4 cm above the carina was cauterized with high-frequency electrocautery via a rigid bronchoscope. A pathological examination revealed papillary squamous cell carcinoma with immunohistochemical p16 overexpression. Multiplex polymerase chain reaction confirmed human papillomavirus type 18 DNA in the tumor. At the 12-month follow-up visit following the administration of radiotherapy, the patient exhibited no local recurrence or distant metastasis.

Pulmonary papillary squamous cell carcinoma: a population-based analysis of incidence, treatment, and prognosis

“…HPV has been proven to act in wide-range cancers (20)(21)(22). In addition, among studies of PSCC on other sites, especially head and neck, HPV participates in the development of PSCC (19,(23)(24)(25). Paradoxically, for certain types of SCCs, HPVpositive tumors tend to have both overall and diseasespecific survival benefits compared with HPV-negative tumors (26,27).…”

Incidence and therapeutic strategies for the management of pulmonary papillary cell carcinoma

“…The association between papillomavirus and squamous cell carcinomas has been described, especially in immunocompromised patients. However, it remains unclear if HPV is associated with the development of pulmonary PSCC (10)(11)(12)(13)(14). Also, there was no convincing evidence of a clear causal relationship between smoking and pulmonary PSCC, which is the case for the rest of the pulmonary SCC.…”