Papular Urticaria - An early marker of Atopic March

JAYAKAr, Thomas; Selva, Psk; Manoharan, D; Ashok, KN; Cynthia, S; Ashwak, A

doi:10.4314/sjd.v8i2.68354

Cited by 5 publications

(8 citation statements)

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“…Unfortunately, children affected by these eruptions are frequently misdiagnosed and often subject to expensive evaluations including invasive and unnecessary procedures (9) . In our study, age distribution of was around 60% at age between 1-10 yrs and this agrees with the results of other researchers who found that papular urticaria predominantly in children aged 0-5 yrs (10) . In this study gender distribution of studied patients was around 57% shows that female tendancy of papular urticaria and this agree with other authors, as papular urticaria is more common in females than males (11) .…”

Section: Discussionsupporting

confidence: 93%

“…And this agrees with this study, as atopic background was present in 60% of patients, and 20% of patients have positive family history of papular urticaria. In this study we estimated the IgE level and we found a boarderline high level in 90% of the patients and that agrees with the results of other researchers who found an increase in IgE level in high percentage of papular urticaria patients (10) . We also determined IL-4 level in papular urticaria patients; however there is no research addressed the same subject.…”

Section: Discussionsupporting

confidence: 92%

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Assessment of Immunoglobulin-E and Interleukin-4 Levels in Papular Urticaria Patients

Ewais

Eyada

Attia

et al. 2016

Suez Canal University Medical Journal

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Background: Papular urticaria is a common and often annoying disorder manifested by chronic papules caused by a hypersensitivity reaction. The link between atopic immune responses (high serum IgE, IL-4) and the development of rash is clear and has been extensively evaluated in the literature. Aim: This study was designed to find possible co relation between serum levels of IgE and IL-4 and popular urticaria. Patient and Methods: A case control study was done that included 30 patients and 30 controls who were selected randomly according to the eligibility criteria. Assessment of serum IG-E and IL-4 levels was evaluated using sandwich ELISA approach. Results: Twenty-six patients (87%) have borderline level of IgE, 1 (3%) have high level, while normal IgE level was found in 3 (10%). In the control group, 3 subjects (10%) have borderline level of IgE and 27 (90%) have normal level, while no subject had high IgE level were found. Conclusions: The present study confirmed the significantly higher values of serum IgE and IL-4 in papular urticaria patients. There was statistically significant correlation between the IL-4 and IgE levels in papularr urticaria patients.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Assessment of Immunoglobulin-E and Interleukin-4 Levels in Papular Urticaria Patients

Ewais

Eyada

Attia

et al. 2016

Suez Canal University Medical Journal

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“…The reason for the under nutrition recorded in 41.5% of patients in this study could be due to advanced immunosuppression which could be associated with opportunistic infection. More so, it is documented that disease progression and viral load increments in HIV patients lead to overproduction of cytokines such as TNF that culminates in weight loss [28].…”

Section: Discussionmentioning

confidence: 99%

Frequency and clinico-topographic distribution patterns of pruritic papular eruption in HIV patients in a Nigerian Tertiary Hospital

Ekpe¹,

Forae²,

Okwara³

2019

Our Dermatol Online

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“…It has been proven in a study that the absolute eosinophil count (AEC) and the serum IgE levels were elevated in all patients presenting with papular urticaria and tested for the above parameters 1 . Another study revealed a predominant CD4+ positive T cells, eosinophil rich infiltrate and increased IgE response which suggests a Thelper 2 (T-h2) mediated response to the salivary protein 5 .…”

Section: Mechanism Of Papular Urticariamentioning

confidence: 99%

“…The disease is more common in children though adults may also be affected and usually history of atopy in the patient or family members is present. 70% of the individuals with papular urticaria had history of atopy in a study 1 . Children eventually outgrow the disease due to desensitization after multiple exposures 10 .…”

Section: Mechanism Of Papular Urticariamentioning

confidence: 99%