Papillary Thyroid Carcinoma that Metastasised to the Choroid

Abarca, Pedro; Ponce, José Luis; Prieto, Mireya; López-Aznar, D; S, Sancho-Fornos

doi:10.1080/110241599750008161

Cited by 10 publications

(5 citation statements)

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“…External beam radiotherapy, I 131 ablation therapy and enucleation have been employed based on the extent of the tumor, the potential for visual improvement and the systemic status of the patient [3-9]. In our patient, transpupillary thermotherapy resulted in satisfactory regression of the solitary choroidal metastatic tumor in the left eye.…”

Section: Discussionmentioning

confidence: 72%

“…Uveal metastatic thyroid carcinoma was found in patients who had their primary cancer diagnosed and treated for an average of 9.9 years (range, 4 to 30 years) [4-9]. In 2 cases, uveal metastases were the initial presentations of the papillary thyroid cancer [3,8].…”

Section: Discussionmentioning

confidence: 99%

“…In 2 cases, uveal metastases were the initial presentations of the papillary thyroid cancer [3,8]. Reported ocular signs and symptoms included a sudden loss of visual acuity, loss of color discrimination, visual field defects, and light flashes [3-9]. The majority of these patients had a solitary, amelanotic, orange-yellow choroidal mass sometimes associated with serous or hemorrhagic retinal detachment [3-7,9].…”

Section: Discussionmentioning

confidence: 99%

“…Reported ocular signs and symptoms included a sudden loss of visual acuity, loss of color discrimination, visual field defects, and light flashes [3-9]. The majority of these patients had a solitary, amelanotic, orange-yellow choroidal mass sometimes associated with serous or hemorrhagic retinal detachment [3-7,9]. Three patients had bilateral choroidal involvement [3,7,8].…”

Section: Discussionmentioning

confidence: 99%

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Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension

Kıratlı

Tarlan

Söylemezoğlu

2013

Korean J Ophthalmol

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Here, we present the case of a patient with bilateral choroidal metastases with extraocular extension in one eye. Metastasis of papillary thyroid carcinoma to the uvea is extremely rare, with only 6 patients reported in the literature. A 62-year-old man with a prior history of papillary thyroid carcinoma suffered the rapid loss of vision in his right eye. He had neovascular glaucoma, total retinal detachment, and a solitary choroidal mass. A month later, his left visual acuity also decreased because of a small macular choroidal mass. The right eye was enucleated and a nodular lesion over the sclera representing extraocular extension was observed. This tumor and the intraocular lesion were composed of papillary excrescences and cystic spaces and stained positively for thyroid transcription factor 1 and thyroglobulin, all confirming the diagnosis of metastatic papillary thyroid carcinoma. The tumor in the left eye was successfully treated with diode laser transpupillary thermotherapy. The patient expired within a month as a result of widespread pulmonary metastases. Papillary thyroid carcinoma may metastasize to the uvea bilaterally, cause rapid visual function loss, erode the sclera, and may extend outside the globe similar to choroidal melanoma. This aggressive ocular involvement was associated with a dismal prognosis in our patient.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension

Kıratlı

Tarlan

Söylemezoğlu

2013

Korean J Ophthalmol

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“…Clinically, patients generally present with symptoms of pain and impairment of vision. Ophthalmoscopic examination generally shows an orange-yellow lesion [11]. Diagnosis is established by imaging modalities like fluoroscein angiography, B-mode ultrasonography and MRI.…”

Section: Discussionmentioning

confidence: 99%

Iodophilic Synchronous Phalangeal and Choroidal Metastasis from Follicular Thyroid Carcinoma: A Case Report and Review

Patil¹,

Kattepur²,

Gopinath³

et al. 2014

Eur Thyroid J

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Background: Follicular thyroid cancers constitute 15-20% of all thyroid tumors. The usual mode of dissemination is via the hematogenous route. The most common sites of distant metastasis are to the lungs and bones. Objective: A case is presented to demonstrate the unusual presentation of follicular cancer with synchronous digital (distal phalanx of the little finger) and choroidal metastasis that was responsive to radioiodine treatment. Case Report: A 54-year-old female presented with swelling over the terminal part of the left little finger with thyromegaly. Investigations revealed metastasis from follicular thyroid cancer to the little finger along with pulmonary metastases. She underwent total thyroidectomy with central compartment clearance followed by ¹³¹I therapy. Subsequent follow-up demonstrated complete regression of the digital metastasis and partial regression of the choroidal metastasis which was evaluated after the radioiodine scan that picked up the choroidal metastasis. Conclusion: Follicular thyroid cancers can rarely spread to unusual sites like the digits and choroid. This report highlights the synchronous presentation of digital and choroidal metastasis which responded to ¹³¹I therapy.

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A Summary of Rare Sites of Metastasis Secondary to Differentiated Thyroid Cancer

et al. 2016

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Papillary Thyroid Carcinoma that Metastasised to the Choroid

Cited by 10 publications

References 0 publications

Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension

Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension

Iodophilic Synchronous Phalangeal and Choroidal Metastasis from Follicular Thyroid Carcinoma: A Case Report and Review

A Summary of Rare Sites of Metastasis Secondary to Differentiated Thyroid Cancer

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