Para-testicular cellular angiofibroma: a rare tumour in a male renal transplant patient

Abstract

Cellular angiofibroma is a rare, benign, mesenchymal neoplasm that should be distinguished from other more aggressive mesenchymal lesions. A 32-year-old male presented with a painless para-testicular mass. Pathological examination showed features characteristic of cellular angiofibroma. He had a history of renal transplantation and was on immunosuppressive drugs. The pathogenesis of cellular angiofibroma is largely undetermined. The role of immunosuppressive therapy in the genesis of this tumour awaits further analysis.

Double Para-testicular Cellular Angiofibroma and Synchronous Testicular Microlithiasis

“…Cellular angiofibroma usually occurs as a solitary and circumscribed lesion in the inguinoscrotal region of men [ 1 - 5 , 7 ]. Multiple cellular angiofibromas are very rare.…”

“…Since first described by Nucci et al . in 1997 [ 1 ], this distinct histopathologic entity has been reported in a series of studies [ 2 - 4 ] and case reports [ 5 - 7 ]. The tumor is characterized by two principal components, cellular spindle cells and prominent blood vessels [ 1 ].…”

“…Mild cytologic atypia and a few mitotic figures have been demonstrated in some cases [ 2 , 4 ]. The tumor occurs mainly in the inguinoscrotal region in men [ 2 - 5 , 7 ]. The molecular pathogenesis of cellular angiofibroma is largely unknown, although retinoblastoma 1 (RB1) and forkhead box protein O1 (FOXO1) have been implicated in some cases [ 3 , 7 ].…”

Quiz. Correct answer to the quiz. Check your diagnosis Cellular angiofibroma with atypia or sarcomatous transformation – case description with literature review

“…In our case, six months after diagnosis, there have not been any signs and symptoms of the recurrence or metastasis in our case. Table I presents a summary of the literature review which includes a presentation of all cases of CAS reported to date [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Table I are based on a review of the following publications [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] …”

Sarcomatous transformation in a cellular angiofibroma: a case report

“…The term “cellular angiofibroma” was coined by Nucci et al to emphasise the two principal components of this tumour: a proliferation of uniform, bland, spindled cells set in a collagenous stroma with numerous thick-walled and often hyalinised blood vessels 1. Subsequently, several similar cases have been reported, most of which occurred in the vulvovaginal or inguinoscrotal region,2 3 4 5 with rare cases described in the retroperitoneum and subcutaneous tissue of the chest 6 7. In 2004, Iwasa and Fletcher described a series of 51 cases of cellular angiofibroma to further characterise its clinicopathological and immunohistochemical features 3.…”