2020
DOI: 10.1111/ajd.13404
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Papular acantholytic dyskeratosis

Abstract: After a symptom-free interval, a relapse was noted on day of life 120, when she developed rapidly expanding skin lesions with diffuse flaccid bullae and epidermal peeling on the lower extremities (Fig. 1c and d). Antibiotics (teicoplanin and amikacin) were administered again for 10 days, together with analgesics and aseptic care. No systemic features was observed. Staphylococcus aureus was cultured only from the skin cultures. Genetic test for epidermolysis bullosa was negative. Skin biopsy showed splitting at… Show more

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Cited by 3 publications
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“…First reported in 1984 by Chorzelski, PAD is a type of focal acantholytic dyskeratosis characterized by skin colored to grayish white smooth or verrucous papules, plaques most commonly localized to vulva, penis, scrotum, perianal, and inguinal folds. [ 1 ] Although mostly asymptomatic, the lesions may be pruritic, painful, or burning. Pathogenesis is poorly understood but few reports show that heterozygous mosaic mutations in ATP2A2 (Darier’s) and ATP2C1 (Hailey Hailey) genes may cause PAD.…”
mentioning
confidence: 99%
“…First reported in 1984 by Chorzelski, PAD is a type of focal acantholytic dyskeratosis characterized by skin colored to grayish white smooth or verrucous papules, plaques most commonly localized to vulva, penis, scrotum, perianal, and inguinal folds. [ 1 ] Although mostly asymptomatic, the lesions may be pruritic, painful, or burning. Pathogenesis is poorly understood but few reports show that heterozygous mosaic mutations in ATP2A2 (Darier’s) and ATP2C1 (Hailey Hailey) genes may cause PAD.…”
mentioning
confidence: 99%