Papillary thyroid carcinoma in a 3-year-old child: Case report

Alkan, Seyhan; Seven, Hüseyin; Sakalli, Erdal; Dadaş, Burhan

doi:10.1016/j.ijporl.2007.10.014

Cited by 8 publications

(16 citation statements)

References 14 publications

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“…9,12 Our presented case, along with 2 other similar cases that involved children less than 4 years old diagnosed with papillary thyroid carcinoma are all male patients. 2,4 This is consistent with the previous reports of increased male predominance in younger children. 9,12 Clinically, the differential diagnosis for young pediatric patients of neck mass includes infections, neoplasms including lymphomas, and congenital abnormalities.…”

Section: Discussionsupporting

confidence: 93%

“…As the most common form of DTC in children, papillary thyroid carcinoma constitutes 85% to 95% of the cases. [1][2][3][4] Most studies cite a female predominance of DTC ranging from 3 to 6:1, 3,7,10,11 whereas other studies have found that in very young children (<10 y old) there is a male predominance as high as 6:1, which shifts back to a female predominance in adolescence. 9,12 Our presented case, along with 2 other similar cases that involved children less than 4 years old diagnosed with papillary thyroid carcinoma are all male patients.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] The most common type of DTC encountered in children is papillary thyroid carcinoma, most of which are believed to be related to radiation exposure 5,6 and only approximately 5% of cases have a family history of papillary thyroid carcinoma. 7 DTC is exceptionally rare in children younger than 5 years old.…”

mentioning

confidence: 99%

“…When compared with adults, pediatric DTCs show a more aggressive clinical course with 60% to 80% presenting with regional lymph node metastasis and 10% to 20% with pulmonary metastasis. 1,2,4,[7][8][9] In this case report, we present a 3year-old American boy diagnosed with papillary thyroid carcinoma who has a family history of thyroid cancer and thyroid disease but no known history of radiation exposure, followed by a literature review with discussion on the management and treatment of pediatric thyroid papillary carcinoma.…”

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confidence: 99%

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Thyroid Papillary Carcinoma in a 3-year-old American Boy with a Family History of Thyroid Cancer

Khara

Silverman²,

Bethel³

et al. 2010

Journal of Pediatric Hematology/Oncology

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Differentiated thyroid carcinoma is a rare malignancy in children. It represents 0.4% to 3.0% of all childhood malignancies, with greater than 70% of cases presenting between the ages of 11 to 17 years and is exceptionally rare in children under 5 years of age. The most common type of differentiated thyroid carcinoma in children is papillary thyroid carcinoma, most of which are believed to be related to radiation exposure and only approximately 5% of cases have a family history of papillary thyroid cancer. In this report, we present a papillary thyroid carcinoma in a 3-year-old American boy with a family history of thyroid cancer and no known history of radiation exposure. A literature review with discussion on the management and treatment of pediatric papillary thyroid carcinoma follows.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Thyroid Papillary Carcinoma in a 3-year-old American Boy with a Family History of Thyroid Cancer

Khara

Silverman²,

Bethel³

et al. 2010

Journal of Pediatric Hematology/Oncology

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“…Thyroid nodules seem to be rare disorders in children and adolescents, although thyroid cancers are extremely rare in the pattern of thyroid pathologies, especially at ages younger than 5 years [6,9]. Thyroid cancers occur in 0.5-3.0% of all pediatric malignancies [1,14]. One of the most difficulties in nodular thyroid disease is the absence of any clinical signs, such as pain of the anterior surface of the neck, high temperature, skin rash or discomfort in that region.…”

Section: Introductionmentioning

confidence: 99%

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2016

RJLBPCS

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ABSTRACT:The incidence of follicular thyroid cancer (FTC) varies in different countries and is more common in women increasing with age in general population. There is lack of similar data concerning paediatric population. FTA is difficult to diagnose by fine-needle aspiration, thus any follicular thyroid tumor need to be excised for further identification of its malignant or benign character. Overwhelming majority of FTC cases are asymptomatic and euthyroid, which exacerbate the early diagnosis and clinical manifestation of thyroid nodules. Therefore they are detected by routine physical examination without clinical signs of thyroid dysfunction. USG examination is useful for monitoring nodule size and for the fine-needle aspiration (FNA) of nodules and cysts, but not for identifying of cancers. We present a case report of a 3.5 years old child with swelling of the left lateral-anterior aspect of the neck without clinical complaints that was first noticed about 4 months before. There was no family history of any cancers, nor a history of exposure to radiation. TSH and free T4 levels, as well as autoantibodies against thyroid gland were measured and found to be in normal ranges. A nodule of 4.2cm in diameter by USG examination, and follicular neoplasm by ultrasound-guided FNA has been revealed. Surgical excision -lobectomy was performed with further histology of the tumor. The final pathohistological diagnosis was follicular carcinoma, which is very rare state in children. Postoperatively the boy was not administrated levothyroxine suppressive therapy to escape unnecessary side effects from excess of hormone intake. He is under intensive monitoring up to now. After 5 years of monitoring no other nodule development was dated, euthyroidism clearly remain, lymphadenopathy of neck is absent.

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Papillary Thyroid Carcinoma in Children and Adolescents

Chung

Park

Kim

et al. 2014

Ultrasound Quarterly

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Differentiated thyroid carcinoma is uncommon in children and constitutes 0.5% to 3% of all pediatric malignancies. Few studies have reported imaging findings of childhood papillary thyroid carcinomas. We report 3 cases of papillary thyroid carcinomas in children. Among the 3 patients, the youngest was a 7-year-old girl. In the current report, we describe 2 cases of classic papillary thyroid carcinoma and 1 case of pediatric diffuse sclerosing variant of papillary thyroid carcinoma. The ultrasonographic features and diagnostic procedures in these pediatric patients are similar to those in adults.

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Papillary thyroid carcinoma in a 3-year-old child: Case report

Cited by 8 publications

References 14 publications

Thyroid Papillary Carcinoma in a 3-year-old American Boy with a Family History of Thyroid Cancer

Thyroid Papillary Carcinoma in a 3-year-old American Boy with a Family History of Thyroid Cancer

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Papillary Thyroid Carcinoma in Children and Adolescents

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