Parabolic flight as a spaceflight analog

Shelhamer, Mark

doi:10.1152/japplphysiol.01046.2015

Cited by 55 publications

(38 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Resources for human hypogravity research are limited to interplanetary space missions and parabolic flights (44,50,52). Due to high expanses, experiments are rare and almost restricted to zero gravity (9,58).…”

Section: For the First Time This Article Documents Human Locomotor Bmentioning

confidence: 99%

Bouncing on Mars and the Moon—the role of gravity on neuromuscular control: correlation of muscle activity and rate of force development

Ritzmann

Freyler

Krause

et al. 2016

Journal of Applied Physiology

View full text Add to dashboard Cite

On our astronomical neighbors Mars and the Moon, bouncing movements are the preferred locomotor techniques. During bouncing, the stretch-shortening cycle describes the muscular activation pattern. This study aimed to identify gravity-dependent changes in kinematic and neuromuscular characteristics in the stretch-shortening cycle. Hence, neuromuscular control of limb muscles as well as correlations between the muscles' pre-activation, reflex components, and force output were assessed in lunar, Martian, and Earth gravity. During parabolic flights, peak force (F), ground-contact-time, rate of force development (RFD), height, and impulse were measured. Electromyographic (EMG) activities in the m. soleus (SOL) and gastrocnemius medialis (GM) were assessed before (PRE) and during bounces for the reflex phases short-, medium-, and long-latency response (SLR, MLR, LLR). With gradually decreasing gravitation, F, RFD, and impulse were reduced, whereas ground-contact time and height increased. Concomitantly, EMG_GM decreased for PRE, SLR, MLR, and LLR, and in EMG_SOL in SLR, MLR, and LLR. For SLR and MLR, F and RFD were positively correlated to EMG_SOL. For PRE and LLR, RFD and F were positively correlated to EMG_GM. Findings emphasize that biomechanically relevant kinematic adaptations in response to gravity variation were accompanied by muscle- and phase-specific modulations in neural control. Gravitational variation is anticipated and compensated for by gravity-adjusted muscle activities. Importantly, the pre-activation and reflex phases were differently affected: in SLR and MLR, SOL is assumed to contribute to the decline in force output with a decreasing load, and, complementary in PRE and LLR, GM seems to be of major importance for force generation.

show abstract

Section: For the First Time This Article Documents Human Locomotor Bmentioning

confidence: 99%

Bouncing on Mars and the Moon—the role of gravity on neuromuscular control: correlation of muscle activity and rate of force development

Ritzmann

Freyler

Krause

et al. 2016

Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

“…In addition to drop towers, which enable a very short r-µ g phase of a few seconds, there are different orbital and sub-orbital platforms to perform experiments in r-µ g : Parabolic flights are frequently offered and the easiest to participate in and therefore considered the platform of choice for researchers to gain access to r-µ g experiments. However, repeating r-µ g -phases during the flight are flanked by hypergravity phases and interrupted by 1 g -phases, making it difficult to identify the effects solely attributed to r-µ g [ 104 ]. In addition, airplane vibration is often transferred onto the experiment and represents a further mechanical stimulus for the cells.…”

Section: Breast Cancer Cells Exposed To Microgravitymentioning

confidence: 99%

Breast Cancer Cells in Microgravity: New Aspects for Cancer Research

Nassef

Melnik

Kopp

et al. 2020

IJMS

View full text Add to dashboard Cite

Breast cancer is the leading cause of cancer death in females. The incidence has risen dramatically during recent decades. Dismissed as an “unsolved problem of the last century”, breast cancer still represents a health burden with no effective solution identified so far. Microgravity (µg) research might be an unusual method to combat the disease, but cancer biologists decided to harness the power of µg as an exceptional method to increase efficacy and precision of future breast cancer therapies. Numerous studies have indicated that µg has a great impact on cancer cells; by influencing proliferation, survival, and migration, it shifts breast cancer cells toward a less aggressive phenotype. In addition, through the de novo generation of tumor spheroids, µg research provides a reliable in vitro 3D tumor model for preclinical cancer drug development and to study various processes of cancer progression. In summary, µg has become an important tool in understanding and influencing breast cancer biology.

show abstract

“…b. Separation and isolation environments (similar to studies conducted in Antarctica or research that people live in and operate in specific environments and chambers, such as those conducted by volunteers traveling to Mars) [17] c. Parabolic flight: although weightlessness will be executed only for some seconds [18].…”

Section: Types Of Simulation Of Space Travelmentioning

confidence: 99%

“…Parabolic flight is the only simulation model that the person feels real microgravity. The airplane might fly until 30 periods maximally in a flight [18].…”

Section: Types Of Simulation Of Space Travelmentioning

confidence: 99%

Vitamin D in Space

Khoshvaghti¹

2019

Fads and Facts About Vitamin D

View full text Add to dashboard Cite

Mankind has explored space since many years ago for distinct purposes. The space environment has its special features including microgravity (weightlessness), radiation, vacuum, and extreme temperature. It is fascinating to hear space traveling or even living on another planet, but it may cause dramatic changes in the human body. The skeleton has the primary role for the human body on the Earth and also in space. Osteoporosis is the principal feature in spaceflights occurring sooner or later. It will pose health risks. The aging of the population is the cause for osteoporosis to be more prevalent in the future. It seems that aging will happen sooner in space for human beings that are accustomed to living on the Earth. A complex of all reported changes that would occur in space, the picture of a closely resembling aged man emerges. Vitamin D can be synthesized and acts as a hormone. Its receptors are evident in more than 30 human tissues. Vitamin D has positive effects on the skeleton and other systems of the body in many regards. Multiple actions have been claimed for vitamin D (real or false), many aspects of which are not fully understood. The issue applies more about the vitamin and space, which has been tried to describe in this chapter.

show abstract

Parabolic flight as a spaceflight analog

Cited by 55 publications

References 60 publications

Bouncing on Mars and the Moon—the role of gravity on neuromuscular control: correlation of muscle activity and rate of force development

Bouncing on Mars and the Moon—the role of gravity on neuromuscular control: correlation of muscle activity and rate of force development

Breast Cancer Cells in Microgravity: New Aspects for Cancer Research

Vitamin D in Space

Contact Info

Product

Resources

About