Papillomatosis of the common bile duct associated with ampullary carcinoma.

Fava, Marcelo; Foradori, G; Cruz, F; Guzmán, Sergio

doi:10.2214/ajr.156.2.1898828

“…Hepatic transplantation has also been proposed as an alternative approach to therapy. 21 Tissue biopsy is required for a definitive preoperative diagnosis. 19 Correct preoperative diagnosis of BP with liver involvement is difficult, if not impossible.…”

Section: Fna Of Biliary Papillomatosismentioning

confidence: 99%

Fine-needle aspiration cytologic diagnosis of intrahepatic biliary papillomatosis (intraductal papillary tumor): Report of three cases and comparative study with cholangiocarcinoma

Tsui

¹

,

Lam

²

,

Mak

³

et al. 2000

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Biliary papillomatosis is a rare tumor of the intrahepatic and extrahepatic biliary tree, and its FNA findings have not been reported. The cytologic features of 3 cases of intrahepatic biliary papillomatosis were studied and compared with 5 cases of cholangiocarcinoma. The distinctive features include: 1) hypercellular smear, 2) very broad and often double‐cell layered sheets of ductal columnar epithelium, 3) papillary configuration, 4) preserved honeycomb pattern with even nuclear spacing, and 5) dysplastic but not frankly malignant nuclear features. The constellation of these features is highly characteristic of biliary papillomatosis and helpful in distinguishing it from cholangiocarcinoma and other differential diagnoses. A firm preoperative diagnosis can thus be achieved, allowing better planning in management of this borderline malignant tumor. Diagn. Cytopathol. 2000;22:293–298. © 2000 Wiley‐Liss, Inc.

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“…22 The cholangiographic finding of multiple or extensive lesions in the biliary tree may suggest the diagnosis. 21 Tissue biopsy is required for a definitive preoperative diagnosis. In contrast to its histopathologic features, the FNA cytologic findings have never been described in the literature, probably because of its rare occurrence.…”

Section: Fna Of Biliary Papillomatosismentioning

confidence: 99%

“…No diagnostic radiologic features have been documented. 21,22 To our knowledge, fine-needle aspiration (FNA) findings of this rare entity have not been reported. In this study, we describe the FNA cytologic characteristics of 3 cases of BP of the liver, only one of which was correctly diagnosed preoperatively based on the cytology.…”

mentioning

confidence: 99%

Fine-needle aspiration cytologic diagnosis of intrahepatic biliary papillomatosis (intraductal papillary tumor): Report of three cases and comparative study with cholangiocarcinoma

Tsui

¹

,

Lam

²

,

Mak

³

et al. 2000

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Biliary papillomatosis is a rare tumor of the intrahepatic and extrahepatic biliary tree, and its FNA findings have not been reported. The cytologic features of 3 cases of intrahepatic biliary papillomatosis were studied and compared with 5 cases of chol-Key Words: biliary papillomatosis; intraductal papillary tumor; cholangiocarcinoma; biliary tumor; liver; FNA; cytology Biliary papillomatosis (BP) or intraductal papillary tumor is a rare tumor characterized by multiple papillary adenomas involving extensive areas of the intrahepatic and/or extrahepatic biliary tree, and has a great potential for multicentric malignant transformation. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Preoperative diagnosis is usually difficult. Tumors involving the extrahepatic bile ducts can be confirmed by endoscopic means, including biopsy and brush cytology. For intrahepatic tumors, the imaging techniques often reveal a mass lesion. No diagnostic radiologic features have been documented. 21,22 To our knowledge, fine-needle aspiration (FNA) findings of this rare entity have not been reported. In this study, we describe the FNA cytologic characteristics of 3 cases of BP of the liver, only one of which was correctly diagnosed preoperatively based on the cytology. It appears that the main differential diagnosis in cytology is cholangiocarcinoma; a comparative study is also made. Materials and MethodsThree cases of intrahepatic BP with FNA of the tumor before surgical resection were encountered. The available clinical information was studied. Both the cytologic and histologic sections were reviewed, and their findings were correlated. The cytologic smears of 5 consecutive cases of cholangiocarcinoma (tubular type of adenocarcinoma) confirmed by clinical investigation and/or subsequent excision were reviewed. Their findings were compared to the present 3 cases in an attempt to identify those cytologic features that should allow the recognition of BP.In all cases, the aspiration was performed with ultrasound guidance. Direct smears prepared from the aspirates were wet fixed in 95% ethanol and stained with hematoxylineosin (H&E) and Papanicolaou stains. Tissue fragments aspirated into the syringe and remaining in the needle were rinsed into and fixed in a 7.5% neutral-buffered formalin solution. Cell blocks were prepared with 3% agar as an adjuvant and processed according to a schedule with slightly shortened xylene steps. The standard 4-m sections were stained with H&E.

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Sonographic features of mucinous biliary papillomatosis: Case report and review of imaging findings

Khan¹,

Wilson²,

Sherlock³

et al. 1998

J. Clin. Ultrasound

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Papillomatosis of the common bile duct associated with ampullary carcinoma.

Cited by 6 publications

References 0 publications

Fine-needle aspiration cytologic diagnosis of intrahepatic biliary papillomatosis (intraductal papillary tumor): Report of three cases and comparative study with cholangiocarcinoma

Fine-needle aspiration cytologic diagnosis of intrahepatic biliary papillomatosis (intraductal papillary tumor): Report of three cases and comparative study with cholangiocarcinoma

Fine-needle aspiration cytologic diagnosis of intrahepatic biliary papillomatosis (intraductal papillary tumor): Report of three cases and comparative study with cholangiocarcinoma

Sonographic features of mucinous biliary papillomatosis: Case report and review of imaging findings

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