Papulopustular rosacea: Prevalence and relationship to photodamage

McAleer, Maeve A.; Fitzpatrick, Patricia; Powell, Frank C.

doi:10.1016/j.jaad.2009.04.024

Cited by 77 publications

(55 citation statements)

References 23 publications

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“…Several additional variants have been described (Wilkin et al ., 2002, 2004), although their subdivision into the entity rosacea is not yet clear. Rosacea prevalence is highest (between 2.7 and 10%) in patients of northern European or Celtic heritage (Webster, 2009; Abram et al ., 2010b; McAleer et al ., 2010). Humans with fair skin (Fitzpatrick skin phenotypes I–II) are more likely to be affected, whereas Asians and African Americans are less affected, indicating a genetic component (Abram et al ., 2010a).…”

Section: Classification and Epidemiology Of Rosaceamentioning

confidence: 99%

Clinical, Cellular, and Molecular Aspects in the Pathophysiology of Rosacea

Steinhoff

Buddenkotte

Aubert

et al. 2011

Journal of Investigative Dermatology Symposium Proceedings

244

221

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Rosacea is a chronic inflammatory skin disease of unknown etiology. Although described centuries ago, the pathophysiology of this disease is still poorly understood. Epidemiological studies indicate a genetic component, but a rosacea gene has not been identified yet. Four subtypes and several variants of rosacea have been described. It is still unclear whether these subtypes represent a “developmental march” of different stages or are merely part of a syndrome that develops independently but overlaps clinically. Clinical and histopathological characteristics of rosacea make it a fascinating “human disease model” for learning about the connection between the cutaneous vascular, nervous, and immune systems. Innate immune mechanisms and dysregulation of the neurovascular system are involved in rosacea initiation and perpetuation, although the complex network of primary induction and secondary reaction of neuroimmune communication is still unclear. Later, rosacea may result in fibrotic facial changes, suggesting a strong connection between chronic inflammatory processes and skin fibrosis development. This review highlights recent molecular (gene array) and cellular findings and aims to integrate the different body defense mechanisms into a modern concept of rosacea pathophysiology.

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Section: Classification and Epidemiology Of Rosaceamentioning

confidence: 99%

Clinical, Cellular, and Molecular Aspects in the Pathophysiology of Rosacea

Steinhoff

Buddenkotte

Aubert

et al. 2011

Journal of Investigative Dermatology Symposium Proceedings

244

221

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“…The prevalence of rosacea is reported to vary from 0.09 to 22% [1,2,3,4,5,6,7,8], although this range may reflect racial and geographic differences or differences in diagnostic criteria [1,5]. Rosacea has a wide spectrum of clinical features, which include persistent facial redness, flushing, telangiectasia, inflammatory papules/pustules, hypertrophy and/or ocular features.…”

Section: Introductionmentioning

confidence: 99%

“…Rosacea has a wide spectrum of clinical features, which include persistent facial redness, flushing, telangiectasia, inflammatory papules/pustules, hypertrophy and/or ocular features. The pathogenesis of rosacea remains unclear, although it is generally considered to be related to factors such as vasculature, climatic exposure, matrix degeneration, pilosebaceous unit abnormalities and microbial organisms [8,9,10,11]. Histologically, rosacea is characterized by dilated blood and lymphatic vessels, a perivascular infiltrate of increased T cells, macrophages and mast cells, and often solar elastosis and dermal edema [12].…”

Section: Introductionmentioning

confidence: 99%

Clinical Evaluation of 368 Patients with Nasal Rosacea: Subtype Classification and Grading of Nasal Rosacea

Lee¹,

Jung²,

Won³

et al. 2015

Dermatology

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Background: The clinical features of nasal rosacea have not been described in detail. Objective: To describe the clinical features of nasal rosacea. Methods: 599 patients were classified into those with rosacea in both the nasal and extra-nasal areas (group A), localized nasal rosacea (group B) and rosacea without nasal involvement (group C). Results: The mixed subtype was more common in group A (n = 337) than in group C (n = 231). The severity score was higher in group A than in group C. Erythematotelangiectatic rosacea was the most common subtype in group B (n = 31) and was more common in group B than in group A. Rosacea mainly affected the lower half of the nose in group B, but affected the entire nose in group A. Conclusion: Nasal involvement may be an index of severe rosacea. Localized nasal rosacea is a separate spectrum with different clinical features.

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“…More recently, large retrospective database studies have yielded prevalence rates ranging from 1.3% to 2.1%. [7][8][9][10][11][12] Such low rates may be misrepresentative since the administrative databases only recorded patients with severe rosacea symptoms, potentially missing a significant percentage of patients with mild disease.…”

Section: Natural History and Pathophysiological Mechanisms Underlyingmentioning

confidence: 99%

Update on the Management of Rosacea

Weinkle

Doktor

Emer

2015

Plastic Surgical Nursing

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Abstract:Refining diagnostic criteria has identified key characteristics differentiating rosacea, a chronic skin disorder, from other common cutaneous inflammatory conditions. The current classification system developed by the National Rosacea Society Expert Committee consists of erythematotelangiectatic, papulopustular, phymatous, and ocular subtypes. Each subtype stands as a unique entity among a spectrum, with characteristic symptoms and physical findings, along with an intricate pathophysiology. The main treatment modalities for rosacea include topical, systemic, laser, and light therapies. Topical brimonidine tartrate gel and calcineurin inhibitors are at the forefront of topical therapies, alone or in combination with traditional therapies such as topical metronidazole or azelaic acid and oral tetracyclines or isotretinoin. Vascular laser and intense pulsed light therapies are beneficial for the erythema and telangiectasia, as well as the symptoms (itching, burning, pain, stinging, swelling) of rosacea. Injectable botulinum toxin, topical ivermectin, and microsecond long-pulsed neodymium-yttrium aluminum garnet laser are emerging therapies that may prove to be extremely beneficial in the future. Once a debilitating disorder, rosacea has become a well known and manageable entity in the setting of numerous emerging therapeutic options. Herein, we describe the treatments currently available and give our opinions regarding emerging and combination therapies.

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Papulopustular rosacea: Prevalence and relationship to photodamage

Cited by 77 publications

References 23 publications

Clinical, Cellular, and Molecular Aspects in the Pathophysiology of Rosacea

Clinical, Cellular, and Molecular Aspects in the Pathophysiology of Rosacea

Clinical Evaluation of 368 Patients with Nasal Rosacea: Subtype Classification and Grading of Nasal Rosacea

Update on the Management of Rosacea

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