“…First reported in 1984 by Chorzelski, PAD is a type of focal acantholytic dyskeratosis characterized by skin colored to grayish white smooth or verrucous papules, plaques most commonly localized to vulva, penis, scrotum, perianal, and inguinal folds. [ 1 ] Although mostly asymptomatic, the lesions may be pruritic, painful, or burning. Pathogenesis is poorly understood but few reports show that heterozygous mosaic mutations in ATP2A2 (Darier’s) and ATP2C1 (Hailey Hailey) genes may cause PAD.…”